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Selected Works

2019

Articles 1 - 2 of 2

Full-Text Articles in Nanoscience and Nanotechnology

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali Sep 2019

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva™ Handihaler, Advair Diskus™, and Pulmicort™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …

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Quantifying Thermal Boundary Conductance Of 2d–3d Interfaces, Zlatan Aksamija, Cameron J. Foss Feb 2019

Quantifying Thermal Boundary Conductance Of 2d–3d Interfaces, Zlatan Aksamija, Cameron J. Foss

Zlatan Aksamija

Heat dissipation in next-generation electronics based on two-dimensional (2D) materials is a
critical issue in their development and implementation. A potential bottleneck for heat removal in
2D-based devices is the thermal pathway from the 2D layer into its supporting substrate. The choice
of substrate, its composition and structure, can strongly impact the thermal boundary conductance
(TBC). Here we investigate the temperature-dependent TBC of 42 interfaces formed between a
group of six 2D materials and seven crystalline and amorphous substrates. We use first-principles
density functional perturbation theory to calculate the full phonon dispersion of the 2D layers and
substrates and then …

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