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Articles 1 - 19 of 19

Full-Text Articles in Nanoscience and Nanotechnology

Genetic Editing Out The Tumor Growth Supressor Gene Trm9l In Colorectal Cancer Models Using Crispr-Cas9, Philip Blatner May 2017

Genetic Editing Out The Tumor Growth Supressor Gene Trm9l In Colorectal Cancer Models Using Crispr-Cas9, Philip Blatner

Nanoscale Science & Engineering (discontinued with class year 2014)

Clustered regularly interspaced short palindromic repeats (CRISPR) is a precise genetic engineering tool for genome editing. CRISPR utilizes guide RNA (gRNA) to find specific DNA sequences followed by a Cas9 nuclease to cut the DNA at a specific site. TRM9L is a tumor growth-suppresser gene that restricts the growth of some colorectal cancer cells by upregulating LIN9 expression. TRM9L expression is lost in some late stage colorectal cancers and cancer models (SW620). SW480 colorectal cancer cells express TRM9L and these cells are considered to be at the beginning of colorectal cancer development. The goal of my project was to use ...


Optimization And Modeling Of An Energy Harvesting Optical Micropropeller For Microfluidic Applications, Jacqueline Elwood May 2016

Optimization And Modeling Of An Energy Harvesting Optical Micropropeller For Microfluidic Applications, Jacqueline Elwood

Nanoscale Science & Engineering (discontinued with class year 2014)

The design and materials optimization of a optical micropropeller comprised of silver nanorods on a fused silica substrate was developed. A combination of surface plasmon resonance, thermophoretic and convective forces enable rotation of the micropropeller in an aqueous environment. This work aims to eliminate the dependence of optical micropropellers on the requirement for a light source by relying on a blackbody radiation energy harvesting principle. This energy harvesting principle is able to plasmonically excite noble metal nanorods of a specific aspect ratio at specific wavelengths that correspond to an ambient temperature. By investigating the dependence of the aspect ratio and ...


Development And Characterization Of Adhesive Hydrogels For Stem Cell Culture, Erin Byrne Rousseau May 2016

Development And Characterization Of Adhesive Hydrogels For Stem Cell Culture, Erin Byrne Rousseau

Nanoscale Science & Engineering (discontinued with class year 2014)

Pluripotent embryonic stem cells (ESCs) offer the unique capacity to differentiate into almost any cell type and have sweeping implications in both basic research and clinical applications. However, unregulated differentiation can cause issues, preventing ESCs from entering clinical research. In order to maximize ESC growth, three dimensional culturing has been utilized in order to have results more similar to in vivo conditions. In the case of alginate scaffolds, cell adhesion sites are missing from the matrix, leading to differentiation. We propose that the inclusion of adhesive polymer to the alginate scaffold will increase cell attachment and maintain pluripotency. The polymer ...


Predicting Structures And Properties Of Transition Metal Dichalcogenide Alloys Using Density Functional Theory, Lucas R. Bruzgulis May 2016

Predicting Structures And Properties Of Transition Metal Dichalcogenide Alloys Using Density Functional Theory, Lucas R. Bruzgulis

Nanoscale Science & Engineering (discontinued with class year 2014)

Workflows for computationally simulating transition metal dichalcogenides using density functional theoretic methods and cluster expansion were established, as implemented in the Quantum ESPRESSO and Alloy Theoretic Automated Toolkit computer codes, respectively. Effects of energy cutoff values and k-point density on convergence of DFT results were investigated for the MoS2 structure, and theoretic band structure calculations for MoS2 and WS2 were performed. The MoXW(1-X)S2 alloy system was also investigated using the maps code in the Alloy Theoretic Automated Toolkit in order to generate a composition vs energy plot. The application of Special Quasi-random Structures to further research into TMDC ...


Gold Nanoparticle Colorimetric Sensing Technology, Eve Borden May 2016

Gold Nanoparticle Colorimetric Sensing Technology, Eve Borden

Nanoscale Science & Engineering (discontinued with class year 2014)

No abstract provided.


Optimization And Modeling Of An Energy Harvesting Optical Micropropeller For Microfluidic Applications, Jerry Shih May 2016

Optimization And Modeling Of An Energy Harvesting Optical Micropropeller For Microfluidic Applications, Jerry Shih

Nanoscale Science & Engineering (discontinued with class year 2014)

Geometry for a plasmonically active micro-propeller is designed in Matlab using a Metallic Nano-Particle Boundary Element Method (MNPBEM) toolbox in order to predict its optical response in long wavelengths of electromagnetic radiation. Electric field maps are plotted to determine the feasibility generating torque using the energy harvesting principle. Results indicate electric field lines that would promote rotation and the scattering cross section would cause nano-rods sitting on the propeller to radiate thermal energy. COMSOL modeling is performed to model the evolution natural convection currents as a result of the nano-rod heating which is then optimized to further promote rotation of ...


Fundamental Interdiffusion Analysis Of Ruthenium And Cobalt Films, Bartlet Deprospo May 2016

Fundamental Interdiffusion Analysis Of Ruthenium And Cobalt Films, Bartlet Deprospo

Nanoscale Science & Engineering (discontinued with class year 2014)

No abstract provided.


