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Articles 1 - 30 of 43

Full-Text Articles in Nanoscience and Nanotechnology

Sense–Analyze–Respond–Actuate (Sara) Paradigm: Proof Of Concept System Spanning Nanoscale And Macroscale Actuation For Detection Of Escherichia Coli In Aqueous Media, Cassie A. Giacobassi, Daniela A. Oliveira, Cicero C. Pola, Dong Xiang, Yifan Tang, Shoumen Palit Austin Datta, Eric S. Mclamore, Carmen L. Gomes Jan 2021

Sense–Analyze–Respond–Actuate (Sara) Paradigm: Proof Of Concept System Spanning Nanoscale And Macroscale Actuation For Detection Of Escherichia Coli In Aqueous Media, Cassie A. Giacobassi, Daniela A. Oliveira, Cicero C. Pola, Dong Xiang, Yifan Tang, Shoumen Palit Austin Datta, Eric S. Mclamore, Carmen L. Gomes

Mechanical Engineering Publications

Foodborne pathogens are a major concern for public health. We demonstrate for the first time a partially automated sensing system for rapid (~17 min), label-free impedimetric detection of Escherichia coli spp. in food samples (vegetable broth) and hydroponic media (aeroponic lettuce system) based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) nanobrushes. This proof of concept (PoC) for the Sense-Analyze-Respond-Actuate (SARA) paradigm uses a biomimetic nanostructure that is analyzed and actuated with a smartphone. The bio-inspired soft material and sensing mechanism is inspired by binary symbiotic systems found in nature, where low concentrations of bacteria are captured from complex matrices by brush actuation ...


Size-Dependent Inhibitory Effects Of Antibiotic Nanocarriers On Filamentation Of E. Coli, Preeyaporn Songkiatisak, Feng Ding, Pavan Kumar Cherukuri, Xiao-Hong Nancy Xu May 2020

Size-Dependent Inhibitory Effects Of Antibiotic Nanocarriers On Filamentation Of E. Coli, Preeyaporn Songkiatisak, Feng Ding, Pavan Kumar Cherukuri, Xiao-Hong Nancy Xu

Chemistry & Biochemistry Faculty Publications

Multidrug membrane transporters exist in both prokaryotic and eukaryotic cells and cause multidrug resistance (MDR), which results in an urgent need for new and more effective therapeutic agents. In this study, we used three different sized antibiotic nanocarriers to study their mode of action and their size-dependent inhibitory effects against Escherichia coli (E. coli). Antibiotic nanocarriers (AgMUNH–Oflx NPs) with 8.6 × 102, 9.4 × 103 and 6.5 × 105 Oflx molecules per nanoparticle (NP) were prepared by functionalizing Ag NPs (2.4 ± 0.7, 13.0 ± 3.1 and 92.6 ± 4.4 nm) with a ...


Quantifying Wicking In Functionlized Surfaces, Maureen Winter, Ryan Regan, Alfred Tsubaki, Craig Zuhlke, Dennis Alexander, George Gogos Apr 2020

Quantifying Wicking In Functionlized Surfaces, Maureen Winter, Ryan Regan, Alfred Tsubaki, Craig Zuhlke, Dennis Alexander, George Gogos

UCARE Research Products

Wicking remains the enigmatic key factor in many research areas. From boiling in power plants, to anti-icing on plane wings, to medical instruments, to heat pipes, efficiency and safety depend on how quickly a surface becomes wet. Yet wicking remains difficult to quantify and define as a property of the surface. This experiment strives to measure the wicking property by examining the rate that a liquid can be pulled out of a container. A superhydrophilic surface is placed in contact with the liquid at the bottom of a tube so that the volume flow rate across the surface can be ...


Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das Mar 2020

Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das

Doctoral Dissertations

Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for ...


