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Microfluidics

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Full-Text Articles in Mechanical Engineering

3d Printing A Microfluidic Chip Capable Of Droplet Emulsion Using Ninjaflex Filament, Robert Andrews May 2019

3d Printing A Microfluidic Chip Capable Of Droplet Emulsion Using Ninjaflex Filament, Robert Andrews

Mechanical Engineering Undergraduate Honors Theses

This paper details an investigation into methods and designs of 3D printing a microfluidic system capable of droplet emulsion using NinjaFlex filament. The specific field in which this paper’s experiment is rooted is dubbed “BioMEMS,” short for bio microelectromechanical systems. One prominent research area in BioMEMS is developing a “lab on a chip.” Essentially, the goal is to miniaturize common lab processes to the micro scale, rendering it possible to include these processes in a small chip. Reducing necessary sample sizes, shortening the reaction times of lab processes, and increasing mobility of lab processes can all be realized through ...


Placenta‐On‐A‐Chip: In Vitro Study Of Caffeine Transport Across Placental Barrier Using Liquid Chromatography Mass Spectrometry, Rajeendra L. Pemathilaka, Jeremy D. Caplin, Saurabh S. Aykar, Reza Montazami, Nicole N. Hashemi Mar 2019

Placenta‐On‐A‐Chip: In Vitro Study Of Caffeine Transport Across Placental Barrier Using Liquid Chromatography Mass Spectrometry, Rajeendra L. Pemathilaka, Jeremy D. Caplin, Saurabh S. Aykar, Reza Montazami, Nicole N. Hashemi

Mechanical Engineering Publications

Due to the particular structure and functionality of the placenta, most current human placenta drug testing methods are limited to animal models, conventional cell testing, and cohort/controlled testing. Previous studies have produced inconsistent results due to physiological differences between humans and animals and limited availability of human and/or animal models for controlled testing. To overcome these challenges, a placenta‐on‐a‐chip system is developed for studying the exchange of substances to and from the placenta. Caffeine transport across the placental barrier is studied because caffeine is a xenobiotic widely consumed on a daily basis. Since a fetus ...


Development Of Microdialysis Probes In Series Approach Toward Eliminating Microdialysis Sampling Calibration: Miniaturization Into A Pdms Microfluidic Device, Randy Espinal Cabrera May 2018

Development Of Microdialysis Probes In Series Approach Toward Eliminating Microdialysis Sampling Calibration: Miniaturization Into A Pdms Microfluidic Device, Randy Espinal Cabrera

Theses and Dissertations

A new microdialysis sampling method and microfluidic device were developed in vitro. The method consisted of using up to four microdialysis sampling probes connected in series to evaluate the relative recovery (RR) of different model solutes methyl orange, fluorescein isothiocyanate (FITC)-dextran average mol. wt. 4,000 (FITC-4), FITC-10, FITC-20, and FITC-40. Different flow rates (0.8, 1.0, and 1.5 µL/min) were used to compare experimentally observed relative recoveries with theoretical estimations. With increasing the number of probes in series, the relative recovery increases and ~100% (99.7% ± 0.9%) relative recovery for methyl orange was obtained ...


Microfluidic Technology And Application In Urinal Analysis, Jiwen Xiang Feb 2018

Microfluidic Technology And Application In Urinal Analysis, Jiwen Xiang

LSU Doctoral Dissertations

Microfluidic technology offers numerous advantages in minimizing and integrating the traditional assays. However, the lack of efficient control components of the microfluidic systems has been hindering the widely commercialization of the technology. The research work in this dissertation focused on the development of effective control components for microfluidic applications.

A linear peristaltic pump was firstly designed, fabricated, and tested for conventional microfluidics by synchronously compressing the microfluidic channel with a miniature cam-follower system in Chapter 2. The miniature cam-follower system and microfluidic chip was prototyped using three-dimensional (3D) printing technology and soft lithography technology. Results from experimental test showed that ...


Electric-Field Assisted Manipulation And Self-Assembly Of Particle Suspensions, Edison Chijioke Amah Jan 2018

Electric-Field Assisted Manipulation And Self-Assembly Of Particle Suspensions, Edison Chijioke Amah

Dissertations

No abstract provided.