Modeling Secondary Electron Trajectories In Scanning Electron Microscopes, Kevin Mcnamara, Joshua Miller May 2016

Modeling Secondary Electron Trajectories In Scanning Electron Microscopes, Kevin Mcnamara, Joshua Miller

Nanoscale Science & Engineering (discontinued with class year 2014)

The efficiency of secondary electron collection by a scanning electron microscope detector is not generally known, particularly as the electric field on the detector is varied. It is often assumed that the detector collects almost all of the secondary electrons emitted from the sample. This works seeks to better understand the mechanism of secondary electron collection by the detector in order to optimize collection efficiency. The benefit of collecting more secondary electrons is the enhancement of the signal-to-noise ratio, which means better quality images can be obtained, allowing us to better understand the relationship between secondary electron images and the ...


Size Controlled Formation Of A Collagen-Based Drug Delivery System, Leonardo Bezerra May 2016

Size Controlled Formation Of A Collagen-Based Drug Delivery System, Leonardo Bezerra

Nanoscale Science & Engineering (discontinued with class year 2014)

This study investigates and troubleshoots various factors involved in the generation of collagen-based particles, such as volume of solution, temperature, and incubation time for the purposes of a potential colorectal cancer targeting drug vehicle. The particles were generated via loading into a gel mold and show a 20-200 fold decrease in size compared to those created only under chemical means.


Graphene’S Electronic Surface States On Metal Substrates, Alex De Palma May 2016

Graphene’S Electronic Surface States On Metal Substrates, Alex De Palma

Nanoscale Science & Engineering (discontinued with class year 2014)

Graphene is a 2-­‐D sheet of sp2 bonded carbon atoms with exceptional electrical properties. Particularly, graphene has a very high carrier mobility (~200,000 cm2/V·∙s). This is largely due to graphene’s unique electronic structure, wherein charge carriers are effectively massless Dirac fermions. However, the unique electronic structure of graphene has been shown to be affected by the underlying substrate. In this study, we characterize the electronic structure of graphene on copper. Electron energy loss spectroscopy is employed to observe the surface plasmon excitations of graphene. A small pi plasmon excitation is observed, suggesting that the graphene ...


Modeling Secondary Electron Trajectories In Scanning Electron Microscopes, Joshua Miller, Kevin Mcnamara May 2016

Modeling Secondary Electron Trajectories In Scanning Electron Microscopes, Joshua Miller, Kevin Mcnamara

Nanoscale Science & Engineering (discontinued with class year 2014)

The efficiency of secondary electron collection by a scanning electron microscope detector is not generally known, particularly as the electric field on the detector is varied. It is often assumed that the detector collects almost all of the secondary electrons emitted from the sample. This works seeks to better understand the mechanism of secondary electron collection by the detector in order to optimize collection efficiency. The benefit of collecting more secondary electrons is the enhancement of the signal-to-noise ratio, which means better quality images can be obtained, allowing us to better understand the relationship between secondary electron images and the ...


Alloy Solute Interactions At Grain Boundaries And Nanoscale Interfaces In Copper, Luke Prestowitz May 2015

Alloy Solute Interactions At Grain Boundaries And Nanoscale Interfaces In Copper, Luke Prestowitz

Nanoscale Science & Engineering (discontinued with class year 2014)

To study grain boundary solute interactions we have developed recipes for co-electrodeposition of dilute copper alloys including Cu(Ni) and Cu(Co). Secondary Ion Mass Spectrometry (SIMS) was used to analyze the incorporation of solute into the copper film. In addition to the co-electrodeposition process we also used a drive-in diffusion model for Au, Ag, Co, and Ni. Atomic imaging in a scanning transmission electron microscope (STEM) was used to visualize and investigate solute at grain boundaries and interfaces in polygranular copper films. By understanding these interactions and pathways of alloying solutes in copper microstructures, we can more accurately predict ...


Organometallic Carboxylate Resists For Euv With High Sensitivity, James Passarelli May 2015

Organometallic Carboxylate Resists For Euv With High Sensitivity, James Passarelli

Nanoscale Science & Engineering (discontinued with class year 2014)

We have developed organometallic carboxylate compounds [RnM(O2CR’)2] capable of acting as negative-tone EUV resists. Overall, the best and fastest resists contain antimony, are pentavalent and the carboxylate group contains a polymerizable olefin (e.g. acrylate, methacrylate or styrenecarboxylate). Evidence suggests that high sensitivity is achieved through the polymerization of olefins in the exposed region. We have performed a systematic sensitivity study of molecules of the type RnM(O2CR’)2 where we have studied seven R groups, four main group metals (M), and three polymerizable carboxylate groups (O2CR’). We found that the greatest predictor of sensitivity of the RnSb ...


