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Full-Text Articles in Mechanical Engineering

High Performance Low Temperature Solid Oxide Fuel Cells With Novel Electrode Architecture, Yu Chen, Qian Liu, Zhibin Yang, Fanglin Chen, Minfang Han Dec 2012

High Performance Low Temperature Solid Oxide Fuel Cells With Novel Electrode Architecture, Yu Chen, Qian Liu, Zhibin Yang, Fanglin Chen, Minfang Han

Faculty Publications

In this study, we have fabricated high performance low temperature solid oxide fuel cells (LT-SOFCs) with both acicular anodes and cathodes with thin Gd-doped ceria (GDC) electrolyte film. The acicular Ni-Gd0.1Ce0.9O2−δ (Ni-GDC) anode was prepared using freeze drying tape casting, while the hierarchically porous cathode with nano-size Sm0.5Sr0.5CoO3 (SSC) particles covering an acicular GDC skeleton was prepared by a combination of freeze drying tape casting and self-rising approaches. The acicular electrodes with 5–200 μm pores/channels enhance mass transport, while SSC particles of about 50 nm in the cathode promote …


Energy Trapping Of Thickness-Shear And Thickness-Twist Modes In A Partially Electroded At-Cut Quartz Resonator, Huijing He, Guoquan Nie, Jinxi Liu, Jiashi Yang Dec 2012

Energy Trapping Of Thickness-Shear And Thickness-Twist Modes In A Partially Electroded At-Cut Quartz Resonator, Huijing He, Guoquan Nie, Jinxi Liu, Jiashi Yang

Department of Mechanical and Materials Engineering: Faculty Publications

The thickness-shear and thickness-twist vibrations of a finite and partially electroded AT-cut quartz resonator are investigated. The equations of anisotropic elasticity are used with the omission of the small elastic constant c56 . An analytical solution is obtained using Fourier series from which the free vibration resonant frequencies, mode shapes, and energy trapping are calculated and examined.


Sustainability For Die Manufacturing: Comparative Study Of Wedm And Milling, Matthew S. Kalus Dec 2012

Sustainability For Die Manufacturing: Comparative Study Of Wedm And Milling, Matthew S. Kalus

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Sustainability is more important in today's culture due to the increasing demand for a more eco-friendly society. Concentrations in minimizing and reducing environmental impacts, energy and natural resources have been forthcoming in industry. The tool, mold and die industries are the most well known industries that machine harder materials using mills and WEDM. The objective of this thesis was to compare the sustainability differences in both of these machines utilizing the accepted standards for evaluating the manufacturing process performance for sustainability. These standards include the evaluation of the process parameters, raw materials, power, tools and fluids which all contribute to …


A Study Of Hdpe In High Pressure Of Hydrogen Gas—Measurement Of Permeation Parameters And Fracture Criteria, Sompong Prachumchon Dec 2012

A Study Of Hdpe In High Pressure Of Hydrogen Gas—Measurement Of Permeation Parameters And Fracture Criteria, Sompong Prachumchon

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

The permeation parameters of hydrogen gas in high density polyethylene (HDPE) system are sought by comparison with a diffusion model. The method of Green’s functions is used to obtain solutions for the diffusion model. Permeation parameters are found from transient experimented data during two processes; pressurization followed by depressurization. The mechanical compression of HDPE during the pressurization process resulted in lower diffusivity coefficient values and higher solubility values. The results show that the diffusivity coefficient value in the pressurization process is 37% of that during the depressurization process. At the start of the depressurization process, a short-duration fast flow rate …


Predicting Vehicle Dynamics For Roadside Safety Using Multibody Systems Simulations, Brett D. Schlueter Nov 2012

Predicting Vehicle Dynamics For Roadside Safety Using Multibody Systems Simulations, Brett D. Schlueter

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Accurate means for predicting vehicle dynamics is required in the design and testing of roadside safety hardware. Past research has used finite element (FE) modeling to this end, but multibody systems (MBS) modeling may provide a more efficient way to solve these problems. MBS modeling using Adams/Car was investigated by first compiling an introduction to the program, then performing basic vehicle dynamics simulations using a supplied model. Next, a model of a 2270 kg pickup was created and validated against physical test data involving impact with a speed bump. Finally, pickup trajectories in 4H:1V and 6H:1V V-ditches were predicted for …


