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Full-Text Articles in Nanoscience and Nanotechnology

Multifunctional Nanoparticles In Cancer: In Vitro Characterization, In Vivo Distribution, Tingjun Lei Mar 2013

Multifunctional Nanoparticles In Cancer: In Vitro Characterization, In Vivo Distribution, Tingjun Lei

FIU Electronic Theses and Dissertations

A novel biocompatible and biodegradable polymer, termed poly(Glycerol malate co-dodecanedioate) (PGMD), was prepared by thermal condensation method and used for fabrication of nanoparticles (NPs). PGMD NPs were prepared using the single oil emulsion technique and loaded with an imaging/hyperthermia agent (IR820) and a chemotherapeutic agent (doxorubicin, DOX). The size of the void PGMD NPs, IR820-PGMD NPs and DOX-IR820-PGMD NPs were approximately 90 nm, 110 nm, and 125 nm respectively. An acidic environment (pH=5.0) induced higher DOX and IR820 release compared to pH=7.4. DOX release was also enhanced by exposure to laser, which increased the ...


Functions And Future Applications Of F1 Atpase As Nanobioengine - Powering The Nanoworld!, Sandip S. Magdum Jan 2013

Functions And Future Applications Of F1 Atpase As Nanobioengine - Powering The Nanoworld!, Sandip S. Magdum

Sandip S. Magdum

Recent nanotechnological revolution mandates astonishing imagination about future nanoworld. Nature has ability to create nanobiomolecules which can function in extraordinary way which can be used to produce nano hybrid systems. The opportunity to use such nanobiomolecules in combination of nanomechanical systems for development of novel nano hybrid systems for their various applications needs to explore in further nanotechnological development. F1 ATPase is a subunit of ATP synthase, which is one of the biomolecular structure works on the plasma membrane of the living cell. The reversible function of F1 ATPase gives a counterclockwise rotation of γ shaft by hydrolyzing ATP and ...