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Cantilever Deflection Associated With Hybridization Of Monomolecular Dna Film, Yue Zhao, Baskar Ganapathysubramanian, Pranav Shrotriya Feb 2012

Cantilever Deflection Associated With Hybridization Of Monomolecular Dna Film, Yue Zhao, Baskar Ganapathysubramanian, Pranav Shrotriya

Mechanical Engineering Publications

Recent experiments show that specific binding between a ligand and surface immobilized receptor, such as hybridization of single stranded DNA immobilized on a microcantilever surface, leads to cantilever deflection. The binding-induced deflection may be used as a method for detection of biomolecules, such as pathogens and biohazards. Mechanical deformation induced due to hybridization of surface-immobilized DNA strands is a commonly used system to demonstrate the efficacy of microcantilever sensors. To understand the mechanism underlying the cantilever deflections, a theoretical model that incorporates the influence of ligand/receptor complex surface distribution and empirical interchain potential is developed to predict the binding-induced ...