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Stress And Strain Adaptation In Load-Dependent Remodeling Of The Embryonic Left Ventricle, Christine Buffinton
Stress And Strain Adaptation In Load-Dependent Remodeling Of The Embryonic Left Ventricle, Christine Buffinton
Christine M Buffinton
Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology …