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Articles 1 - 30 of 91
Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Hierarchical Structure And Properties Of The Bone At Nano Level, Farah Hamandi, Tarun Goswami
Hierarchical Structure And Properties Of The Bone At Nano Level, Farah Hamandi, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Bone is a highly hierarchical complex structure that consists of organic and mineral components represented by collagen molecules (CM) and hydroxyapatite crystals (HAC), respectively. The nanostructure of bone can significantly affect its mechanical properties. There is a lack of understanding how collagen fibrils (CF) in different orientations may affect the mechanical properties of the bone. The objective of this study is to investigate the effect of interaction, orientation, and hydration on atomic models of the bone composed of collagen helix (CH) and HAC, using molecular dynamics simulations and therefrom bone-related disease origins. The results demonstrate that the mechanical properties of …
Residual Properties Of Silicone (Med-4719) Lead With Leads From Retrieved Devices, Anmar Salih, Tarun Goswami
Residual Properties Of Silicone (Med-4719) Lead With Leads From Retrieved Devices, Anmar Salih, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Leads are designed for in vivo applications, however, for a definite period of time. In-vivo environment affects the mechanical behavior of implantable devices, therefore, there is a need to evaluate the residual properties of implantable leads used with pacemakers, defibrillator and neuro-stimulators. Silicone (MED-4719) lead is widely used in cardiac implantable electronic devices made by different manufacturers. . We collected 150 devices (with or without leads) from Anatomical Gift Program of the Wright State University. The objective of this study was to investigate the residual properties of Silicone (MED-4719) lead with different in vivo exposure time and compare the properties …
Traumatic Brain Injury Biomarkers, Simulations And Kinetics, Celeste Hicks, Akshima Dhiman, Chauntel Barrymore, Tarun Goswami
Traumatic Brain Injury Biomarkers, Simulations And Kinetics, Celeste Hicks, Akshima Dhiman, Chauntel Barrymore, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This paper reviews the predictive capabilities of blood-based biomarkers to quantify traumatic brain injury (TBI). Biomarkers for concussive conditions also known as mild, to moderate and severe TBI identified along with post-traumatic stress disorder (PTSD) and chronic traumatic encephalopathy (CTE) that occur due to repeated blows to the head during one’s lifetime. Since the pathways of these biomarkers into the blood are not fully understood whether there is disruption in the blood–brain barrier (BBB) and the time it takes after injury for the expression of the biomarkers to be able to predict the injury effectively, there is a need to …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …
Safe Zones In Hip-Implant Designs To Resist Dislocation, Himanshu Bhatt, Tarun Goswami
Safe Zones In Hip-Implant Designs To Resist Dislocation, Himanshu Bhatt, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Major contributing parameters to hip implant dislocation include preoperative, intra-operative and post-operative factors. Implant geometry are design as well as non-design related. Femoral and acetabular component design features causing dislocation and/or resisting it are elucidated. Twelve implants were designed during this investigation were analyzed for dislocation resistance. A safe zone, establishes combinations of implant dimensions, was analyzed for all the 12 implants where implants were dislocation resistant. Head diameters between 26 mm to 32 mm, neck diameters closer to 14 mm, and neck angle between 25 to 35º were examined to be the safest ranges for hip implant designs.
