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- Keyword
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- CANCER; NANOPARTICLES; THERAPY; ABSORPTION; GROWTH; RADIATION; CLUSTERS; LIGHT; SHAPE; SIZE (1)
- FOLIC-ACID FORTIFICATION; METASTATIC BREAST-CANCER; FOLATE RECEPTOR; OVARIAN-CANCER; PERIPHERAL-BLOOD; BINDING; TISSUES; ENDOCYTOSIS; CARCINOMAS; MICROSCOPY (1)
- Folate conjugates; in vivo imaging; multiphoton microscopy; metastasis; cancer diagnosis (1)
- Folate receptor; hyperthermia; imaging; nanorods; nonlinear optical microscopy; plasmon resonance; targeted therapy (1)
Articles 1 - 3 of 3
Full-Text Articles in Nanoscience and Nanotechnology
Gold Nanorods Mediate Tumor Cell Death By Compromising Membrane Integrity, Ling Tong, Yan Zhao, Terry B. Huff, Matthew N. Hansen, Alexander Wei, Ji-Xin Cheng
Gold Nanorods Mediate Tumor Cell Death By Compromising Membrane Integrity, Ling Tong, Yan Zhao, Terry B. Huff, Matthew N. Hansen, Alexander Wei, Ji-Xin Cheng
Other Nanotechnology Publications
Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.
In Vivo Quantitation Of Rare Circulating Tumor Cells By Multiphoton Intravital Flow Cytometry, Wei He, Haifeng Wang, Lynn C. Hartmann, Ji-Xin Cheng, Phillip S. Low
In Vivo Quantitation Of Rare Circulating Tumor Cells By Multiphoton Intravital Flow Cytometry, Wei He, Haifeng Wang, Lynn C. Hartmann, Ji-Xin Cheng, Phillip S. Low
Other Nanotechnology Publications
Quantitation of circulating tumor cells (CTCs) constitutes an emerging tool for the diagnosis and staging of cancer, assessment of response to therapy, and evaluation of residual disease after surgery. Unfortunately, no existing technology has the sensitivity to measure the low numbers of tumor cells (< 1 CTC per ml of whole blood) that characterize minimal levels of disease. We present a method, intravital flow cytometry, that noninvasively counts rare CTCs in vivo as they flow through the peripheral vasculature. The method involves i.v. injection of a tumor-specific fluorescent ligand followed by multiphoton fluorescence imaging of superficial blood vessels to quantitate the flowing CTCs. Studies in mice with metastatic tumors demonstrate that CTCs can be quantitated weeks before metastatic disease is detected by other means. Analysis of whole blood samples from cancer patients further establishes that human CTCs can be selectively labeled and quantitated when present at approximate to 2 CTCs per ml, opening opportunities for earlier assessment of metastatic disease.
Hyperthermic Effects Of Gold Nanorods On Tumor Cells, Terry B. Huff, Ling Tong, Matthew N. Hansen, Ji-Xin Cheng, Alexander Wei
Hyperthermic Effects Of Gold Nanorods On Tumor Cells, Terry B. Huff, Ling Tong, Matthew N. Hansen, Ji-Xin Cheng, Alexander Wei
Other Nanotechnology Publications
Plasmon-resonant gold nanorods, which have large absorption cross sections at near-infrared frequencies, are excellent candidates as multifunctional agents for image-guided therapies based on localized hyperthermia. The controlled modification of the surface chemistry of the nanorods is of critical importance, as issues of cell-specific targeting and nonspecific uptake must be addressed prior to clinical evaluation. Nanorods coated with cetyltrimethylammonium bromide (a cationic surfactant used in nanorod synthesis) are internalized within hours into KB cells by a nonspecific uptake pathway, whereas the careful removal of cetyltrimethylammonium bromide from nanorods functionalized with folate results in their accumulation on the cell surface over the …