Atomistic Investigation Of Scratching-Induced Deformation Twinning In Nanocrystalline Cu, Junjie Zhang, Tao Sun, Yoganda Yan, Dong Shen, Xiaodong Li Oct 2012

Atomistic Investigation Of Scratching-Induced Deformation Twinning In Nanocrystalline Cu, Junjie Zhang, Tao Sun, Yoganda Yan, Dong Shen, Xiaodong Li

Faculty Publications

Deformation twinning is an important deformation mode of nanocrystalline metals. In current study, we investigate the scratching-induced deformation twinning in nanocrystallineCu by means of molecular dynamics simulations. The tribological behavior, the deformation mechanisms, the formation mechanism of deformation twins, and the grain size dependence of the propensity of deformation twinning are elucidated. Simulation results demonstrate that deformation twinning plays an important role in the plastic deformation of nanocrystallineCu under nanoscratching, in addition to dislocation activity and grain boundary-associated mechanism. The nucleation of initial twinning partial dislocations originates from the dissociation of lattice partial dislocations that emit from grain boundary triple …


Maximal Force Characteristics Of The Ca2+-Powered Actuator Of Vorticella Convallaria, Sangjin Ryu, Matthew J. Lang, Paul Matsudaira Sep 2012

Maximal Force Characteristics Of The Ca2+-Powered Actuator Of Vorticella Convallaria, Sangjin Ryu, Matthew J. Lang, Paul Matsudaira

Department of Mechanical and Materials Engineering: Faculty Publications

The millisecond stalk contraction of the sessile ciliate Vorticella convallaria is powered by energy from Ca2+ binding to generate contractile forces of ~10 nN. Its contractile organelle, the spasmoneme, generates higher contractile force under increased stall resistances. By applying viscous drag force to contracting V. convallaria in a microfluidic channel, we observed that the mechanical force and work of the spasmoneme depended on the stalk length, i.e., the maximum tension (150–350 nN) and work linearly depended on the stalk length (~2.5 nN and ~30 fJ per 1 mm of the stalk). This stalk-length dependency suggests that motor units of …


Shear-Horizontal Vibration Modes Of An Oblate Elliptical Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, John A. Kosinski Aug 2012

Shear-Horizontal Vibration Modes Of An Oblate Elliptical Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, John A. Kosinski

Department of Mechanical and Materials Engineering: Faculty Publications

We study shear-horizontal free vibrations of an elastic cylinder with an oblate elliptical cross section and a traction-free surface. Exact vibration modes and frequencies are obtained. The results show the existence of thickness-shear and thickness-twist modes. The energy-trapping behavior of these modes is examined. Trapped modes are found wherein the vibration energy is largely confined to the central portion of the cross section and little vibration energy is found at the edges. It is also shown that face-shear modes are not allowed in such a cylinder. The results are useful for the understanding of the energy trapping phenomenon in contoured …


Order-Disorder Transition Of Aragonite Nanoparticles In Nacre, Zaiwang Huang, Xiaodong Li Jul 2012

Order-Disorder Transition Of Aragonite Nanoparticles In Nacre, Zaiwang Huang, Xiaodong Li

Faculty Publications

Understanding nacre’s bottom-up biomineralization mechanism, particularly, how individual aragonite platelets are formed, has long remained elusive due to its crystallographic peculiarity and structural complexity. Here we report that crystallographic order-disorder transition can be triggered within individual aragonite platelets in pristine nacre by means of heat treatment and/or inelastic deformation, offering a unique opportunity to discriminate mysterious aragonite nanoparticles in transmission electron microscopy. Our findings unambiguously uncover why aragonite nanoparticles in pristine nacre have long been inaccessible under TEM observation, which is attributed to the monocrystal-polycrystal duality of the aragonite platelet. The underlying physical mechanism for why an individual aragonite platelet …


Nonlinear Mechanical Behavior Of The Human Common, External And Internal Carotid Arteries In Vivo, Alexey Kamenskiy, Yuris A. Dzenis, Jason N. Mactaggart, Thomas G. Lynch, Syed A. Jaffar Kazmi, Iraklis I. Pipinos Jul 2012

