Mechanical Engineering Commons^™

Developing Nanopore Electromechanical Sensors With Transverse Electrodes For The Study Of Nanoparticles/Biomolecules, Mohammadsadegh Beheshti

LSU Doctoral Dissertations

This study concerns development of a technology of utilizing metallic nanowires for a sensing element in nanofluidic single molecular (nanoparticle) sensors formed in plastic substrates to detect the translocation of single molecules through the nanochannel. We aimed to develop nanofluidic single molecular sensors in plastic substrates due to their scalability towards high through and low cost manufacturing for point-of-care applications. Despite significant research efforts recently on the technologies and applications of nanowires, using individual nanowires as electric sensing element in nanofluidic bioanalytic devices has not been realized yet. This dissertation work tackles several technical challenges involved in this development, which …