Synthesis And Characterization Of Rapidly-Degrading Polyanhydrides As Vaccine Adjuvants, Sean M. Kelly, Akash Mitra, Srishti Mathur, Balaji Narasimhan Dec 2019

Synthesis And Characterization Of Rapidly-Degrading Polyanhydrides As Vaccine Adjuvants, Sean M. Kelly, Akash Mitra, Srishti Mathur, Balaji Narasimhan

Chemical and Biological Engineering Publications

There is a currently a need to develop adjuvants that are best suited to simultaneously enhance immune responses, induce immunologic memory, improve patient compliance (i.e., reduce doses and inflammation), and provide vaccine shelf stability for stockpiling and global deployment to challenging environments. Biodegradable polyanhydrides have been investigated extensively to overcome such challenges. It has been shown that controlling copolymer composition can result in chemistry-dependent immunomodulatory capabilities. These studies have revealed that copolymers rich in sebacic acid (SA) are highly internalized by antigen presenting cells and confer improved shelf stability of encapsulated proteins, while copolymers rich in 1,8-bis(p-carboxyphenoxy ...


Bioinspired Complex Nanoarchitectures By Dna Supramolecular Polymerization, Laura A. Lanier Oct 2019

Bioinspired Complex Nanoarchitectures By Dna Supramolecular Polymerization, Laura A. Lanier

Doctoral Dissertations

Bioinspired nanoarchitectures are of great interest for applications in fields such as nanomedicine, tissue engineering, and biosensing. With this interest, understanding how the physical properties of these complex nanostructures relate to their function is increasingly important. This dissertation describes the creation of complex nanoarchitectures with controlled structure and the investigation of the effect of nanocarrier physical properties on cell uptake for applications in nanomedicine.

DNA self-assembly by supramolecular polymerization was chosen to create complex nanostructures of controlled architectures. We demonstrated that the supramolecular polymerization of DNA known as hybridization chain reaction (HCR) is in fact a living polymerization. The living ...


Engineering Nanomaterials For Imaging And Therapy Of Bacteria And Biofilm-Associated Infections, Akash Gupta Oct 2019

Engineering Nanomaterials For Imaging And Therapy Of Bacteria And Biofilm-Associated Infections, Akash Gupta

Doctoral Dissertations

Infections caused by multidrug-resistant (MDR) bacteria pose a serious global burden of mortality, causing thousands of deaths each year. The “superbug” risk is further exacerbated by chronic infections generated from antibiotic-resistant biofilms that are highly resistant to available treatments. Synthetic macromolecules such as polymers and nanoparticles have emerged as promising antimicrobials. Moreover, ability to modulate nanomaterial interaction with bacterial cellular systems plays a pivotal role in improving the efficacy of the strategy.

In the initial studies on engineering nanoparticle surface chemistry, I investigated the role played by surface ligands in determining the antimicrobial activity of the nanoparticles. In further study ...


Fabrication Of High-Resolution Graphene-Based Flexible Electronics Via Polymer Casting, Metin Uz, Kyle Jackson, Maxsam S. Donta, Juhyung Jung, Matthew T. Lentner, John A. Hondred, Jonathan C. Claussen, Surya K. Mallapragada Jul 2019

Fabrication Of High-Resolution Graphene-Based Flexible Electronics Via Polymer Casting, Metin Uz, Kyle Jackson, Maxsam S. Donta, Juhyung Jung, Matthew T. Lentner, John A. Hondred, Jonathan C. Claussen, Surya K. Mallapragada

Chemical and Biological Engineering Publications

In this study, a novel method based on the transfer of graphene patterns from a rigid or flexible substrate onto a polymeric film surface via solvent casting was developed. The method involves the creation of predetermined graphene patterns on the substrate, casting a polymer solution, and directly transferring the graphene patterns from the substrate to the surface of the target polymer film via a peeling-off method. The feature sizes of the graphene patterns on the final film can vary from a few micrometers (as low as 5 µm) to few millimeters range. This process, applied at room temperature, eliminates the ...


The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport, Haneen Martinez Mar 2019

The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport, Haneen Martinez

Nanoscience and Microsystems ETDs

Nanoscale transport using the kinesin-microtubule (MT) biomolecular system has been successfully used in a wide range of nanotechnological applications including self-assembly, nanofluidic transport, and biosensing. Most of these applications use the ‘gliding motility geometry’, in which surface-adhered kinesin motors attach and propel MT filaments across the surface, a process driven by ATP hydrolysis. It has been demonstrated that active assembly facilitated by these biomolecular motors results in complex, non-equilibrium nanostructures currently unattainable through conventional self-assembly methods. In particular, MTs functionalized with biotin assemble into rings and spools upon introduction of streptavidin and/or streptavidin-coated nanoparticles. Upon closer examination of these ...


Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang Mar 2019

Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang

Doctoral Dissertations

Proteins have intrinsic molecular properties that are highly useful for materials applications, especially for biomaterials. My research has focused on translating these molecular properties to materials surface behavior. In one approach, I developed a fluorous-based thermal treatment strategy to generate stable thin films from a variety of naturally abundant proteins. The different surface properties generated from the choice of protein were utilized to modulate cell-surface interactions, prevent bacterial adhesions, and control drug loading/release. I have used nanoimprint lithography to generate patterned protein films for cell alignment. Coupling with inkjet printing deposition, I have fabricated mixed protein films with spatial ...


Direct Patterning Of Nature-Inspired Surfaces For Biointerfacial Applications, Feyza Dundar Mar 2019

Direct Patterning Of Nature-Inspired Surfaces For Biointerfacial Applications, Feyza Dundar

Doctoral Dissertations

There are three major challenges for the design of patterned surfaces for biointerfacial applications: (i) durability of antibacterial/antifouling mechanisms, (ii) mechanical durability, and (iii) lifetime of the master mold for mass production of patterned surfaces. In this dissertation, we describe our contribution for the development of each of these challenges.

The bioinspired surface, Sharklet AFTM, has been shown to reduce bacterial attachment via a biocide-free structure-property relationship effectively. Unfortunately, the effectiveness of polymer-based sharkskin surfaces is challenged over the long term by both eventual bacteria accumulation and a lack of mechanical durability. To address these common modes of ...


Nanoharvesting And Delivery Of Bioactive Materials Using Engineered Silica Nanoparticles, Md Arif Khan Jan 2019

Nanoharvesting And Delivery Of Bioactive Materials Using Engineered Silica Nanoparticles, Md Arif Khan

Theses and Dissertations--Chemical and Materials Engineering

Mesoporous silica nanoparticles (MSNPs) possess large surface areas and ample pore space that can be readily modified with specific functional groups for targeted binding of bioactive materials to be transported through cellular barriers. Engineered silica nanoparticles (ESNP) have been used extensively to deliver bio-active materials to target intracellular sites, including as non-viral vectors for nucleic acid (DNA/RNA) delivery such as for siRNA induced interference. The reverse process guided by the same principles is called “nanoharvesting”, where valuable biomolecules are carried out and separated from living and functioning organisms using nano-carriers. This dissertation focuses on ESNP design principles for both ...


New Approach To Electron Microscopy Imaging Of Gel Nanocomposites In Situ, Alejandra Londono-Calderon, Srikanth Nayak, Curtis L. Mosher, Surya K. Mallapragada, Tanya Prozorov Jan 2019

New Approach To Electron Microscopy Imaging Of Gel Nanocomposites In Situ, Alejandra Londono-Calderon, Srikanth Nayak, Curtis L. Mosher, Surya K. Mallapragada, Tanya Prozorov

Chemical and Biological Engineering Publications

Characterization of Au-nanocomposites is routinely done with scattering techniques where the structure and ordering of nanoparticles can be analyzed. Imaging of Poloxamer gel-based Au-nanocomposites is usually limited to cryo-TEM imaging of cryo-microtomed thin sections of the specimen. While this approach is applicable for imaging of the individual nanoparticles and gauging their size distribution, it requires altering the state of the specimen and is prone to artifacts associated with preparation protocols. Use of Scanning Transmission Electron Microscopy (S/TEM) with fluid cell in situ provides an opportunity to analysis of these complex materials in their hydrated state with nanometer resolution, yet ...


Treatment Of Neurodegenerative Disorders Through The Blood-Brain Barrier Using Nanocarriers, Nitya Poovaiah, Zahra Davoudi, Haisheng Peng, Benjamin Schlichtmann, Surya K. Mallapragada, Balaji Narasimhan, Qun Wang Aug 2018

Treatment Of Neurodegenerative Disorders Through The Blood-Brain Barrier Using Nanocarriers, Nitya Poovaiah, Zahra Davoudi, Haisheng Peng, Benjamin Schlichtmann, Surya K. Mallapragada, Balaji Narasimhan, Qun Wang

Chemical and Biological Engineering Publications

Neurodegenerative diseases refer to disorders of the central nervous system (CNS) that are caused by neuronal degradations, dysfunctions, or death. Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease (APHD) are regarded as the three major neurodegenerative diseases. There is a vast body of literature on the causes and treatments of these neurodegenerative diseases. However, the main obstacle in developing an effective treatment strategy is the permeability of the treatment components to the blood-brain barrier (BBB). Several strategies have been developed to improve this obstruction. For example, nanomaterials facilitate drug delivery to the BBB due to their size. They ...


