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Nanoscience and Nanotechnology Commons

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Theses/Dissertations

Nanofabrication

Iowa State University

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Full-Text Articles in Nanoscience and Nanotechnology

Electrostatic Actuation Based Modulation Of Polar Molecules And Associated Force Interaction Studies, Xiao Ma Jan 2013

Electrostatic Actuation Based Modulation Of Polar Molecules And Associated Force Interaction Studies, Xiao Ma

Graduate Theses and Dissertations

Seamless integration of artificial components with biological systems to form an elegant biotic-abiotic interface or smart surface has promising application potential in biomedical engineering. The specific aim of this study is to implement the actuation and modulation of binding behavior between biomolecules under electrostatic stimuli, and investigate the corresponding force interaction between the complementary pairs. The nanofabrication technology was utilized to establish the patterned binding pair of thrombin and DNA aptamer on gold substrate, and different electrical fields were applied on the system to evaluate electrostatic influence. The atomic force microscopy (AFM) surface imaging was then used to explicate the ...