Nonlinear Mechanical Behavior Of The Human Common, External And Internal Carotid Arteries In Vivo, Alexey Kamenskiy, Yuris A. Dzenis, Jason N. Mactaggart, Thomas G. Lynch, Syed A. Jaffar Kazmi, Iraklis I. Pipinos

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction—The mechanical environment and properties of the carotid artery play an important role in the formation and progression of atherosclerosis in the carotid bifurcation. The purpose of this work was to measure and compare the range and variation of circumferential stress and tangent elastic moduli in the human common (CCA), external (ECA) and internal (ICA) carotid arteries over the cardiac cycle in vivo.

Methods—Measurements were performed in the surgically exposed proximal cervical CCA, distal ECA and distal ICA of normotensive patients (n = 16) undergoing carotid endarterectomy. All measurements were completed in vivo over the cardiac cycle …


Three-Dimensional Geometry Of The Human Carotid Artery, Alexey Kamenskiy, Jason N. Mactaggart, Iraklis I. Pipinos, Jai Bikhchandani, Yuris A. Dzenis Jun 2012

Three-Dimensional Geometry Of The Human Carotid Artery, Alexey Kamenskiy, Jason N. Mactaggart, Iraklis I. Pipinos, Jai Bikhchandani, Yuris A. Dzenis

Department of Mechanical and Materials Engineering: Faculty Publications

Accurate characterization of carotid artery geometry is vital to our understanding of the pathogenesis of atherosclerosis. Three-dimensional computer reconstructions based on medical imaging are now ubiquitous; however, mean carotid artery geometry has not yet been comprehensively characterized. The goal of this work was to build and study such geometry based on data from 16 male patients with severe carotid artery disease. Results of computerized tomography angiography were used to analyze the cross-sectional images implementing a semiautomated segmentation algorithm. Extracted data were used to reconstruct the mean three-dimensional geometry and to determine average values and variability of bifurcation and planarity angles, …


Identification Of A Maximum Guardrail Height For The Midwest Guardrail System Using Computer Simulation, Ramen D. Julin Jun 2012

Identification Of A Maximum Guardrail Height For The Midwest Guardrail System Using Computer Simulation, Ramen D. Julin

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

W-beam guardrails are by far the most common restraint system used along both local and major roadways. Traditionally, these restraint systems have been full-scale crash tested with a rail height ranging between 27 in. and 32 in. However, the maximum rail height which allows for safe performance of guardrails, especially in impacts involving small vehicles, has never been identified.

The main concern associated with an increase of the rail height is that small vehicles, because of their low profile, may have a tendency to lift the rail and penetrate the barrier. The objective of this project was to determine the …


Rehabilitation And Exercise Machine, Judith M. Burnfield, Yu Shu, Thad W. Buster, Carl Nelson May 2012

Rehabilitation And Exercise Machine, Judith M. Burnfield, Yu Shu, Thad W. Buster, Carl Nelson

Department of Mechanical and Materials Engineering: Faculty Publications

An improved rehabilitation and exercise machine is provided which allows a person with physical limitations, disabilities or chronic conditions to use the machine in order to rehabilitate their muscles, improve joint flexibility, and enhance cardiovascular fitness.


Model-Based Systems And Methods For Analyzing And Predicting Outcomes Of Vascular Interventions And Reconstructions, Yuris A. Dzenis, Alexey Kamenskiy, Iraklis I. Pipinos, Jason N. Mactaggart Apr 2012

Model-Based Systems And Methods For Analyzing And Predicting Outcomes Of Vascular Interventions And Reconstructions, Yuris A. Dzenis, Alexey Kamenskiy, Iraklis I. Pipinos, Jason N. Mactaggart

Department of Mechanical and Materials Engineering: Faculty Publications

Systems and methods for analyzing and predicting treatment outcomes of medical procedures such as vascular interventions and reconstructions are disclosed. An illustrative system for analyzing and predicting therapeutic outcomes of medical procedures comprises a relational database configured for classifying and storing patient specific input data for multiple patients, a fluid-solid interaction biomechanical model configured for performing a biomechanics simulation and generating biomechanics data, and a graphical user interface.


