Mining Engineering Commons^™

Nanometer Ultrastructural Brain Damage Following Low Intensity Primary Blast Wave Exposure, Hailong Song, Landry M. Konan, Jiankun Cui, Catherine E. Johnson, Graham K. Hubler, Ralph G. Depalma, Zezong Gu

Mining Engineering Faculty Research & Creative Works

Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast mediated pathophysiology upon later neurobehavioral disorders has been controversial. Developing a military preclinical blast model to simulate the pathophysiology of human blast injury is an important first step. This article provides an overview of primary blast effects and perspectives of our recent studies demonstrating ultrastructural changes in the brain and behavioral disorders resulting from open-field blast exposures up to 46.6 kPa using a murine model. The model is scalable and …