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Articles 1 - 7 of 7
Full-Text Articles in Mechanical Engineering
In Situ Preconcentration By Ac Electrokinetics For Rapid And Sensitive Nanoparticle Detection, Kai Yang
In Situ Preconcentration By Ac Electrokinetics For Rapid And Sensitive Nanoparticle Detection, Kai Yang
Doctoral Dissertations
Reducing cost and time is a major concern in clinical diagnostics. Current molecular diagnostics are multi-step processes that usually take at least several hours or even days to complete multiple reagents delivery, incubations and several washing processes. This highly labor-intensive work and lack of automation could result in reduced reliability and low efficiency. The Laboratory-on-a-chip (LOC), taking advantage of the merger and development of microfluidics and biosensor technology, has shown promise towards a solution for performing analytical tests in a self-contained and compact unit, enabling earlier and decentralized testing. However, challenges are to integrate the fluid regulatory elements on a …
Direct Current Electrokinetic Particle Transport In Micro/Nano-Fluidics, Ye Ai
Direct Current Electrokinetic Particle Transport In Micro/Nano-Fluidics, Ye Ai
Mechanical & Aerospace Engineering Theses & Dissertations
Electrokinetics has been widely used to propel and manipulate particles in micro/nano-fluidics. The first part of this dissertation focuses on numerical and experimental studies of direct current (DC) electrokinetic particle transport in microfluidics, with emphasis on dielectrophoretic (DEP) effect. Especially, the electrokinetic transports of spherical particles in a converging-diverging microchannel and an L-shaped microchannel, and cylindrical algal cells in a straight microchannel have been numerically and experimentally studied. The numerical predictions are in quantitative agreement with our own and other researchers' experimental results. It has been demonstrated that the DC DEP effect, neglected in existing numerical models, plays an important …
High Speed Continuous Thermal Curing Microfabrication System, Franklin Dibartolomeo
High Speed Continuous Thermal Curing Microfabrication System, Franklin Dibartolomeo
University of Kentucky Master's Theses
Rapid creation of devices with microscale features is a vital step in the commercialization of a wide variety of technologies, such as microfluidics, fuel cells and self-healing materials. The current standard for creating many of these microstructured devices utilizes the inexpensive, flexible material poly-dimethylsiloxane (PDMS) to replicate microstructured molds. This process is inexpensive and fast for small batches of devices, but lacks scalability and the ability to produce large surface-area materials. The novel fabrication process presented in this paper uses a cylindrical mold with microscale surface patterns to cure liquid PDMS prepolymer into continuous microstructured films. Results show that this …
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
ETD Archive
The DNA Medicine Institute (DMI) is currently developing a device to be used for blood analysis to satisfy the unique requirements of space medicine applications. A key component of that device is the micromixer, which will ensure mixing and dilution of reagents utilized for detection assays. As part of the device design process, the micromixer was modeled, and the mixing characteristics were analyzed and compared to experimental data. The experimental data was based on a top-view of the system and, lacking data throughout the fluid domain, could not provide the insight into the mixing process that modeling could readily provide. …
Streaming Potential Generated By A Pressure-Driven Flow Over Superhydrophobic Stripes, Hui Zhao
Streaming Potential Generated By A Pressure-Driven Flow Over Superhydrophobic Stripes, Hui Zhao
Mechanical Engineering Faculty Research
The streaming potential generated by a pressure-driven flow over a weakly charged slip-stick surface [the zeta potential of the surface is smaller than the thermal potential (25 mV)] with an arbitrary double layer thickness is theoretically studied by solving the Debye–Huckel equation and Stokes equation. A series solution of the streaming potential is derived. Approximate expressions for the streaming potential in the limits of thin double layers and thick double layers are also given in excellent agreement with the full solution. To understand the impact of the slip, the streaming potential is compared against that over a homogeneously charged smooth …
Quasi-Steady Capillarity-Driven Flows In Slender Containers With Interior Edges, Mark M. Weislogel, J. Alex Baker, Ryan M. Jenson
Quasi-Steady Capillarity-Driven Flows In Slender Containers With Interior Edges, Mark M. Weislogel, J. Alex Baker, Ryan M. Jenson
Mechanical and Materials Engineering Faculty Publications and Presentations
In the absence of significant body forces the passive manipulation of fluid interfacial flows is naturally achieved by control of the specific geometry and wetting properties of the system. Numerous 'microfluidic' systems on Earth and 'macrofluidic' systems aboard spacecraft routinely exploit such methods and the term ‘capillary fluidics’ is used to describe both length-scale limits. In this work a collection of analytic solutions is offered for passive and weakly forced flows where a bulk capillary liquid is slowly drained or supplied by a faster capillary flow along at least one interior edge of the container. The solutions are enabled by …
A Microfluidic Device For Impedance Spectroscopy, Ahmet Can Sabuncu
A Microfluidic Device For Impedance Spectroscopy, Ahmet Can Sabuncu
Mechanical & Aerospace Engineering Theses & Dissertations
Recently, microfluidics has become a versatile tool to investigate cellular biology and to build novel biomedical devices. Dielectric spectroscopy, on the other hand, allows non-invasive probing of biological cells. Information on the cell membrane, cytoplasm, and nucleus can be obtained by dielectric spectroscopy provided that appropriate tools are used in specific frequency ranges. This dissertation includes fabrication, characterization, and testing of a simple microfluidic device to measure cell dielectric properties. The dielectric measurements are performed on human T-cell leukemia (Jurkat), mouse melanoma (B16), mouse hepatoma (Hepa), and human costal chondrocyte cells. Dielectric measurements consist of measuring the complex impedance of …