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Full-Text Articles in Nanoscience and Nanotechnology
Theranostic Nanoparticles For The Treatment Of Cancer, Thomas Moore
Theranostic Nanoparticles For The Treatment Of Cancer, Thomas Moore
All Dissertations
The main focus of this research was to evaluate the ability of a novel multifunctional nanoparticle to mediate drug delivery and enable a non-invasive approach to measure drug release kinetics in situ for the treatment of cancer. These goals were approached by developing a nanoparticle consisting of an inorganic core (i.e. gadolinium sulfoxide doped with europium ions or carbon nanotubes). This was coated with an external amphiphilic polymer shell comprised of a biodegradable polyester (i.e. poly(lactide) or poly(glycolide)), and poly(ethylene glycol) block copolymer. In this system, the inorganic core mediates the imaging aspect, the relatively hydrophobic polyester encapsulates hydrophobic anti-cancer …
Neoadjuvant Therapy For Ovarian Cancer Using Bioglycogentm Nanoparticles Sbir Grant Proposal, Alexander E. Talamo
Neoadjuvant Therapy For Ovarian Cancer Using Bioglycogentm Nanoparticles Sbir Grant Proposal, Alexander E. Talamo
Nanoscale Science & Engineering (discontinued with class year 2014)
Project Summary Technical Abstract This Small Business Innovation Research Phase I project, presented by Talamo Inc., is to test an ovarian cancer therapeutic delivery system, comprised of a nanoscale biocompatible vesicle that carries a bioactive small interfering RNA molecule (siRNA), in vivio in mice. The siRNA has shown to reduce the expression of an enzyme (Sod2) that is highly expressed in multiple ovarian cancer types. The reduced expression of Sod2 will allow the tumor to become increasingly susceptible to chemotherapy agents, while simultaneously diminishing tumor progression. Research has proved that the nanoscale vesicle is non-toxic and in combination with siRNA …
Modification Of Nanostructures Via Laser Processing, Louis Franzel
Modification Of Nanostructures Via Laser Processing, Louis Franzel
Theses and Dissertations
Modification of nanostructures via laser processing is of great interest for a wide range of applications such as aerospace and the storage of nuclear waste. The primary goal of this dissertation is to improve the understanding of nanostructures through two primary routes: the modification of aerogels and pulsed laser ablation in ethanol. A new class of materials, patterned aerogels, was fabricated by photopolymerizing selected regions of homogeneous aerogel monoliths using visible light. The characterization and fabrication of functionally graded, cellular and compositionally anisotropic aerogels and ceramics is discussed. Visible light was utilized due to it’s minimal absorption and scattering by …
Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, Xiaochu Ding
Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, Xiaochu Ding
Dissertations, Master's Theses and Master's Reports - Open
This dissertation is related to the studies of functionalized nanoparticles for self-assembly and as controlled drug delivery system. The whole topic is composed of two parts. In the first part, the research was conducted to design and synthesize a new type of ionic peptide-functionalized copolymer conjugates for self-assembly into nanoparticle fibers and 3D scaffolds with the ability of multi-drug loading and governing the release rate of each drug for tissue engineering. The self-assembly study confirmed that such peptide-functionalized amphiphilic copolymers underwent different self-assembly behavior. The bigger nanoparticles were more easily assembled into nanoparticle fibers and 3D scaffolds with larger pore …