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Full-Text Articles in Nanoscience and Nanotechnology

Engineering Novel Nanomaterials From Ultrasmall Gold Clusters For Use In Cancer Therapy, Elizabeth Marie Higbee Dempsey Jan 2019

Engineering Novel Nanomaterials From Ultrasmall Gold Clusters For Use In Cancer Therapy, Elizabeth Marie Higbee Dempsey

Publicly Accessible Penn Dissertations

One of the biggest hurdles in clinical therapy is ensuring that drugs have appropriate pharmacokinetic profiles; they must traffic to sites of interest and accumulate there at relevant concentrations, but must also be eliminated from tissues at a desirable rate. This is especially important in oncology because precise tumor locations may be unknown and therapeutics are often toxic to off-target healthy tissues. Nanoscale drug formulations provide a useful way to modulate and improve the behavior of drugs within biological systems. For example, gold nanoparticles (AuNPs) can be designed with physiochemical properties that allow them to traffic from the bloodstream into ...


Influence Of Surface Modification On Properties And Applications Of Complex Engineered Nanoparticles, Binghui Wang Jan 2013

Influence Of Surface Modification On Properties And Applications Of Complex Engineered Nanoparticles, Binghui Wang

Theses and Dissertations--Chemical and Materials Engineering

Complex engineered nanoparticles (CENPs) are being used on various applications. Their properties are different from those of neat nanoparticles. The dissertation explores these differences from four aspects: 1) Modify carbon nanomaterials’ inert surfaces and investigate the effect on thermal and rheological behavior of their dispersions; 2) Generate self-assembly bi-layer structure of oxide nanoparticles via surface modification; 3) Study interaction between lysozyme and different surface-charged ceria nanoparticles; 4) Investigate the biodistribution and transformations of CENPs in biological media.

An environment-friendly surface modification was developed to modify surfaces of carbon nanomaterials for increasing their affinity to non-polar fluid. It can offset formation ...