Probabilistic Risk Assessment For Life Extension Of Turbine Engine Rotors, Jace A. Carter, Tarun Goswami
Probabilistic Risk Assessment For Life Extension Of Turbine Engine Rotors, Jace A. Carter, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Maintaining the component service life beyond its historical limits requires the ability to accurately quantify component reliability and address the uncertainties in material responses. A probabilistic method for predicting the total fatigue life was developed and applied to determine the probability of failure of a Ti-6Al-4V turbine disk component. The total fatigue life incorporates a dual mechanism approach including the crack initiation life and propagation life while simultaneously determining the associated initial flaw sizes. A microstructure-based model was employed to address the uncertainties in material response and relate the crack initiation life with crack size. The propagation life was characterized …
Validation Of Experimental And Finite Element Biomechanical Evaluation Of Human Cadaveric Mandibles, Shirish M. Ingawale, Deepak G. Krishnan, Tarun Goswami
Validation Of Experimental And Finite Element Biomechanical Evaluation Of Human Cadaveric Mandibles, Shirish M. Ingawale, Deepak G. Krishnan, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Background: Biomechanical analysis of human mandible is important not only to understand mechanical behavior and structural properties, but also to diagnose and develop treatment options for mandibular disorders. Therefore, the objective of this research was to generate analytical and experimental data on mandibles, construct custom 3D models, and compare the analytically derived maximum strains with strain gage data in five areas of interest for each mandible. Methods: We investigated the surface strains in the cadaveric human mandibles under different configurations of cyclic compressive loads in an experimental setting and compared these experimental strain data with results derived from computational finite …
Characterization Of In Vivo Damage On Retrieved Total Shoulder Glenoid Liners, Eric Cheatwood, Gerard Simon, Lynn Crosby, Tarun Goswami
Characterization Of In Vivo Damage On Retrieved Total Shoulder Glenoid Liners, Eric Cheatwood, Gerard Simon, Lynn Crosby, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
An attempt was made to retrieve glenoid liners from revision surgery to undertake a retrospective study to measure the resulting in vivo damage. Since the glenoid liners are circumferential, the curvature changes at every point in the component, an “assisting arm” was designed to hold the liner firmly, thus allowing accurate microscopic measurements. We characterized the damage in terms of pitting, embedded debris, complete fracture, abrasion, deformation, delamination, burnishing, grooving, and scratching that took place mutually exclusively. This study of 26 liners showed embedded debris was the most underrated damage mode found on the liners, followed by pitting and abrasion, …
Etiology Of Breast Development And Asymmetry, Elisabeth N. Adkins, Shaina Anderson, Trevor Mckoy, Nakachi Maduka, Tarun Goswami
Etiology Of Breast Development And Asymmetry, Elisabeth N. Adkins, Shaina Anderson, Trevor Mckoy, Nakachi Maduka, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Etiology of breast development and asymmetry is a fascinating research topic physiologically as well as pathophysiology from a certain condition. The shape, contour, and size of the breast are unique to each female. These factors are influenced by genetics, weight, exercise, menstruation cycles, pregnancy, menopause status, and age. An attempt was made to research the breast development at fetal development and transitioning into adulthood and menopause. Additionally, we compare breast development in males to the developments in females. Although breast asymmetry is experienced by all women, it ranges from grossly undetectable to the need for surgical intervention. It is thought …
Application Of Probabilistic Methods To Turbine Engine Disk Life Prediction And Risk Assessment, Paul Copp, Ashley Whitney-Rawls, Jace Carter, Tarun Goswami
Application Of Probabilistic Methods To Turbine Engine Disk Life Prediction And Risk Assessment, Paul Copp, Ashley Whitney-Rawls, Jace Carter, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Turbine engine disk life prediction and understanding the associated risk remains a significant challenge for today’s designer. Despite advances made in materials testing and characterization, as well as, the application of damage tolerance and linear elastic fracture mechanics modeling, there remains a void in properly assessing loading, geometry, and material design property variability. Add to this the application of advanced hybrid and composite material systems and the need to accurately deal with material variability is even greater. There still remain incidents of failure of critical components which were not properly accounted for by the existing analytical methods, testing, and inspections …
Effectiveness Of Mesoporous Bioglass In Drug Delivery, Sheila Galbreath, Bailey Krueger, Taylor Frazier, Tarun Goswami
Effectiveness Of Mesoporous Bioglass In Drug Delivery, Sheila Galbreath, Bailey Krueger, Taylor Frazier, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Since the invention of bioactive glass 50 years ago, it has become a versatile material used in healthcare in a variety of applications and compositions. Bioactive glass has shown superior capabilities of drug delivery compared to traditional carriers. For example, time-released medications are less likely to reach toxic levels, while delivering a specific, therapeutic dose to a localized area. The objective of this paper is to investigate the properties and effectiveness of mesoporous bioglass (MBG) as a drug delivery carrier. A literature review of various polymer coated 45S5 Bioglass® loaded with vancomycin was analyzed to determine their drug release …
