Mechanical Engineering Commons^™

Pulmonary Fluid Dynamics And Aerosol Drug Delivery In The Upper Tracheobronchial Airways Under Mechanical Ventilation Conditions, Timothy Andrew Van Rhein

Masters Theses

"The effects of mechanical ventilation conditions on fluid flow and particle deposition were studied in a computer model of the human airways. The frequency with which aerosolized drugs are delivered to mechanically ventilated patients demonstrates the importance of understanding the effects that ventilation parameters have on particle deposition in the human airways. Past studies that modeled particle deposition in silico frequently used an idealized geometry with steady inlet conditions. With recent advancements in computational power and medical imaging capabilities, studies have begun to use more realistic geometries or unsteady inlet conditions that model normal breathing. This study focuses specifically on …