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Full-Text Articles in Nanoscience and Nanotechnology
Synthesis Of Polyethylene Glycol-Based Hydrogels And Silver/Gold Nanostructures For Biomedical Applications, Isabelle Ishimwe Niyonshuti
Synthesis Of Polyethylene Glycol-Based Hydrogels And Silver/Gold Nanostructures For Biomedical Applications, Isabelle Ishimwe Niyonshuti
Graduate Theses and Dissertations
This work focuses on the synthesis of biocompatible polyethylene glycol (PEG)-based hydrogels, silver nanoparticles (AgNPs), and silver-gold nanocages (Ag-AuNCs) for biomedical applications. The dissertation includes two parts with Part I on the work of PEG-based hydrogel for wound healing applications and Part II on the work of Ag/Au nanostructures for antimicrobial applications. Part I studies PEG-based hydrogel for the delivery of fibroblast growth factors (FGFs) for wound healing applications, aiming to overcome the challenge of designing hydrogels capable of the sustained release of bioactive FGFs. This research develops new biocompatible anionic injectable hydrogel formulations based on Poly (Oligo Ethylene Glycol …
Exploring Thermoresponsive Affinity Agents To Enhance Microdialysis Sampling Efficiency Of Proteins, Thaddeus Vasicek
Exploring Thermoresponsive Affinity Agents To Enhance Microdialysis Sampling Efficiency Of Proteins, Thaddeus Vasicek
Graduate Theses and Dissertations
Affinity agents increase microdialysis protein relative recovery, yet they have not seen widespread use within the microdialysis community due to their additional instrumentation requirements and prohibitive cost. This dissertation describes new affinity agents for microdialysis that require no additional instrumentation to use, have nearly 100% particle recovery, are 7 times more cost efficient than alternatives, and have low specificity enabling their use for a wide variety of proteins. Initially gold nanoparticles were chosen as an affinity ligand support due to their high surface area/volume ratio and colloidal stability. Poly (N-isopropylacrylamide) was immobilized to the gold nanoparticles, which served to sterically …