Design And Finite Element Analysis Of Patient-Specific Total Temporomandibular Joint Implants, Shirish M. Ingawale, Tarun Goswami
Design And Finite Element Analysis Of Patient-Specific Total Temporomandibular Joint Implants, Shirish M. Ingawale, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
In this manuscript, we discuss our approach to developing novel patient-specific total TMJ prostheses. Our unique patient-fitted designs based on medical images of the patient’s TMJ offer accurate anatomical fit, and better fixation to host bone. Special features of the prostheses have potential to offer improved osseo-integration and durability of the devices. The design process is based on surgeon’s requirements, feedback, and pre-surgical planning to ensure anatomically accurate and clinically viable device design. We use the validated methodology of FE modeling and analysis to evaluate the device design by investigating stress and strain profiles under functional/normal and para-functional/worst-case TMJ loading …
Degradation Mechanisms Of Zinc-Air Batteries Used In Hearing Aid, Kelly Hunt, Mallorty Bates, Gerard Klint Simon, Tarun Goswami
Degradation Mechanisms Of Zinc-Air Batteries Used In Hearing Aid, Kelly Hunt, Mallorty Bates, Gerard Klint Simon, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Hearing aid devices are powered by the oxidation of zinc that occurs within zinc-air batteries. Zinc-air batteries have an average discharge time of 7 days. Therefore, hearing-aid devices need frequent battery replacement. In this paper, degradation mechanisms of zinc-air batteries investigated where a competition mechanism between zinc passivation and dendritic formation dictates the battery life. This research included exposure time from none to 9 days and to document dendritic growth with time. Scanning electron microscope images were taken to quantify the damage growth as well energy dispersive X-ray tests were conducted to comment on the composition changes. The results confirmed …
Comparison Of Aero Engine Component Lifing Methods, Ashley Whitney-Rawls, Paul Copp, Jace Carter, Tarun Goswami
Comparison Of Aero Engine Component Lifing Methods, Ashley Whitney-Rawls, Paul Copp, Jace Carter, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Failure of critical engine components such as compressor, fan, and turbine disks during flight can cause the loss of the engine, aircraft, or even life. To reduce the risk of this failure during flight, different methodologies and tools have been developed to determine the safe operating life of these critical disk components. The two most widely used lifing methods, safe-life and damage tolerance, are inherently conservative, retiring all components when a predetermined operating limit is reached. Both methods retire components with theoretical useful life remaining. Additional lifing methods can be used to reduce this conservatism and extend the life of …
Relationship Between Applied Load And Clearance In Suture Knots, Amena S. Shermadou, Steven R. Lindheim, Jerome L. Yaklic, Tarun Goswami
Relationship Between Applied Load And Clearance In Suture Knots, Amena S. Shermadou, Steven R. Lindheim, Jerome L. Yaklic, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Ethicon Coated Vicryl absorbable sutures of different diameters were studied in order to determine if a relationship exists between the load and measured clearance. A prototype was designed to simulate knot location. Tensile tests were conducted on the suture knots followed by clearance measurements after each load level was applied. From the results it was concluded that the measured clearance was directly proportional to the amount of load applied to the suture knot. Also, based on the diameter of the suture, the smaller the diameter, the lower was the total displacement of the knot or the clearance.
Gender-Specific Anterior Cruciate Ligament – Gait Forces, Bharadwaj Cheruvu, Amy Neidhard-Doll, Tarun Goswami
Gender-Specific Anterior Cruciate Ligament – Gait Forces, Bharadwaj Cheruvu, Amy Neidhard-Doll, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The purpose of this study was to investigate gender-based differences in gait biomechanics and to evaluate those effects on forces generated on the ACL during walking. Estimation of gender-specific ACL forces in the frontal plane can provide a better understanding of the biomechanical patterns underlying higher female injury risk. The present study used a sample from the Fels Longitudinal Study to test the hypothesis that there are significant gender-differences in frontal plane ACL loading during walking. A cross-sectional sample of 178 participants, including 79 males and 99 females was used to evaluate differences in gait kinetics. Females walked at higher …
Simulation Of Gene Regulatory Elements For Biosensing, Mallory Bates, Svetlana Harbough, Tarun Goswami