Soft-Microrobotics: The Manipulation Of Alginate Artificial Cells, Samuel Sheckman May 2018

Soft-Microrobotics: The Manipulation Of Alginate Artificial Cells, Samuel Sheckman

Mechanical Engineering Research Theses and Dissertations

In this work, the approach to the manipulation of alginate artificial cell soft-microrobots, both individually and in swarms is shown. Fabrication of these artificial cells were completed through centrifugation, producing large volumes of artificial cells, encapsulated with superparamagnetic iron oxide nanoparticles; these artificial cells can be then externally stimulated by an applied magnetic field. The construction of a Permeant Magnet Stage (PMS) was produced to manipulate the artificial cells individually and in swarms. The stage functionalizes the permanent magnet in the 2D xy-plane. Once the PMS was completed, Parallel self-assembly (Object Particle Computation) using swarms of artificial cells in complex ...


Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed Dec 2017

Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed

Electronic Thesis and Dissertation Repository

The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of ...


Transport Of Water And Ions Through Single-Walled Armchair Carbon Nanotubes: A Molecular Dynamics Study, Michelle Patricia Aranha Dec 2017

Transport Of Water And Ions Through Single-Walled Armchair Carbon Nanotubes: A Molecular Dynamics Study, Michelle Patricia Aranha

Doctoral Dissertations

The narrow hydrophobic interior of a carbon nanotube (CNT) poses a barrier to the transport of water and ions, and yet, unexpectedly, numerous experimental and simulation studies have confirmed fast water transport rates comparable to those seen in biological aquaporin channels. These outstanding features of high water permeability and high solute rejection of even dissolved ions that would typically require a lot of energy for separation in commercial processes makes carbon nanotubes an exciting candidate for desalination membranes. Extending ion exclusion beyond simple mechanical sieving by the inclusion of electrostatics via added functionality to the nanotube bears promise to not ...


Tunable Nanocomposite Membranes For Water Remediation And Separations, Sebastián Hernández Sierra Jan 2017

Tunable Nanocomposite Membranes For Water Remediation And Separations, Sebastián Hernández Sierra

Theses and Dissertations--Chemical and Materials Engineering

Nano-structured material fabrication using functionalized membranes with polyelectrolytes is a promising research field for water pollution, catalytic and mining applications. These responsive polymers react to external stimuli like temperature, pH, radiation, ionic strength or chemical composition. Such nanomaterials provide novel hybrid properties and can also be self-supported in addition to the membranes.

Polyelectrolytes (as hydrogels) have pH responsiveness. The hydrogel moieties gain or lose protons based on the pH, displaying swelling properties. These responsive materials can be exploited to synthesize metal nanoparticles in situ using their functional groups, or to immobilize other polyelectrolytes and biomolecules. Due to their properties, these ...


Electrospinning Novel Aligned Polymer Fiber Structures For Use In Neural Tissue Engineering, Rachel Martin Jan 2017

Electrospinning Novel Aligned Polymer Fiber Structures For Use In Neural Tissue Engineering, Rachel Martin

Dissertations, Master's Theses and Master's Reports

A suitable tissue scaffold to support and assist in the repair of damaged tissues or cells is important for success in clinical trials and for injury recovery. Electrospinning can create a variety of polymer nanofibers and microfibers, and is being widely used to produce experimental tissue scaffolds for neural applications. This dissertation examines various approaches by which electrospinning is being used for neural tissue engineering applications for the repair of injuries to the central nervous system (CNS) and the peripheral nervous system (PNS). Due to the poor regeneration of neural tissues in the event of injury, tissue scaffolds are being ...


