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EPITHELIAL-CELL LINE; PERFUSION-CULTURE; DUCTAL LAVAGE; ANATOMY; CANCER; NIPPLE

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Full-Text Articles in Nanoscience and Nanotechnology

Breast On-A-Chip: Mimicry Of The Channeling System Of The Breast For Development Of Theranostics, Meggie Grafton, Lei Wang, Pierre-Alexandre Vidi, James Leary, Sophie Lelievre Dec 2012

Breast On-A-Chip: Mimicry Of The Channeling System Of The Breast For Development Of Theranostics, Meggie Grafton, Lei Wang, Pierre-Alexandre Vidi, James Leary, Sophie Lelievre

Dr Lei Wang

Improved detection and therapy of breast neoplasia might benefit from nanodevices traveling inside mammary ducts. However, the decreasing size of branched mammary ducts prevents access to remote areas of the ductal system using a pressure-driven fluid-based approach. Magnetic field guidance of superparamagnetic submicron particles (SMPs) in a stationary fluid might provide a possible alternative but it is critical to first reproduce the breast ductal system to assess the use of such devices for future therapeutic & diagnostic ("theranostic'') purposes. Here we describe the engineering of a portion of a breast ductal system using polydimethylsiloxane (PDMS) microfluidic channels with a total volume ...