Simulation Of Gene Regulatory Elements For Biosensing, Mallory Bates, Svetlana Harbough, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Gene regulatory studies are of significant importance in many scenarios such as mental illness. 21% of U.S adults experience mental illnesses including 1 in 4 active-duty military personnel. Mental health can be identified in the body by different biomarkers. These biomarkers potentially controlled by riboswitches, which are located in mRNA and switch “ON” or “OFF” depending on the concentration of a biomarker. In this research, a known riboswitch reengineered and its response in the presence of a biomarker investigated. We changed computationally PreQ1, a known riboswitch that has the smallest aptamer, and then experimentally tested against biomarkers, dehydroepiandrosterone-sulfate …
In-Vivo Damage Development In Vena Cava Filter: Study Of A Retrieved Device, Anne Marie Lutz, Tarun Goswami
In-Vivo Damage Development In Vena Cava Filter: Study Of A Retrieved Device, Anne Marie Lutz, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This article was prepared from a project assigned in a graduate class, BME 7371, Failure Assessment of Medical Devices, taught at Wright State University by the senior author. The device was donated for the study which was successfully retrieved after 93 days in-vivo. Even-though the mechanical integrity of the device held in-tact, the microscopic observations revealed that the damage via corrosion and scratching took place on the surface of the device. The image reconstructed in 3D using image-J software to determine device roughness and depth-of-pits. Results presented in this paper show that damage starts developing in these devices after the …
Mechanical Properties Of Nanoparticles In The Drug Delivery Kinetics, Kaivon Assani, Amy Neidhard-Doll, Tarun Goswami
Mechanical Properties Of Nanoparticles In The Drug Delivery Kinetics, Kaivon Assani, Amy Neidhard-Doll, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the drug of choice and delivers it to the target via a targeting molecules (ex. antigen) located on the nanoparticle surface. Nanoparticles can even be targeted to deeply penetrating tissue and can be modeled to deliver drugs through the blood brain barrier. These advancements are providing better disease targeting such as to cancer and Alzheimer’s. Various polymers can be manufactured into nanoparticles. The polymers examined in this paper are polycaprolactone (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(glycolic acid) (PGA). The purpose of this …
Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami
Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug delivery systems for targeted delivery. Nanoparticulate carriers that are used for drug delivery systems include polymers, micelles, dendrimers, liposomes, ceramics, metals, and various forms of biological materials. The properties of these nanoparticulate carriers are very advantageous for targeted drug delivery and result in efficient drug accumulation at the targeted area of interest, reduced drug toxicity, reduced systemic side effects, and more efficient use of the drug overall. Nanoparticlulate …
Biomechanical Evaluation Of Recurrent Dissociation Of Modular Humeral Prostheses, Daniel B. Luckenbill, Mike F. Iossi, Alyssa M. George Whitney, Danielle Miller, Lynn A. Crosby, Tarun Goswami
Biomechanical Evaluation Of Recurrent Dissociation Of Modular Humeral Prostheses, Daniel B. Luckenbill, Mike F. Iossi, Alyssa M. George Whitney, Danielle Miller, Lynn A. Crosby, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The purpose of the study was to evaluate the force and torque required to dissociate a humeral head from the unimplanted modular total shoulder replacement system from different manufacturers and to determine if load and torque to dissociation are reduced in the presence of bodily fluids. Impingement, taper contamination, lack of compressive forces, and interference of taper fixation by the proximal humerus have all been reported as possible causes for dissociation. Experimental values determined in this research were compared with literature estimates of dissociation force of the humeral head under various conditions to gain more understanding of the causes of …
Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami
Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The most critical component of the TDDS is the adhesive, which is responsible for the safety, efficacy and quality of the patch. For drug delivery to successfully occur, the patch must adhere to the surface of the contact area. If a patch has inadequate adhesion, it is likely to fall off before the entire delivery period has been satisfied, leading to risks for the patient and others who may encounter the patch. Despite the critical concerns associated with the adhesive properties of the patches, the adhesion quality and failure mechanisms have not been fully studied. If certain molecules encounter the …
Retrospective Evaluation And Framework Development Of Bone Anisotropic Material Behavior Compared With Elastic, Elastic-Plastic, And Hyper-Elastic Properties, Farah Hamandi, James T. Tsatalis, Tarun Goswami
Retrospective Evaluation And Framework Development Of Bone Anisotropic Material Behavior Compared With Elastic, Elastic-Plastic, And Hyper-Elastic Properties, Farah Hamandi, James T. Tsatalis, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The main motivation for studying damage in bone tissue is to better understand how damage develops in the bone tissue and how it progresses. Such knowledge may help in the surgical aspects of joint replacement, fracture fixation or establishing the fracture tolerance of bones to prevent injury. Currently, there are no standards that create a realistic bone model with anisotropic material properties, although several protocols have been suggested. This study seeks to retrospectively evaluate the damage of bone tissue with respect to patient demography including age, gender, race, body mass index (BMI), height, and weight, and their role in causing …