Protein Patterns Template Arrays Of Magnetic Nanoparticles, Srikanth Nayak, Honghu Zhang, Xunpei Liu, Shuren Feng, Pierre Palo, Marit Nilsen-Hamilton, Mufit Akinc, Surya K. Mallapragada Jun 2016

Protein Patterns Template Arrays Of Magnetic Nanoparticles, Srikanth Nayak, Honghu Zhang, Xunpei Liu, Shuren Feng, Pierre Palo, Marit Nilsen-Hamilton, Mufit Akinc, Surya K. Mallapragada

Ames Laboratory Accepted Manuscripts

Controlling the morphology of magnetic nanoparticles and their spatial arrangement is crucial for manipulating their functional properties. The commonly available inorganic processes for the synthesis of uniform magnetic nanoparticles typically require extreme reaction conditions such as high temperatures or harsh reagents, rendering them unsuitable for making functionalized magnetic nanoparticles with tunable properties controlled by biomolecules. Biomimetic procedures, inspired by the production of uniform magnetite and greigite crystals in magnetotactic bacteria, provide an alternative method, which can allow synthesis and spatial arrangement under ambient conditions. Mms6, an amphiphilic protein found in magnetosome membranes in Magnetospirillum magneticum strain AMB-1, can control the ...


Inter-Droplet Membranes For Mechanical Sensing Applications, Nima Tamaddoni Jahromi May 2016

Inter-Droplet Membranes For Mechanical Sensing Applications, Nima Tamaddoni Jahromi

Doctoral Dissertations

This dissertation combines self-assembly phenomena of amphiphilic molecules with soft materials to create and characterize mechanoelectrical transducers and sensors whose sensing elements are thin-film bioinspired membranes comprised of phospholipids or amphiphilic polymers. We show that the structures of these amphiphilic molecules tune the mechanical and electrical properties of these membranes. We show that these properties affect the mechanoelectrical sensing characteristic and range of operation of these membrane transducers. In the experiments, we construct and characterize a membrane-based hair cell embodiment that enables the membrane to be responsive to mechanical perturbations of the hair. The resulting oscillations of membranes formed between ...


Fiber Based Approaches As Medicine Delivery Systems, Farrokh Sharifi, Avinash C. Sooriyarachchi, Hayriye Altural, Reza Montazami, Marissa Nichole Rylander, Nicole Nastaran Hashemi Jan 2016

Fiber Based Approaches As Medicine Delivery Systems, Farrokh Sharifi, Avinash C. Sooriyarachchi, Hayriye Altural, Reza Montazami, Marissa Nichole Rylander, Nicole Nastaran Hashemi

Mechanical Engineering Publications

The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro- and nanofibers for this purpose. The reasons for this growing interest include these materials’ high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning ...


Doping Plasmon-Enhanced Tio2 With Zirconia To Improve Solar Energy Harvesting In Dye-Sensitized Solar Cells, Anastasia Pasche Dec 2015

Doping Plasmon-Enhanced Tio2 With Zirconia To Improve Solar Energy Harvesting In Dye-Sensitized Solar Cells, Anastasia Pasche

Electronic Thesis and Dissertation Repository

Solar energy is a promising solution towards meeting the world’s ever-growing energy demand. Dye-sensitized solar cells (DSSCs) are hybrid organic-inorganic solar cells with potential for commercial application, but are plagued by inefficiency due to their poor sunlight absorption. Silver nanoparticles have been shown to enhance the absorptive properties of DSSCs, but their plasmonic resonance causes local hot spots, resulting in cell deterioration. This thesis studies the mitigation of thermal energy loss of plasmon-enhanced DSSCs by the co-incorporation of zirconia, a well-known thermostabilizer, into the cell’s photoactive material. TiO2 was also synthesized using green bio-sourced solvents in supercritical CO2 ...


Application Of 3d Printing Technology In Porous Anode Fabrication For Enhanced Power Output Of Microbial Fuel Cells, Bin Bian Sep 2015

Application Of 3d Printing Technology In Porous Anode Fabrication For Enhanced Power Output Of Microbial Fuel Cells, Bin Bian

Electronic Thesis and Dissertation Repository

Microbial fuel cells (MFCs) are widely researched for application in wastewater treatment. However, the current anodes used in MFCs often suffer from high fabrication cost and uncontrollable pore sizes. In this thesis, three-dimensional printing technique was utilized to fabricate anodes with different micro pore sizes for MFCs. Copper coating and carbonization were applied to the printed polymer anodes to increase the conductivity and specific surface area. Voltages of MFCs with various anodes were measured as well as other electrochemical tests such as linear sweep voltammetry and electrochemical impedance spectroscopy. 3D copper porous anode produced higher maximum voltages and power densities ...


