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Wayne State University Dissertations

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Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering

An Agile Quality Management System For Laboratory Developed Tests, Rita D'Angelo Jan 2018

An Agile Quality Management System For Laboratory Developed Tests, Rita D'Angelo

Wayne State University Dissertations

ABSTRACT

AN AGILE QUALITY MANAGEMENT SYSTEM FOR LABORATORY DEVELOPED TESTS

By

RITA D’ANGELO

MAY 2017

Advisor: Dr. Ratna Babu Chinnan

Major: Industrial & Systems Engineering

Degree: Doctor of Philosophy Statement of the Problem: We explore the 2014 draft guidance by the FDA entitled Framework for Regulatory Oversight of Laboratory Developed Tests (LDT) extended from the medical device industry and discuss how these requirements may be applicable to laboratory medicine. We introduce terms, definitions and provide a call for action for leaders to prepare for the potential adherence to regulatory requirements and explore if compliance was achievable in a laboratory environment ...


Enhancing Set-Based Design To Engineer Resilience For Long-Lived Systems, Gregory Hartman Jan 2018

Enhancing Set-Based Design To Engineer Resilience For Long-Lived Systems, Gregory Hartman

Wayne State University Dissertations

At the heart of Set-Based Design is the concept that down-select decisions are deferred until sufficient information is available to make a decision, i.e., a set of possible solutions is maintained. Due to the extended service lives of many of our current and future systems, the horizon for accurately predicting the system’s requirement is shorter than the service life, so the needed information to down-select to a single optimized solution is unavailable at the time of fielding. Set-Based Design can, however, be extended to explicitly carry a set of possible solutions past the point of the initial fielding ...


Influential Factors In Consumer's Adoption Of Innovative Products, Mahdokht Kalantari Jan 2018

Influential Factors In Consumer's Adoption Of Innovative Products, Mahdokht Kalantari

Wayne State University Dissertations

This dissertation addresses the challenges involved with the process of diffusion of innovations in the contexts of innovative educational materials and technological innovations.

Chapters 2 and 3 discuss building and using Online Brand Communities (OBCs) to disseminate innovative math educational materials. OBCs are known to be important platforms where consumers can communicate with the brand as well as other consumers. Through the effective use of these platforms, brands could accelerate the process of diffusion of their innovations. However, OBCs will not survive if consumers do not get engaged and participate in these communities. The purpose of this section of the ...


A Data-Driven And Mixed Methods Analysis Of Automotive Retail Operations Management, Mark Allen Colosimo Jan 2018

A Data-Driven And Mixed Methods Analysis Of Automotive Retail Operations Management, Mark Allen Colosimo

Wayne State University Dissertations

The importance of effective retail operations management has never been more significant. Our research aims to expand the understanding for efficiency and dynamics of franchise outlets within retail networks with a focus on sales performance and profitability. The focus and contribution is the development of an actionable data analytics driven process by which automotive dealerships (retail outlets) can be analyzed to identify areas of opportunity for improvement. In general, automotive dealerships aim to sell product to make a profit, the manufacturer of the product/brand desires to sell vehicles to make a profit, and the customer desires to find a ...


Proactive Coordination In Healthcare Service Systems Through Near Real-Time Analytics, Seung Yup Lee Jan 2018

Proactive Coordination In Healthcare Service Systems Through Near Real-Time Analytics, Seung Yup Lee

Wayne State University Dissertations

The United States (U.S.) healthcare system is the most expensive in the world. To improve the quality and safety of care, health information technology (HIT) is broadly adopted in hospitals. While EHR systems form a critical data backbone for the facility, we need improved 'work-flow' coordination tools and platforms that can enhance real-time situational awareness and facilitate effective management of resources for enhanced and efficient care. Especially, these IT systems are mostly applied for reactive management of care services and are lacking when they come to improving the real-time "operational intelligence" of service networks that promote efficiency and quality ...


Reliability Analysis By Considering Steel Physical Properties, Wujun Si Jan 2018

Reliability Analysis By Considering Steel Physical Properties, Wujun Si

Wayne State University Dissertations

Most customers today are pursuing engineering materials (e.g., steel) that not only can achieve their expected functions but also are highly reliable. As a result, reliability analysis of materials has been receiving increasing attention over the past few decades. Most existing studies in the reliability engineering field focus on developing model-based and data-driven approaches to analyze material reliability based on material failure data such as lifetime data and degradation data, without considering effects of material physical properties. Ignoring such effects may result in a biased estimation of material reliability, which in turn could incur higher operation or maintenance costs ...


Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad Jan 2018

Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad

Wayne State University Dissertations

Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm ...


Developing Innovation Capability In A Mass Production Organization, Mark Douglas Dolsen Jan 2017

Developing Innovation Capability In A Mass Production Organization, Mark Douglas Dolsen

Wayne State University Dissertations

ABSTRACT

DEVELOPING INNOVATION CAPABILITY IN A MASS PRODUCTION ORGANIZATION

by

MARK DOLSEN

May 2017

Advisor: Dr. Ratna Babu Chinnam

Major: Industrial Engineering

Degree: Doctor of Philosophy

Auto parts manufacturing is a key element of the North American automotive supply chain, and a significant component of the economy of Ontario, Canada. Employment in this sector declined 40% from 2003 to 2010 as the industry experienced a recession, and many firms relocated to lower wage jurisdictions as the Canadian currency strengthened against the US dollar. Experts contend that the solution for the industry lies in innovation; however, recommendations found in the current ...


Essays On Stochastic Programming In Service Operations Management, Sina Faridimehr Jan 2017

Essays On Stochastic Programming In Service Operations Management, Sina Faridimehr

Wayne State University Dissertations

Deterministic mathematical modeling is a branch of optimization that deals with decision making in real-world problems. While deterministic models assume that data and parameters are known, these numbers are often unknown in the real world applications.The presence of uncertainty in decision making can make the optimal solution of a deterministic model infeasible or sub-optimal.

On the other hand, stochastic programming approach assumes that parameters and coefficients are unknown and only their probability distribution can be estimated. Although stochastic programming could include uncertainties in objective function and/or constraints, we only study problems that the goal of stochastic programming ...


Product Development Resilience Through Set-Based Design, Stephen H. Rapp Jan 2017

Product Development Resilience Through Set-Based Design, Stephen H. Rapp

Wayne State University Dissertations

Often during a system Product Development program external factors or requirements change, forcing system design change. This uncertainty adversely affects program outcome, adding to development time and cost, production cost, and compromise to system performance. We present a development approach that minimizes the impacts, by considering the possibility of changes in the external factors and the implications of mid-course design changes. The approach considers the set of alternative designs and the burdens of a mid-course change from one design to another in determining the relative value of a specific design. The approach considers and plans parallel development of alternative designs ...


Human-Machine Interface Development For Modifying Driver Lane Change Behavior In Manual, Automated, And Shared Control Automated Driving, Walter Joseph Talamonti Jan 2017

Human-Machine Interface Development For Modifying Driver Lane Change Behavior In Manual, Automated, And Shared Control Automated Driving, Walter Joseph Talamonti

Wayne State University Dissertations

Rear-end crashes are common on U.S. roads. Driver assistance and automated driving technologies can reduce rear-end crashes (among other crash types as well). Braking is assumed for forward collision warning (FCW) and automatic emergency braking (AEB) systems. Braking is also used for adaptive cruise control (ACC) and in automated driving systems more generally. However, steering may be advised in an emergency if the adjacent lane is clear and braking is unlikely to avoid a collision. Steering around an obstacle when feasible also eliminates the risk of becoming the new forward collision hazard. Driver assist technology like emergency steer assist ...


Evolving Clustering Algorithms And Their Application For Condition Monitoring, Diagnostics, & Prognostics, Fling Finn Tseng Jan 2017

Evolving Clustering Algorithms And Their Application For Condition Monitoring, Diagnostics, & Prognostics, Fling Finn Tseng

Wayne State University Dissertations

Applications of Condition-Based Maintenance (CBM) technology requires effective yet generic data driven methods capable of carrying out diagnostics and prognostics tasks without detailed domain knowledge and human intervention. Improved system availability, operational safety, and enhanced logistics and supply chain performance could be achieved, with the widespread deployment of CBM, at a lower cost level. This dissertation focuses on the development of a Mutual Information based Recursive Gustafson-Kessel-Like (MIRGKL) clustering algorithm which operates recursively to identify underlying model structure and parameters from stream type data. Inspired by the Evolving Gustafson-Kessel-like Clustering (eGKL) algorithm, we applied the notion of mutual information to ...


Knowledge Reuse Through Electronic Knowledge Repositories: An Empirical Study And Ontological Improvement Effort For The Manufacturing Industry, Peter Panha Chhim Jan 2016

Knowledge Reuse Through Electronic Knowledge Repositories: An Empirical Study And Ontological Improvement Effort For The Manufacturing Industry, Peter Panha Chhim

Wayne State University Dissertations

Knowledge management adoption is growing, and will continue to grow in no small part because of its recent inclusion into the ISO 9001 quality standard. As organizations look towards ways in which to manage their knowledge, the codification of explicit knowledge through Knowledge Management Systems (KMS) and Electronic Knowledge Repositories (EKRs) will undoubtedly gain more interest.

An EKR is a form of KMS that emphasizes the codification and storage of organizational expertise for the purposes of Knowledge Reuse (KRU). Unfortunately, the factors surrounding KRU are not well understood. While previous studies have viewed EKR usage from a narrow perspective, a ...


Computational Modeling Approaches For Task Analysis In Robotic-Assisted Surgery, Mahtab Jahanbani Fard Jan 2016

Computational Modeling Approaches For Task Analysis In Robotic-Assisted Surgery, Mahtab Jahanbani Fard

Wayne State University Dissertations

Surgery is continuously subject to technological innovations including the introduction of robotic surgical devices. The ultimate goal is to program the surgical robot to perform certain difficult or complex surgical tasks in an autonomous manner. The feasibility of current robotic surgery systems to record quantitative motion and video data motivates developing descriptive mathematical models to recognize, classify and analyze surgical tasks. Recent advances in machine learning research for uncovering concealed patterns in huge data sets, like kinematic and video data, offer a possibility to better understand surgical procedures from a system point of view. This dissertation focuses on bridging the ...


Technology Decisions In New Product Development, Amir Sanayei Jan 2016

Technology Decisions In New Product Development, Amir Sanayei

Wayne State University Dissertations

Selecting the right technology is one of the most important and challenging decisions in new product development (NPD) process that can greatly affect all downstream design activities which have a great impact on product success in the market place. Although new technologies may bring more competitive advantage by offering higher performance to price, they also make the NPD process more risky and challenging. We model the technology selection problem of a firm that is defining its new product in the presence of the technology uncertainty. At each review stage, firm has the options: select and commit to any technology alternatives ...


A Prediction Modeling Framework For Noisy Welding Quality Data, Junheung Park Jan 2015

A Prediction Modeling Framework For Noisy Welding Quality Data, Junheung Park

Wayne State University Dissertations

Numerous and various research projects have been conducted to utilize historical manufacturing process data in product design. These manufacturing process data often contain data inconsistencies, and it causes challenges in extracting useful information from the data. In resistance spot welding (RSW), data inconsistency is a well-known issue. In general, such inconsistent data are treated as noise data and removed from the original dataset before conducting analyses or constructing prediction models. This may not be desirable for every design and manufacturing applications since every data can contain important information to further explain the process. In this research, we propose a prediction ...


Lean Thinking For Lead-Time Reduction And Efficient Knowledge Creation In Product Development, Satish Kumar Tyagi Jan 2015

Lean Thinking For Lead-Time Reduction And Efficient Knowledge Creation In Product Development, Satish Kumar Tyagi

Wayne State University Dissertations

There are many distinct differences between manufacturing process and Product Development (PD) process, so lean tools have to be customized to deliver results in the later domain. The main focus of this dissertation is to extend them to manage and improve the PD process in order to develop the product faster while improving or at least maintaining the level of performance and quality. For aforesaid purpose, value stream mapping (VSM) method is used to explore the wastes, inefficiencies, non-valued added steps in a single, definable process out of complete PD process. Besides numerous intangible benefits, VSM framework will help the ...


Reliability Analysis And Optimal Maintenance Planning For Repairable Multi-Component Systems Subject To Dependent Competing Risks, Nailong Zhang Jan 2015

Reliability Analysis And Optimal Maintenance Planning For Repairable Multi-Component Systems Subject To Dependent Competing Risks, Nailong Zhang

Wayne State University Dissertations

Modern engineering systems generally consist of multiple components that interact in a complex manner. Reliability analysis of multi-component repairable systems plays a critical role for system safety and cost reduction. Establishing reliability models and scheduling optimal maintenance plans for multi-component repairable systems, however, is still a big challenge when considering the dependency of component failures. Existing models commonly make prior assumptions, without statistical verification, as to whether different component failures are independent or not. In this dissertation, data-driven systematic methodologies to characterize component failure dependency of complex systems are proposed. In CHAPTER 2, a parametric reliability model is proposed to ...