Numerical Modeling Of Capillary-Driven Flow In Open Microchannels: An Implication Of Optimized Wicking Fabric Design, Mehrad Gholizadeh Ansari Jan 2018

Numerical Modeling Of Capillary-Driven Flow In Open Microchannels: An Implication Of Optimized Wicking Fabric Design, Mehrad Gholizadeh Ansari

Masters Theses

"The use of microfluidics to transfer fluids without applying any exterior energy source is a promising technology in different fields of science and engineering due to their compactness, simplicity and cost-effective design. In geotechnical engineering, to increase the soil's strength, hydrophilic wicking fibers as type of microfluidics have been employed to transport and drain water out of soil spontaneously by taking advantage of natural capillary force without using any pumps or other auxiliary devices. The objective of this study is to understand the scientific mechanisms of the capability for wicking fiber to drain both gravity and capillary water out ...


Improving Sensitivity Of Electrochemical Sensors With Convective Transport In Free-Standing, Carbon Nanotube Structures, Benjamin J. Brownlee, Kevin M. Marr, Jonathan C. Claussen, Brian D. Iverson Jun 2017

Improving Sensitivity Of Electrochemical Sensors With Convective Transport In Free-Standing, Carbon Nanotube Structures, Benjamin J. Brownlee, Kevin M. Marr, Jonathan C. Claussen, Brian D. Iverson

Jonathan C. Claussen

High-aspect-ratio, porous membrane of vertically-aligned carbon nanotubes (CNTs) were developed through a templated microfabrication approach for electrochemical sensing. Nanostructured platinum (Pt) catalyst was deposited onto the CNTs with a facile, electroless deposition method, resulting in a Pt-nanowire-coated, CNT sensor (PN-CNT). Convection mass transfer enhancement was shown to improve PN-CNT sensor performance in the non-enzymatic, amperometric sensing of hydrogen peroxide (H2O2). In particular, convective enhancement was achieved through the use of high surface area to fluid volume structures and concentration boundary layer confinement in a channel. Stir speed and sensor orientation especially influenced the measured current in stirred environments for sensors ...


Computational Methods And Software For The Design Of Inertial Microfluidic Flow Sculpting Devices, Daniel James Stoecklein Jan 2017

Computational Methods And Software For The Design Of Inertial Microfluidic Flow Sculpting Devices, Daniel James Stoecklein

Graduate Theses and Dissertations

The ability to sculpt inertially flowing fluid via bluff body obstacles has enormous promise for applications in bioengineering, chemistry, and manufacturing within microfluidic devices. However, the computational difficulty inherent to full scale 3-dimensional fluid flow simulations makes designing and optimizing such systems tedious, costly, and generally tasked to computational experts with access to high performance resources. The goal of this work is to construct efficient models for the design of inertial microfluidic flow sculpting devices, and implement these models in freely available, user-friendly software for the broader microfluidics community. Two software packages were developed to accomplish this: "uFlow" and "FlowSculpt ...


Manufacturing Microfluidic Flow Focusing Devices For Stimuli Responsive Alginate Microsphere Generation And Cell Encapsulation, Michael A. Karasinski Jan 2017

Manufacturing Microfluidic Flow Focusing Devices For Stimuli Responsive Alginate Microsphere Generation And Cell Encapsulation, Michael A. Karasinski

Graduate College Dissertations and Theses

In this paper a novel stimuli responsive hydrogel material, methacrylated sodium alginate beta-cyclodextrin (Alg-MA-β-CD), was used in combination with a microfluidic device to create microspheres. Currently there is no reliable method for fabricating homogeneous stimuli-responsive microspheres, in-house microfluidic devices are not reliable in manufacture quality or long-term use. Alginate hydrogels have many attractive characteristics for bioengineering applications and are commonly used to mimic the features and properties of the extracellular matrix (ECM). Human mesenchymal stem cells (hMSCs) are of top interest to tissue engineers. hMSCs are widely available and can be harvested and cultured directly out of human bone marrow ...


Precise Flow-Control Using Photo-Actuated Hydrogel Valves And Pid-Controlled Led Actuation, Colm Delaney, Simon Coleman, Jeff Whyte, Nigel Kent, Dermot Diamond Jan 2017

Precise Flow-Control Using Photo-Actuated Hydrogel Valves And Pid-Controlled Led Actuation, Colm Delaney, Simon Coleman, Jeff Whyte, Nigel Kent, Dermot Diamond

Articles

Herein we demonstrate remarkable control of flow within fluidic channels using photo-actuated hydrogel valves. By polymerizing the valves in situ it has been possible to create highly reproducible valves. Through the use of an LED platform and a PID algorithm we have generated extremely accurate flow control and created prototype devices to document their potential application within the microfluidics field.


Improving Sensitivity Of Electrochemical Sensors With Convective Transport In Free-Standing, Carbon Nanotube Structures, Benjamin J. Brownlee, Kevin M. Marr, Jonathan C. Claussen, Brian D. Iverson Jan 2017

Improving Sensitivity Of Electrochemical Sensors With Convective Transport In Free-Standing, Carbon Nanotube Structures, Benjamin J. Brownlee, Kevin M. Marr, Jonathan C. Claussen, Brian D. Iverson

Faculty Publications

High-aspect-ratio, porous membrane of vertically-aligned carbon nanotubes (CNTs) were developed through a templated microfabrication approach for electrochemical sensing. Nanostructured platinum (Pt) catalyst was deposited onto the CNTs with a facile, electroless deposition method, resulting in a Pt-nanowire-coated, CNT sensor (PN-CNT). Convection mass transfer enhancement was shown to improve PN-CNT sensor performance in the non-enzymatic, amperometric sensing of hydrogen peroxide (H2O2). In particular, convective enhancement was achieved through the use of high surface area to fluid volume structures and concentration boundary layer confinement in a channel. Stir speed and sensor orientation especially influenced the measured current in stirred ...


Digital-Lithographic Fabrication Of Unconventional 3d Microstructures, Ran He Jan 2017

Digital-Lithographic Fabrication Of Unconventional 3d Microstructures, Ran He

Theses and Dissertations

Developing advanced microfabrication technologies have been regarded as an important direction since many opportunities in technological innovations depend on the ability to fabricate novel structures in microscale. Commercially, high-throughput devices fabricated by cost-effective and efficient techniques that are suitable for mass production are highly desired. Scientifically, the ability to generate unconventional microstructures for improving the design and control experiments has attracted great interest of scientists. This dissertation presents five innovative techniques based on digital-lithographic fabrication to generate unconventional structures as better solutions in various applications. The techniques were firstly developed to advance the microfluidic areas, and then extended to 3D ...


Concurrent Detection And Isolation Of Cellular And Molecular Biomarkers, Wanfeng Huang Dec 2016

Concurrent Detection And Isolation Of Cellular And Molecular Biomarkers, Wanfeng Huang

Open Access Dissertations

Detection of cancer markers such as protein biomolecules and cancer cells in bodily fluids is of great importance in early diagnosis, prognosis as well as evaluation of therapy efficacy. Numerous devices have been developed for detecting either cellular or molecular targets, however there has not yet been a system that can simultaneously detect both cellular and molecular targets effectively. Molecule and cell-based assays are important because each type of target can tell a different story about the state of the disease and the two types of information can potentially be combined and/or compared for more accurate biological or clinical ...


Fundamental Studies Of Electrochemical Reactions And Microfluidics In Proton Exchange Membrane Electrolyzer Cells, Jingke Mo Dec 2016

Fundamental Studies Of Electrochemical Reactions And Microfluidics In Proton Exchange Membrane Electrolyzer Cells, Jingke Mo

Doctoral Dissertations

In electrochemical energy devices, including fuel cells, electrolyzers and batteries, the electrochemical reactions occur only on triple phase boundaries (TPBs). The boundaries provide the conductors for electros and protons, the catalysts for electrochemical reactions and the effective pathways for transport of reactants and products. The interfaces have a critical impact on the overall performance and cost of the devices in which they are incorporated, and therefore could be a key feature to optimize in order to turn a prototype into a commercially viable product. For electrolysis of water, proton exchange membrane electrolyzer cells (PEMECs) have several advantages compared to other ...