Functional Nanostructures From Nanoparticle Building Blocks, Jimmy Lawrence Mar 2015

Functional Nanostructures From Nanoparticle Building Blocks, Jimmy Lawrence

Doctoral Dissertations

Advances in the synthetic strategies of engineered nanomaterials, multifunctional molecules and polymers have opened pathways for the development of functional nanomaterials having unique optoelectronic, mechanical, and biological properties. By designing the chemistry of surface ligands, the organic interface of nanoparticles, one can further the versatility and utilization of engineered nanomaterials, opening pathways for breakthroughs in sensing, catalysis, and delivery using nanomaterials.

This thesis describes the synthesis and characterization of small molecule and polymer ligand functionalized inorganic nanoparticles (e.g., metal, semiconducting). Embedding specific chemical functionality into the ligand periphery of nanoparticles enables the resulting functional nanoparticles to react selectively with ...


Biomimetic Oral Mucin From Polymer Micelle Networks, Sundar Prasanth Authimoolam Jan 2015

Biomimetic Oral Mucin From Polymer Micelle Networks, Sundar Prasanth Authimoolam

Theses and Dissertations--Chemical and Materials Engineering

Mucin networks are formed by the complexation of bottlebrush-like mucin glycoprotein with other small molecule glycoproteins. These glycoproteins create nanoscale strands that then arrange into a nanoporous mesh. These networks play an important role in ensuring surface hydration, lubricity and barrier protection. In order to understand the functional behavior in mucin networks, it is important to decouple their chemical and physical effects responsible for generating the fundamental property-function relationship. To achieve this goal, we propose to develop a synthetic biomimetic mucin using a layer-by-layer (LBL) deposition approach. In this work, a hierarchical 3-dimensional structures resembling natural mucin networks was generated ...


Application Of Scanning Angle Raman Spectroscopy For Determining The Location Of Buried Polymer Interfaces With Tens Of Nanometer Precision, Craig A. Damin, Vy H.T. Nguyen, Auguste S. Niyibizi, Emily A. Smith Jan 2015

Application Of Scanning Angle Raman Spectroscopy For Determining The Location Of Buried Polymer Interfaces With Tens Of Nanometer Precision, Craig A. Damin, Vy H.T. Nguyen, Auguste S. Niyibizi, Emily A. Smith

Chemistry Publications

Near-infrared scanning angle (SA) Raman spectroscopy was utilized to determine the interface location in bilayer films (a stack of two polymer layers) of polystyrene (PS) and polycarbonate (PC). Finite-difference-time-domain (FDTD) calculations of the sum square electric field (SSEF) for films with total bilayer thicknesses of 1200–3600 nm were used to construct models for simultaneously measuring the film thickness and the location of the buried interface between the PS and PC layers. Samples with total thicknesses of 1320, 1890, 2300, and 2750 nm and varying PS/PC interface locations were analyzed using SA Raman spectroscopy. Comparing SA Raman spectroscopy and ...


Optical Resonators And Fiber Tapers As Transducers For Detection Of Nanoparticles And Bio-Molecules, Huzeyfe Yilmaz Aug 2014

Optical Resonators And Fiber Tapers As Transducers For Detection Of Nanoparticles And Bio-Molecules, Huzeyfe Yilmaz

Engineering and Applied Science Theses & Dissertations

In recent years, detection of biological interactions on single molecule level has aspired many researchers to investigate several optical, chemical, electrical and mechanical sensing tools. Among these tools, toroidal optical resonators lead the way in detection of the smallest particle/molecule with the real time measurements. In this work, bio-sensing capabilities of toroidal optical resonators are investigated. Bio-sensing is realized via measuring the analyte-antigen interaction while the antigen is immobilized through a novel functionalization method.

Not long ago, detection of single nanoparticles using optical resonators has been accomplished however the need for cost-effective and practical transducers demands simpler tools. A ...


Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang Aug 2014

Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges ...


Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes Jun 2014

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual ...