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Full-Text Articles in Nanoscience and Nanotechnology

The Optical Properties Of Spiky Gold Nanoshells, Simon Hastings Jan 2014

The Optical Properties Of Spiky Gold Nanoshells, Simon Hastings

Publicly Accessible Penn Dissertations

Plasmonic nanoparticles are a powerful and versatile tool for molecular sensing, drug delivery, and cancer treatment. When exposed to incident light, these nanoparticles have greatly increased far-field scattering and near-field enhancement. Spiky gold nanoshells are a recently developed class of nanoparticles composed of sharp gold spikes decorating a polystyrene core. Spiky nanoshells are synthesized using the templated surfactant-assisted seed growth method, which enables extensive control of the nanoparticle morphology. Here, it is shown that these particles have a tailorable far-field resonance, extremely uniform single-particle surface enhanced Raman scattering, and modal interference in dark-field microscopy measurements. Finite-difference time-domain simulations are performed ...


Virus-Size Nanoparticles Coated With A Synthetic "Self" Peptide Inhibit Phagocytic Clearance And Enhance Delivery Of An Anti-Cancer Drug, Pia Lorena Rodriguez Nunez Jan 2012

Virus-Size Nanoparticles Coated With A Synthetic "Self" Peptide Inhibit Phagocytic Clearance And Enhance Delivery Of An Anti-Cancer Drug, Pia Lorena Rodriguez Nunez

Publicly Accessible Penn Dissertations

Professional phagocytes are white blood cells of the innate immune system that protect humans and other animals from attacks by foreign pathogens by ingesting potentially harmful circulating particles. However, phagocytes such as macrophages may also attack elements that have been intentionally introduced into the body, such as implants, artificial tissues, artificial organs and vesicles bearing therapeutic agents, reducing their lifetime in the body. Nanoparticles and liposomes are similar in size to viruses, and are frequently decorated with antibodies for targeted therapeutics or imaging purposes. Although such particles are sufficiently small to avoid passive entrapment within capillaries in vivo, macrophages in ...


Synthesis And Self-Assembly Of Polymeric Hybrid Nanomaterials, Amanda C. Kamps Jan 2012

Synthesis And Self-Assembly Of Polymeric Hybrid Nanomaterials, Amanda C. Kamps

Publicly Accessible Penn Dissertations

The ability to construct functional polymeric hybrid nanomaterials is critically important for many applications. In this thesis I present the synthesis of amphiphilic polymers of various compositions including insulating coil-coil, semiconducting rod-coil, semiconducting brush-coil, and bioconjugated rod-coil polymers. The self-assembly of these polymers is presented along with methodologies for controlling the organization of nanomaterials and polymers towards the construction of functional hybrid materials with controllable structures and properties.

In this thesis, an analysis of the conditions necessary to stabilize the cooperative self-assembly of nanoparticles and amphiphilic block copolymers into a unique cavity-like structure is presented. This work reveals the mechanism ...


Monitoring Of Immune Cell Response To B Cell Depletion Therapy And Nerve Root Injury Using Spio Enhanced Mri, Daniel L. Thorek Dec 2009

Monitoring Of Immune Cell Response To B Cell Depletion Therapy And Nerve Root Injury Using Spio Enhanced Mri, Daniel L. Thorek

Publicly Accessible Penn Dissertations

Magnetic resonance (MR) is a robust platform for non-invasive, high-resolution anatomical imaging. However, MR imaging lacks the requisite sensitivity and contrast for imaging at the cellular level. This represents a clinical impediment to greater diagnostic accuracy. Recent advances have allowed for the in vivo visualization of populations and even of individual cells using superparamagnetic iron oxide (SPIO) MR contrast agents. These nanoparticles, commonly manifested as a core of a single iron oxide crystal or cluster of crystals coated in a biocompatible shell, function to shorten proton relaxation times. In MR imaging these constructs locally dephase protons, resulting in a decrease ...