Pore Scale Transport Of Miscible And Immiscible Fluids In Porous Media, Tolulope O. Odimayomi, Arezoo M. Ardekani Aug 2016

Pore Scale Transport Of Miscible And Immiscible Fluids In Porous Media, Tolulope O. Odimayomi, Arezoo M. Ardekani

The Summer Undergraduate Research Fellowship (SURF) Symposium

The separation of harmful or valuable substances entrapped in porous media has applications in processes such as enhanced oil recovery, diffusion in tissue, and aquifer remediation. In this study the motion and removal rate of immiscible and miscible solutions have been analyzed to gain understanding of solvent effectiveness as it is diluted due to diffusion or mixing within porous materials. The extraction of oil using water, a surfactant solution of 4% CTAB in water, and a foam produced form the surfactant solution is observed using two dimensional flows between parallel slides containing cylindrical obstacles. The fluid motion is visualized. The ...


Movement And Distribution Of Bacteria Near Surfaces, Daniel A. Quinkert, Adib Ahmadzadegan, Arezoo M. Ardekani Aug 2016

Movement And Distribution Of Bacteria Near Surfaces, Daniel A. Quinkert, Adib Ahmadzadegan, Arezoo M. Ardekani

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bacteria are found everywhere in nature, including within human/animal bodies, biomedical devices, industrial equipment, oceans and lakes. They can be found in planktonic state within a bulk liquid phase or attached to surfaces with the potential to form biofilms. In this study we are interested in the movement and distribution of bacteria near surfaces. The concentrations and fluid interactions of bacteria were characterized at various distances from a surface. Psuedomonas putida F1 was observed in a suspension near a surface. Bacteria movements were visualized with an inverted microscope at 40x magnification. P. putida F1 exhibited greater density in close ...


Analysis Of Shock-Plugs In Quasi-One-Dimensional Compressible Flow, Matthew Alexander Thompson May 2016

Analysis Of Shock-Plugs In Quasi-One-Dimensional Compressible Flow, Matthew Alexander Thompson

Graduate Theses - Mechanical Engineering

At small length scales, such as in micro-nozzles, the assumption that a shock wave is infinitesimally thin breaks-down due to the thickness of the shock being non-negligible compared to the dimensions of the nozzle. In this thesis, shock waves of finite thickness, or “shock-plugs,” are modeled using the same methods and assumptions as a standard shock wave analysis. Due to the finite thickness of shock-plugs, however, two additional parameters are required in order to account for the differing inlet and exit areas, as well as the pressure on the side walls of the channel. A “typical” micro-nozzle with appropriate dimensions ...


Leidenfrost Energy Barriers, James Peck, Anton Hassebrook, Craig Zuhlke, Troy P. Anderson, Dennis R. Alexander, George Gogos, Sidy Ndao Apr 2016

Leidenfrost Energy Barriers, James Peck, Anton Hassebrook, Craig Zuhlke, Troy P. Anderson, Dennis R. Alexander, George Gogos, Sidy Ndao

UCARE Research Products

In this work, an “Energy Barrier” was created to control the motion of Leidenfrost droplets. This barrier was created by functionalizing a portion of a mirror-polished stainless steel 304 surface with Femtosecond Laser Surface Processing (FLSP). FLSP results in superhydrophilic, hierarchical, micro- and nanostructures which are highly wetting and thus have an increased Leidenfrost temperature. Water droplets in the film boiling state were deposited, and propelled by gravity towards the Energy Barrier interface. Room temperature droplets were deposited over a range of surface temperatures beginning with the Leidenfrost temperature of mirror-polished stainless steel 304 and culminating at the Leidenfrost temperature ...


Microfluidic Fiber Fabrication And Its Application In Neural Tissue Engineering, Farrokh Sharifi Jan 2016

Microfluidic Fiber Fabrication And Its Application In Neural Tissue Engineering, Farrokh Sharifi

Graduate Theses and Dissertations

Microfibers are becoming increasingly important for biomedical applications such as tissue engineering, drug delivery, and cell encapsulation. In this study, a microfluidic approach was used to fabricate biocompatible and biodegradable polymeric fibers. Chapter one gives an overview of the common microfiber fabrication methods followed by their advantages and disadvantages. Then, it focuses on the microfluidic platform and provides more information about different solidification strategies applied to fabricate fibers in this method. This chapter reviews some studies, which were recently published in this area as well.

Chapter two discusses using the microfluidic approach to fabricate continuous Polyvinyl alcohol (PVA) microfibers. It ...


Utilizing Microfluidic Technology To Replicate Placental Functions In A Drug Testing Model, Jeremy D. Caplin Jan 2016

Utilizing Microfluidic Technology To Replicate Placental Functions In A Drug Testing Model, Jeremy D. Caplin

Graduate Theses and Dissertations

In this experiment, a 3D microfluidic chip is designed and fabricated to replicate the function of the placenta. This sort of device has the potential to overtake current in vitro methods and become a physiologically relevant alternative to animal testing for the purpose of drug testing and toxicology.

First, PDMS layers were constructed with microchannels using a soft lithography method. These layers come together to “sandwich” a membrane coated with collagen. Once sealed, the physiologically appropriate cells are grown to represent the nutrient/waste transfer of the placenta. Human Umbilical Vein Endothelial Cells (HUVEC) were grown on one side of ...


Fiber Based Approaches As Medicine Delivery Systems, Farrokh Sharifi, Avinash C. Sooriyarachchi, Hayriye Altural, Reza Montazami, Marissa Nichole Rylander, Nicole Nastaran Hashemi Jan 2016

Fiber Based Approaches As Medicine Delivery Systems, Farrokh Sharifi, Avinash C. Sooriyarachchi, Hayriye Altural, Reza Montazami, Marissa Nichole Rylander, Nicole Nastaran Hashemi

Mechanical Engineering Publications

The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro- and nanofibers for this purpose. The reasons for this growing interest include these materials’ high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning ...


Analysis Of Capillary Flow In Interior Corners : Perturbed Power Law Similarity Solutions, Joshua Thomas Mccraney Dec 2015

Analysis Of Capillary Flow In Interior Corners : Perturbed Power Law Similarity Solutions, Joshua Thomas Mccraney

Dissertations and Theses

The design of fluid management systems requires accurate models for fluid transport. In the low gravity environment of space, gravity no longer dominates fluid displacement; instead capillary forces often govern flow. This thesis considers the redistribution of fluid along an interior corner. Following a rapid reduction of gravity, fluid advances along the corner measured by the column length z = L(t), which is governed by a nonlinear partial differential equation with dynamical boundary conditions. Three flow types are examined: capillary rise, spreading drop, and tapered corner. The spreading drop regime is shown to exhibit column length growth L ~ t2 ...


Design, Fabrication, And Testing Of A 3d Printer Based Microfluidic System, Carlton A. Mcmullen Dec 2015

Design, Fabrication, And Testing Of A 3d Printer Based Microfluidic System, Carlton A. Mcmullen

Theses and Dissertations

A pneumatically actuated PDMS based microfluidic devices were designed and fabricated by soft-lithography. Two types of molds were fabricated out of different material for this experiment. The first mold, (device 1), was fabricated from a sheet of Polymethyl methacrylate (PMMA) material, similar to Plexiglas. The device features were micro-engraved onto the face of the material. The second mold, (device 2), was fabricated from the use of fused deposition modeling (FDM) 3D printing. The pumping efficiency of the PDMS devices was analyzed through the characterization of the micro-pumps flowrate with respect to the pumps driving pressure and the actuation frequency. Tested ...


Microfluidic Organ‐On‐A‐Chip Technology For Advancement Of Drug Development And Toxicology, Jeremy D. Caplin, Norma G. Granados, Myra R. James, Reza Montazami, Nicole Nastaran Hashemi Jul 2015

Microfluidic Organ‐On‐A‐Chip Technology For Advancement Of Drug Development And Toxicology, Jeremy D. Caplin, Norma G. Granados, Myra R. James, Reza Montazami, Nicole Nastaran Hashemi

Mechanical Engineering Publications

In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of “organ‐on‐a‐chip” systems, researchers have proposed various methods on various organ‐on‐a‐chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ‐on‐a ...


A Microfluidic Mixer Utilizing Electrokinetic Relay Switching And Asymmetric Flow Geometries, Yiou Wang, Jiang Zhe, Prashanta Dutta, Benjamin Chung Apr 2015

A Microfluidic Mixer Utilizing Electrokinetic Relay Switching And Asymmetric Flow Geometries, Yiou Wang, Jiang Zhe, Prashanta Dutta, Benjamin Chung

Dr. Jiang Zhe

No abstract provided.