Cyclic Damage Accumulation In The Femoral Constructs Made With Cephalomedullary Nails, Farah Hamandi, Alyssa Whitney, Mark H. Stouffer, Michael J. Prayson, Jorn Rittweger, Tarun Goswami
Cyclic Damage Accumulation In The Femoral Constructs Made With Cephalomedullary Nails, Farah Hamandi, Alyssa Whitney, Mark H. Stouffer, Michael J. Prayson, Jorn Rittweger, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Background: The purpose of this study was to evaluate the risk of peri-prosthetic fracture of constructs made with cephalomedullary (CM) long and short nails. The nails were made with titanium alloy (Ti-6Al-4V) and stainless steel (SS 316L). Methods: Biomechanical evaluation of CM nail constructs was carried out with regard to post-primary healing to determine the risk of peri-implant/peri-prosthetic fractures. Therefore, this research comprised of, non-fractured, twenty-eight pairs of cadaveric femora that were randomized and implanted with four types of fixation CM nails resulting in four groups. These constructs were cyclically tested in bi-axial mode for up to 30,000 cycles. All …
Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami
Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This paper examines the mechanics of the tibiotalocalcaneal construct made with a PHILOS plating system. A failed device consisting of the LCP plate and cortical, locking, and cannulated screws was used to perform the analysis. Visual, microstructure, and fractographic examinations were carried out to characterize the fracture surface topology. These examinations revealed the presence of surface scratching, inclusions, discoloration, corrosion pits, beach marks, and cleavage and striations on the fracture surface. Further examination of the material crystallography and texture revealed an interaction of S, Ni, and Mo-based inclusions that may have raised pitting susceptibility of the device made with Stainless …
Investigation Of Retrieved Cardiac Devices, Anmar Salih, Iosif Papadakis Ktistakis, Spyridon Manganas, Abdul Wase, Tarun Goswami
Investigation Of Retrieved Cardiac Devices, Anmar Salih, Iosif Papadakis Ktistakis, Spyridon Manganas, Abdul Wase, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Damage assessment of lead and pulse generator with various exposure times is important in the development of cardiac devices. Approximately, 92.1 million patients in the US suffer from cardiovascular diseases with an estimated healthcare cost of over $300 billion and at least one million with implantable cardiac devices. These devices are complex and composed on multiple levels and present challenges while assessing the damage. However, the study on the analysis of cardiac devices may lend insight into common damage patterns and improve future cardiac devices design. The objective of this work is to perform a thorough in vivo damage assessment …
Investigation Of A Neuro-Stimulator Retrieved Posthumously, Megan Markl, Rodney J. Gutherie, Tarun Goswami
Investigation Of A Neuro-Stimulator Retrieved Posthumously, Megan Markl, Rodney J. Gutherie, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
A neurostimulator was investigated in this paper posthumously. Device was presented to our anatomical gift program. Investigation was multi-fold and contained visual inspection, using an optical microscope, and mechanical and electrical testing of leads and its insulator. It was concluded that the device could have been damaged during implantation, in vivo, during removal, and/or during transportation to author’s laboratories. The damage observed on the lead insulation is similar to that which can occur due to anchoring of the lead and hardening due to oxidation. Insulation stiffness was determined to be 1/10 of new insulator. The results reported here on the …
Simulation Of Skull Fracture Due To Falls, Anthony Vicini, Tarun Goswami
Simulation Of Skull Fracture Due To Falls, Anthony Vicini, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This study presents novel predictive equations for von Mises stress values of bones in the frontal and lateral regions of the skull. The equations were developed based on results of a finite element model developed during this research. The model was validated for frontal and lateral loading conditions with input values mimetic to fall scenarios. Using neural network processing of the information derived from the model achieved R2 values of 0.9990 for both the stress and deflection. Based on the outcome of the fall victims, a threshold von Mises stress of 40.9 to 46.6 MPa was found to indicate skull …
Deep Brain Stimulation: Prediction Model For Volume Of Tissue Stimulated, Melissa Jones, Tarun Goswami
Deep Brain Stimulation: Prediction Model For Volume Of Tissue Stimulated, Melissa Jones, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
An attempt has been made to understand deep brain stimulation in humans via marketable devices that are approved by the US Food and Drug Administration. The electrode characteristics were presented to influence the volume of tissue stimulated. Experimental data were digitized and VTS data were presented a function of electrode diameter, aspect ratio, applied current, pulse duration, voltage and frequency. Amongst other trends voltage and VTS were found to exhibit a three-stage relation, where Stage II characteristics were represented by a linear equation. It is in this stage, the VTS was found to be stable and where the most effective …