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Early Detection Of Disease Using Electronic Health Records And Fisher's Wishart Discriminant Analysis, Sijia Yang, Jian Bian, Zeyi Sun, Licheng Wang, Haojin Zhu, Haoyi Xiong, Yu Li

Engineering Management and Systems Engineering Faculty Research & Creative Works

Linear Discriminant Analysis (LDA) is a simple and effective technique for pattern classification, while it is also widely-used for early detection of diseases using Electronic Health Records (EHR) data. However, the performance of LDA for EHR data classification is frequently affected by two main factors: ill-posed estimation of LDA parameters (e.g., covariance matrix), and "linear inseparability" of the EHR data for classification. To handle these two issues, in this paper, we propose a novel classifier FWDA -- Fisher's Wishart Discriminant Analysis, which is developed as a faster and robust nonlinear classifier. Specifically, FWDA first surrogates the distribution of "potential" inverse …