Multi-Pixel Photon Counters For Optofluidic Characterization Of Particles And Microalgae, Pouya Asrar, Marta Sucur, Nicole N. Hashemi Jan 2015

Multi-Pixel Photon Counters For Optofluidic Characterization Of Particles And Microalgae, Pouya Asrar, Marta Sucur, Nicole N. Hashemi

Mechanical Engineering Publications

We have developed an optofluidic biosensor to study microscale particles and different species of microalgae. The system is comprised of a microchannel with a set of chevron-shaped grooves. The chevrons allows for hydrodynamic focusing of the core stream in the center using a sheath fluid. The device is equipped with a new generation of highly sensitive photodetectors, multi-pixel photon counter (MPPC), with high gain values and an extremely small footprint. Two different sizes of high intensity fluorescent microspheres and three different species of algae (Chlamydomonas reinhardtii strain 21 gr, Chlamydomonas suppressor, and Chlorella sorokiniana) were studied. The forward scattering emissions ...


Numerical Studies Of Liquid-Liquid Segmented Flows In Square Microchannels Using A Front-Tracking Algorithm, Eamonn Daire Walker Jan 2015

Numerical Studies Of Liquid-Liquid Segmented Flows In Square Microchannels Using A Front-Tracking Algorithm, Eamonn Daire Walker

LSU Doctoral Dissertations

Liquid-liquid segmented flows in a square microchannel are investigated numerically using a hybrid front-tracking/front-capturing method. The code is found to be well-adapted to a large range of flow parameters, but droplet flows are limited by poor accuracy at Laplace number above 100 – 1000 and plug flows are limited by the code’s current inability to adequately model the flow in thin films at low capillary numbers. A Schwarz-Aitken acceleration technique is investigated as a means to reduce computation time, but is found not to be advantageous compared to the parallel multigrid formulation of the code. Numerical simulations are divided ...


Effect Of Junction Geometry On Monodispersed Microdroplet Generation In Microfluidic Aqueous Two-Phase Systems, Young Gyu Nam Aug 2014

Effect Of Junction Geometry On Monodispersed Microdroplet Generation In Microfluidic Aqueous Two-Phase Systems, Young Gyu Nam

Theses and Dissertations

Aqueous two-phase system (ATPS) consists of two immiscible water-based solutions of polymers, which can form phase partitioning. Dextran and polyethylene glycol I used in this thesis is the one of common components of aqueous two-phase system give a reliable and incompatible environment for purification of biomedical products and cellular macromolecules. Recently, ATPS have received increasing attention as a separation method in microfluidic device due to the advantages of biocompatibility, unlimited combination, and low interfacial tension. Hence, it became an important to discover researches related to ATPS microfluidic device.

Microdroplets produced in microfluidic device are a largely interesting phenomenon for various ...


Electrokinetic Particle Manipulations In Spiral Microchannels, John Dubose May 2014

Electrokinetic Particle Manipulations In Spiral Microchannels, John Dubose

All Theses

Recent developments in the field of microfluidics have created a multitude of new useful techniques for practical particle and cellular assays. Among them is the use of dielectrophoretic forces in 'lab-on-a-chip' devices. This sub-domain of electrokinetic flow is particularly popular due to its advantages in simplicity and versatility. This thesis makes use of dielectrophoretic particle manipulations in three distinct spiral microchannels. In the first of these experiments, we demonstrate the utility of a novel single-spiral curved microchannel with a single inlet reservoir and a single outlet reservoir for the continuous focusing and filtration of particles. The insulator-based negative-dielectrophoretic (repulsive) force ...


There Can Be Turbulence In Microfluidics At Low Reynolds Number, Guiren Wang, F. Yang, Wei Zhao Jan 2014

There Can Be Turbulence In Microfluidics At Low Reynolds Number, Guiren Wang, F. Yang, Wei Zhao

Faculty Publications

Turbulence is commonly viewed as a type of macroflow, where the Reynolds number (Re) has to be sufficiently high. In microfluidics, when Re is below or on the order of 1 and fast mixing is required, so far only chaotic flow has been reported to enhance mixing based on previous publications since turbulence is believed not to be possible to generate in such a low Re microflow. There is even a lack of velocimeter that can measure turbulence in microchannels. In this work, we report a direct observation of the existence of turbulence in microfluidics with Re on the order ...