Bio Roll-Up: Self-Assembling Scaffolds For Tissue Engineering, Chase Austyn Brisbois May 2014

Bio Roll-Up: Self-Assembling Scaffolds For Tissue Engineering, Chase Austyn Brisbois

Nanoscale Science & Engineering (discontinued with class year 2014)

There is an unmet need for controlled, dynamic cell scaffolds that will generate 3-D monolayers of epithelial cells for medical research and tissue engineering. Here we describe a system that uses photoimageable and biocompatible HEMA-based hydrogel bilayers that self-assemble from 2-D substrates into 3-D tube-shaped structures. These structures are patterned on top of another layer that demonstrates an ability to anchor the assembled structure and control the direction and extent of selfassembly. Cell viability was determined by MTT assay which shows material components comparable with the positive control (80-110%). Finally, the masks used in the experiments herein were redesigned to ...


High Element Gold Nanorod Plasmonic Sensing Array For Harsh Environment Gas Detection Grant Proposal, Brian Janiszweski May 2013

High Element Gold Nanorod Plasmonic Sensing Array For Harsh Environment Gas Detection Grant Proposal, Brian Janiszweski

Nanoscale Science & Engineering (discontinued with class year 2014)

In order to acquire funding for scientific endeavors very specific grant proposal documents must be written and submitted. The following is an example of that. This project was very useful because my peers and I will undoubtedly have to write a grant of some type or another in our future careers. This specific proposal is a mock grant requesting money from the National Science Foundation to fund research into a gas sensor that utilizes gold nanostructures as sensing mechanism. The research done behind this project was performed over three semesters in the lab of Dr. Michael Carpenter form the College ...


Generation Of Saws In Ghz Range For Nanoscale Particle Removal, Leigh Kent Lydecker Iv May 2013

Generation Of Saws In Ghz Range For Nanoscale Particle Removal, Leigh Kent Lydecker Iv

Nanoscale Science & Engineering (discontinued with class year 2014)

In order to do research at CNSE, funding is required. Funding is achieved by submitting a grant proposal stating the background of the problem one hopes to address, a proposed solution, and sufficient information to prove success is achievable. These grant proposals follow a very particular format, which is extremely valuable to be familiar with in the scientific field of study. Therefore, learning to write a grant proposal for some of the work I have done during my undergraduate studies was proved a valuable learning experience. The following grant proposal is based on the work I have done during the ...


Neoadjuvant Therapy For Ovarian Cancer Using Bioglycogentm Nanoparticles Sbir Grant Proposal, Alexander E. Talamo May 2013

Neoadjuvant Therapy For Ovarian Cancer Using Bioglycogentm Nanoparticles Sbir Grant Proposal, Alexander E. Talamo

Nanoscale Science & Engineering (discontinued with class year 2014)

Project Summary Technical Abstract This Small Business Innovation Research Phase I project, presented by Talamo Inc., is to test an ovarian cancer therapeutic delivery system, comprised of a nanoscale biocompatible vesicle that carries a bioactive small interfering RNA molecule (siRNA), in vivio in mice. The siRNA has shown to reduce the expression of an enzyme (Sod2) that is highly expressed in multiple ovarian cancer types. The reduced expression of Sod2 will allow the tumor to become increasingly susceptible to chemotherapy agents, while simultaneously diminishing tumor progression. Research has proved that the nanoscale vesicle is non-toxic and in combination with siRNA ...


Advancements Towards Single Site Information Storage And Processing Using Hfo2 Resistive Random Access Memory (Reram), Michael Quinlan Hovish May 2013

Advancements Towards Single Site Information Storage And Processing Using Hfo2 Resistive Random Access Memory (Reram), Michael Quinlan Hovish

Nanoscale Science & Engineering (discontinued with class year 2014)

Resistive Random Access Memory (ReRAM) has attracted much attention among researchers due to its fast switching speeds, lower switching voltages, and feasible integration into industry compatible CMOS processing. These characteristics make ReRAM a viable candidate for next-generation Non- Volatile Memory. Transition-Metal-Oxides have been proven to be excellent materials for ReRAM applications. This work investigates the effect of various, post-deposition anneals (PDA) on the switching parameters of Ni/Cu/HfO2/TiN Resistive Memory Devices (RMD). Results are presented in the form of a Small Business Innovation Research (SBIR) grant proposal. The use of the SBIR format emphasizes understanding of the experimental ...


Metal Oxide Nanocomposite Nanoliter Reaction Chamber Fabrication And Applications For Harsh Environment Gas Sensing, Michael C. Briggs May 2013

Metal Oxide Nanocomposite Nanoliter Reaction Chamber Fabrication And Applications For Harsh Environment Gas Sensing, Michael C. Briggs

Nanoscale Science & Engineering (discontinued with class year 2014)

In order to perform research at the College of Nanoscale Science and Engineering, funding for the desired research is required. Undergraduates get around that by working under a graduate student or professor who is currently funded. For those who seek funding, they receive it by submitting a grant proposal stating the motivation for research, the background, and previous research done to support this new endeavor, as well as future research plans that will be possible with funding. These grant proposals follow certain formats depending on where the principal investigator is seeking funding. As part of the honors requirement for the ...