Water Main Break Rates In The Usa And Canada: A Comprehensive Study, April 2012, Steven Folkman Apr 2012

Water Main Break Rates In The Usa And Canada: A Comprehensive Study, April 2012, Steven Folkman

Mechanical and Aerospace Engineering Faculty Publications

Modern societies base their economic prosperity on a standard of living which includes a complex network of infrastructure, both above and below ground. Quality drinking water brought to the tap through elaborate underground distribution systems is a critical component to our public health and economic well-being. In the USA and Canada, it has been the hallmark of our industry and cooperation.

EVIDENCE OF DECLINE

Our water infrastructure is now in decline after decades of service. The signs of distress surface daily as water mains break, creating floods and sink holes. The loss of water service is more than an inconvenience, …


Effects Of Mismatched Electrodes On An At-Cut Quartz Resonator, Huijing He, Jinxi Liu, Jiashi Yang Feb 2012

Effects Of Mismatched Electrodes On An At-Cut Quartz Resonator, Huijing He, Jinxi Liu, Jiashi Yang

Department of Mechanical and Materials Engineering: Faculty Publications

We study thickness-shear and thickness-twist free vibrations of a finite AT-cut quartz resonator with mismatched electrodes. The equations of anisotropic elasticity are used with the omission of the small elastic constant c56. An analytical solution is obtained using Fourier series from which the resonant frequencies, mode shapes, and vibration confinement resulting from the electrode inertia are calculated and examined.


Techniques For Industrial Implementation Of Emerging Semantic Technologies, Jay T. Breindel Jan 2012

Techniques For Industrial Implementation Of Emerging Semantic Technologies, Jay T. Breindel

Masters Theses 1911 - February 2014

Techniques for the industrial implementation of emerging semantic technologies are presented in this research. Every new design, project, and procedure within a company generates a considerable amount of new information and important knowledge. Furthermore, a tremendous amount of legacy knowledge already exists within companies in electronic and non-electronic formats. All of this generated knowledge results in the need for tools and techniques to represent, structure, and reuse this knowledge. Researchers have spent considerable time and effort developing semantic knowledge management systems, with anticipation that these tools will address these knowledge management needs. However, little has been done to implement these …


Simulations Of Non-Contact Creep In Regimes Of Mixed Dominance, Maija Benitz Jan 2012

Simulations Of Non-Contact Creep In Regimes Of Mixed Dominance, Maija Benitz

Masters Theses 1911 - February 2014

Improvement of high temperature applications relies on the further development of ultra-high temperature materials (UHTMs). Higher performance and efficiency is driving the need for improvements in energy conversion and propulsion systems. Rocket nozzles, gas turbine engines and hypersonic aircraft depend on a better understanding of a material's performance at high temperatures. More specifically, the characterization of creep properties of high temperature materials is required. Conventional creep testing methods are limited to about 1700 degrees Celsius. Non-contact methods have been developed, which rotate spherical samples up to 33,000 rotations per second. A load is supplied by centripetal acceleration causing deformation of …


Viscoelastic Flow Through Contraction Geometries, Ashwin Karthik Sankaran Jan 2012

Viscoelastic Flow Through Contraction Geometries, Ashwin Karthik Sankaran

Masters Theses 1911 - February 2014

Contraction flow of viscoelastic fluids has been a benchmark problem in non-Newtonian fluid mechanics because it mimics flows occurring in a number of industrial applications. It is also of considerable interest to academia to gain fundamental understanding of factors that affect the evolution of vortices and a complete understanding of the dynamics for a simple polymeric fluid has not been achieved. In this two part study we investigate the effect of pre deformation of a Boger fluid in a contraction geometry and the flow of surfactants in a parallel contraction geometry.

Entry flow of a polymeric fluid results in the …


Vibration Reduction Of Offshore Wind Turbines Using Tuned Liquid Column Dampers, Colin Roderick Jan 2012

Vibration Reduction Of Offshore Wind Turbines Using Tuned Liquid Column Dampers, Colin Roderick

Masters Theses 1911 - February 2014

Offshore wind turbines (OWTs) are becoming an accepted method for generating electricity. The environmental conditions of offshore locations often impose high wind and wave forces on OWTs making them susceptible to intense loading and undesirable vibrations. One method to reduce system vibrations is through the use of structural control devices typically utilized in civil structures. Tuned liquid column dampers (TLCDs) show great promise in the application to OWTs due to their high performance and low cost. This thesis examines the use of TLCDs in OWTs.