A Framework To Improve A Nation's Competitiveness Through Quality Awards And Performance Improvement Tools, Amr Alamri Jan 2015

A Framework To Improve A Nation's Competitiveness Through Quality Awards And Performance Improvement Tools, Amr Alamri

Wayne State University Dissertations

Each country, represented by its government, aims to serve its citizens better. This is achieved by better utilization of resources and higher productivity. The ability to do so will lead to a competitive nation. Recently, countries were able to compare themselves in terms of competitiveness using international indexes and references. These references gave countries a benchmark to know where they exist compared to other nations. They help governments to understand their strengths and weaknesses within the competitiveness components. However, nations differ in the actions which are to be taken in order to improve their competitiveness. Governments establish and regulate many ...


Formal Design Concept And Participant Behavior Analysis For Crowdsourcing Design, Jihoon Kim Jan 2015

Formal Design Concept And Participant Behavior Analysis For Crowdsourcing Design, Jihoon Kim

Wayne State University Dissertations

Crowdsourcing has emerged as a new design resource for conceptual design process and multiple crowdsourcing services provide an opportunity for design idea collection and concept generation by crowds. However, few formal methods are available to extract and evaluate design concepts from the activities of the design crowd. Scarcity of information and non-guaranteed quality of contributions are often challenges to be tackled. To overcome the challenges, the research aims to answer how a system systematically extracts and represents the explicit or implicit hidden design concepts from crowdsourcing design activities and how crowdsourcing design activities of participants are captured as design information ...


Modeling And Optimization Of Non-Profit Hospital Call Centers With Service Blending, Yanli Zhao Jan 2015

Modeling And Optimization Of Non-Profit Hospital Call Centers With Service Blending, Yanli Zhao

Wayne State University Dissertations

This dissertation focuses on the operations problems in non-profit hospital call centers with inbound and outbound calls service blending.

First, the routing policy for inbound and outbound calls is considered. The objective is to improve the system utilization under constraints of service quality and operators' quantity. A collection of practical staffing assignment methods, separating and mixing staffing policy are evaluated. Erlang C queuing model is used to decide the minimum number of operators required by inbound calls. Theoretical analysis and numerical experiments illustrate that through dynamically assigning the inbound and outbound calls to operators under optimal threshold policy, mixing staffing ...


Frontiers In Operations Research For Overcoming Barriers To Vehicle Electrification, Mahyar Movahed Nejad Jan 2015

Frontiers In Operations Research For Overcoming Barriers To Vehicle Electrification, Mahyar Movahed Nejad

Wayne State University Dissertations

Electric vehicles (EVs) hold many promises including diversification of the transportation energy feedstock and reduction of greenhouse gas and other emissions. However, achieving large-scale adoption of EVs presents a number of challenges resulting from a current lack of supporting infrastructure and difficulties in overcoming technological barriers. This dissertation addresses some of these challenges by contributing to the advancement of theories in the areas of network optimization and mechanism design.

To increase the electric driving range of plug-in hybrid electric vehicles (PHEVs), we propose a powertrain energy management control system that exploits energy efficiency dif- ferences of the electric machine and ...


Improving Emergency Department Patient Flow Through Near Real-Time Analytics, Shanshan Qiu Jan 2014

Improving Emergency Department Patient Flow Through Near Real-Time Analytics, Shanshan Qiu

Wayne State University Dissertations

ABSTRACT

IMPROVING EMERGENCY DEPARTMENT PATIENT FLOW THROUGH NEAR REAL-TIME ANALYTICS

This dissertation research investigates opportunities for developing effective decision support models that exploit near real-time (NRT) information to enhance the "operational intelligence" within hospital Emergency Departments (ED). Approaching from a systems engineering perspective, the study proposes a novel decision support framework for streamlining ED patient flow that employs machine learning, statistical and operations research methods to facilitate its operationalization.

ED crowding has become the subject of significant public and academic attention, and it is known to cause a number of adverse outcomes to the patients, ED staff as well as ...


An Analytics Approach To Designing Patient Centered Medical Home, Saeede Ajorlou Jan 2014

An Analytics Approach To Designing Patient Centered Medical Home, Saeede Ajorlou

Wayne State University Dissertations

Recently the patient centered medical home (PCMH) model has become a popular team based approach focused on delivering more streamlined care to patients. In current practices of medical homes, a clinical based prediction frame is recommended because it can help match the portfolio capacity of PCMH teams with the actual load generated by a set of patients. Without such balances in clinical supply and demand, issues such as excessive under and over utilization of physicians, long waiting time for receiving the appropriate treatment, and non continuity of care will eliminate many advantages of the medical home strategy. In this research ...


