Open Access. Powered by Scholars. Published by Universities.®

Nanoscience and Nanotechnology Commons

Open Access. Powered by Scholars. Published by Universities.®

Open Access Dissertations

2015

Mechanical Engineering

Articles 1 - 1 of 1

Full-Text Articles in Nanoscience and Nanotechnology

Freezing-Induced Deformation Of Biomaterials In Cryomedicine, Altug Ozcelikkale Apr 2015

Freezing-Induced Deformation Of Biomaterials In Cryomedicine, Altug Ozcelikkale

Open Access Dissertations

Cryomedicine utilizes low temperature treatments of biological proteins, cells and tissues for cryopreservation, materials processing and cryotherapy. Lack of proper understanding of cryodamage that occurs during these applications remains to be the primary bottleneck for development of successful tissue cryopreservation and cryosurgery procedures. An engineering approach based on a view of biological systems as functional biomaterials can help identify, predict and control the primary cryodamage mechanisms by developing an understanding of underlying freezing-induced biophysical processes. In particular, freezing constitutes the main structural/mechanical origin of cryodamage and results in significant deformation of biomaterials at multiple length scales. Understanding of these ...