Equations of motion for limited degree-of-freedom TLCD-turbine models are presented. A baseline analysis of each …


A Nonlinear Model For Wind-Induced Oscillations Of Trees, Lakshmi Narayanan Ramanujam Jan 2012

A Nonlinear Model For Wind-Induced Oscillations Of Trees, Lakshmi Narayanan Ramanujam

Masters Theses 1911 - February 2014

Ambient wind causes trees to oscillate. Wind-induced oscillations of trees constitute a fluid-structure interaction problem, which has been studied by many researchers from various points of view. However, there is yet a lot to be done. From an engineering point of view, the complex structure of trees, which are very different from man-made structures, as well as the highly nonlinear interaction between wind and tree, makes it a challenging task to predict the amplitude and frequency of the resulting oscillations. From a biological point of view, the influence of wind on photosynthesis as well as the growth and death of …


Physical Model Of The Feeding Strike Of The Mantis Shrimp, Suzanne M. Cox Jan 2012

Physical Model Of The Feeding Strike Of The Mantis Shrimp, Suzanne M. Cox

Masters Theses 1911 - February 2014

A physical model was built to study the properties of the feeding strike of the mantis shrimp that are responsible for drag reduction and cavitation control. The model had three goals: 1) The model was to be outfitted with a method to collect kinematic, force and cavitation data. 2) The velocity and acceleration profile of the model were to be predicted with a mathematical model of the mechanism. 3) The model was to match as many drag and cavitation sensitive properties of the mantis shrimp strike as feasible and have a means to control the rest. The first iteration of …


Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue Jan 2012

Nanotopographic Cell Culture Substrate: Polymer-Demixed Nanotextured Films Under Cell Culture Conditions, Jung Yul Lim, Christopher A. Siedlecki, Henry J. Donahue

Department of Mechanical and Materials Engineering: Faculty Publications

Modulating physical cell culture environments via nanoscale substrate topographic modification has recently been of significant interest in regenerative medicine. Many studies have utilized a polymer-demixing technique to produce nanotextured films and showed that cellular adhesion, proliferation, and differentiation could be regulated by the shape and scale of the polymer-demixed nanotopographies. However, little attention has been paid to the topographic fidelity of the polymer-demixed films when exposed to cell culture conditions. In this brief article, two polymer-demixing systems were employed to assess topographic changes in polymer-demixed films after fibronectin (FN) extracellular matrix protein adsorption and after incubation in phosphate-buffered saline at …


Usability Assessment Of Two Different Control Modes For The Master Console Of A Laparoscopic Surgical Robot, Xiaoli Zhang, Carl A. Nelson, Dmitry Oleynikov Jan 2012

Usability Assessment Of Two Different Control Modes For The Master Console Of A Laparoscopic Surgical Robot, Xiaoli Zhang, Carl A. Nelson, Dmitry Oleynikov

Department of Mechanical and Materials Engineering: Faculty Publications

The objective of this study is to evaluate potential interface control modes for a compact fourdegree- of-freedom (4-DOF) surgical robot. The goal is to improve robot usability by incorporating a sophisticated haptics-capable interface. Two control modes were developed using a commercially available haptic joystick: (1) a virtually point-constrained interface providing an analog for constrained laparoscopic motion (3-DOF rotation and 1-DOF translation), and (2) an unconstrained Cartesian input interface mapping more directly to the surgical tool tip motions. Subjects (n = 5) successfully performed tissue identification and manipulation tasks in an animal model in point-constrained and unconstrained control modes, respectively, with …


Tool Sequence Trends In Minimally Invasive Surgery: Statistical Analysis And Implications For Predictive Control Of Multifunction Instruments, Carl A. Nelson, Evan Luxon, Dmitry Oleynikov Jan 2012

Tool Sequence Trends In Minimally Invasive Surgery: Statistical Analysis And Implications For Predictive Control Of Multifunction Instruments, Carl A. Nelson, Evan Luxon, Dmitry Oleynikov