An Analytics Approach To Reducing Hospital Readmission, Issac Shams Jan 2014

An Analytics Approach To Reducing Hospital Readmission, Issac Shams

Wayne State University Dissertations

One of the significant sources of waste in the Unites States health care systems is preventable hospital readmission. About 2.3 million Medicare fee-for-service beneficiaries are re-hospitalized within 30 days after discharge which incurs an annual cost of $17 billion. However, it is reported by the Medicare Payment Advisory Commission that about 75% of such readmissions can and should be avoided because they are the results of factors such as poor planning for follow up care transitions, inadequate communication of discharge instructions, and failure to reconcile and coordinate medications. Hence, reducing unnecessary rehospitalization through care transition and systems engineering principles ...


Global E-Mentoring: Overcoming Virtual Distance For An Effective Mentoring Relationship, Nancy Philippart Jan 2014

Global E-Mentoring: Overcoming Virtual Distance For An Effective Mentoring Relationship, Nancy Philippart

Wayne State University Dissertations

Mentoring can enhance an employee's career development and advancement but traditional face-to-face mentoring has become less relevant because of globalization, increased employee mobility and technology-enabled work. A new mentoring model enabled by technology has emerged to meet the needs of today's complex, fast changing global workplace. Although e-mentoring has several advantages over traditional mentoring, the absence of regular face-to-face interactions requires different strategies to develop an effective mentoring relationship. Moreover, additional complexities arise when this virtual mentoring is global.

This research utilizes the construct of virtual distance, the "psychological separation" that has been found to impact performance outcomes ...


Demand Modeling And Capacity Planning For Innovative Short Life-Cycle Products, Saman Alaniazar Jan 2013

Demand Modeling And Capacity Planning For Innovative Short Life-Cycle Products, Saman Alaniazar

Wayne State University Dissertations

This dissertation focuses on demand modeling and capacity planning for innovative short life-cycle products. We first developed a new model in the class of stochastic Bass formulations that addresses the shortcomings of models from the extant literature. The proposed model considers the common fact that the market potential of a product is not fixed and might change during a life-cycle due to exogenous (e.g., economic- or competitors-related) or endogenous (e.g., quality-related) factors. Allowing this parameter (market potential in the Bass model) to follow a geometric random walk, we have showed that the future demand of a product in ...


Exact And Representative Algorithms For Multi Objective Optimization, Ozgu Turgut Jan 2013

Exact And Representative Algorithms For Multi Objective Optimization, Ozgu Turgut

Wayne State University Dissertations

In most real-life problems, the decision alternatives are evaluated with multiple conflicting criteria. The entire set of non-dominated solutions for practical problems is impossible to obtain with reasonable computational effort. Decision maker generally needs only a representative set of solutions from the actual Pareto front. First algorithm we present is for efficiently generating a well dispersed non-dominated solution set representative of the Pareto front which can be used for general multi objective optimization problem. The algorithm first partitions the criteria space into grids to generate reference points and then searches for non-dominated solutions in each grid. This grid-based search utilizes ...


Engineering Problem Solving And Sustained Learning: A Mixed Methods Study To Explore The Dynamics Of Engineering Knowledge Creation, Rachel Itabashi-Campbell Jan 2013

Engineering Problem Solving And Sustained Learning: A Mixed Methods Study To Explore The Dynamics Of Engineering Knowledge Creation, Rachel Itabashi-Campbell

Wayne State University Dissertations

This dissertation research explores processes by which engineering problem solving (EPS) results in sustained organizational learning. Approaching from a constructionist perspective, the study empirically examines the knowledge creation dynamics instigated by product-related problems using a mixed methods research approach. The research has identified the Japanese concept of ba, defined in this study as "shared experiential space," as a key construct that explains the phenomena of interest. A new framework that the study has developed, which interprets EPS as an epistemic journey to attain system-wide improvements, is highly complementary to the traditional structured routine based approaches to engineering operations and management ...


Optimization Of Strategic Planning Processes For Configurable Products: Considerations For Global Supply, Demand, And Sustainability Issues, Edward Lawrence Umpfenbach Jan 2013

Optimization Of Strategic Planning Processes For Configurable Products: Considerations For Global Supply, Demand, And Sustainability Issues, Edward Lawrence Umpfenbach

Wayne State University Dissertations

The assortment planning problem is to decide on the set of products that a retailer or manufacturer will offer to its customers to maximize profitability. While assortment planning research has been expanding in recent years, the current models are inadequate for the needs of a configurable product manufacturer. In particular, we address assortment planning for an automobile manufacturer. We develop models to integrate assortment planning and supply chain management, designed for use by a large automaker in its strategic planning phase. Our model utilizes a multinomial logit model transformed into a mixed integer linear program through the Charnes-Cooper transformation. It ...