Department of Mechanical and Materials Engineering: Faculty Publications

This paper presents an analysis of 67 minimally invasive surgical procedures covering 11 different procedure types to determine patterns of tool use. A new graph-theoretic approach was taken to organize and analyze the data. Through grouping surgeries by type, trends of common tool changes were identified. Using the concept of signal/noise ratio, these trends were found to be statistically strong. The tool-use trends were used to generate tool placement patterns for modular (multi-tool, cartridge-type) surgical tool systems, and the same 67 surgeries were numerically simulated to determine the optimality of these tool arrangements. The results indicate that aggregated tool-use data …


Method For Increasing The Efficiency Of Organic Photovoltaic Cells, Jinsong Huang, Yongbo Yuan Jan 2012

Method For Increasing The Efficiency Of Organic Photovoltaic Cells, Jinsong Huang, Yongbo Yuan

Department of Mechanical and Materials Engineering: Faculty Publications

The present invention is directed to an organic photovoltaic cell that contains one or more dipole regions generally disposed between an organic active region and the electrodes and a process for producing such an organic photovoltaic cell.


Moisture Damage Characterization Of Warm-Mix Asphalt Mixtures Based On Laboratory-Field Evaluation, Yong-Rak Kim, Jun Zhang, Hoki Ban Jan 2012

Moisture Damage Characterization Of Warm-Mix Asphalt Mixtures Based On Laboratory-Field Evaluation, Yong-Rak Kim, Jun Zhang, Hoki Ban

Department of Mechanical and Materials Engineering: Faculty Publications

This study presents laboratory evaluation integrated with field performance to examine two widely used warm-mix asphalt (WMA) approaches—foaming and emulsion technology. For a more realistic evaluation of the WMA approaches, trial pavement sections of the WMA mixtures and their counterpart hot-mix asphalt (HMA) mixtures were implemented in Antelope County, Nebraska. Field-mixed loose mixtures collected at the time of paving were transported to the laboratories to conduct various experimental evaluations of the individual mixtures. Among the laboratory tests, three (two conventional and one newly attempted) were performed to characterize moisture damage potential which is the primary focus of this study. From …


Thickness-Shear And Thickness-Twist Modes In An Oblate Elliptical Ceramic Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, Yi-Hua Huang Jan 2012

Thickness-Shear And Thickness-Twist Modes In An Oblate Elliptical Ceramic Cylinder And Energy Trapping In Contoured Acoustic Wave Resonators, Huijing He, Jiashi Yang, Yi-Hua Huang

Department of Mechanical and Materials Engineering: Faculty Publications

We study shear-horizontal motions of a piezoelectric ceramic cylinder with an oblate elliptical cross section and axial poling. Exact thickness-shear and thickness-twist vibration modes are obtained. These modes show energy trapping, i.e., the vibration is mainly confined near the thick, central region and decays to almost nothing near the edges. The results are useful for the understanding and design of contoured piezoelectric resonators for strong energy trapping.


Macro And Microfluidic Flows For Skeletal Regenerative Medicine, Brandon D. Riehl, Jung Yul Lim Jan 2012

Macro And Microfluidic Flows For Skeletal Regenerative Medicine, Brandon D. Riehl, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

Fluid flow has a great potential as a cell stimulatory tool for skeletal regenerative medicine, because fluid flow-induced bone cell mechanotransduction in vivo plays a critical role in maintaining healthy bone homeostasis. Applications of fluid flow for skeletal regenerative medicine are reviewed at macro and microscale. Macroflow in two dimensions (2D), in which flow velocity varies along the normal direction to the flow, has explored molecular mechanisms of bone forming cell mechanotransduction responsible for flow-regulated differentiation, mineralized matrix deposition, and stem cell osteogenesis. Though 2D flow set-ups are useful for mechanistic studies due to easiness in in situ and post-flow …


Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams Jan 2012

Systems And Synthetic Biology Of The Vessel Wall, Jennifer Frueh, Nataly Maimari, Ying Lui, Zoltan Kis, Vikram Mehta, Negin Pormehr, Calum Grant, Emmanuel Chalkias, Mika Falck-Hansen, Sandra Bovens, Ryan M. Pedrigi, Taka Homma, Gianfillippo Coppola, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.