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Articles 1 - 5 of 5
Full-Text Articles in Mechanical Engineering
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Dissertations and Theses
Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The …
Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien
Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien
Dissertations and Theses
In vitro tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D in vitro models allow the cells to grow and interact with their surroundings in all directions, thus better mimicking in vivo than their 2D counterparts. The objective of this thesis is to establish a 3D in vitro model that mimics the anatomical and functional complexity of the realistic cancer microenvironment for conveniently studying the transport coupling in porous tissue structures. We pack uniform-sized PEGDA-GelMA microgels in a microfluidic chip to …
Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar
Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar
Dissertations and Theses
Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It has been shown that the subarachnoid space (SAS) trabeculae play an important role in damping the effect of an impact, thus reducing the injuries. However, the influence of sulci parameters and the sulci trabeculae in TBI due to impact is unexplored. Studies have shown that inclusion of sulci in brain models …
Feasibility Analysis Of Estrification Systems With Entrainers, Kang Wook Lee
Feasibility Analysis Of Estrification Systems With Entrainers, Kang Wook Lee
Dissertations and Theses
(Ethyl Acetate) and IPA (Isopropyl Acetate) production systems are studied in terms of the feasibility analysis. It is not feasible to retrieve pure products by a simple reactive distillation for IPA production system because CCR (Critical Composition Region) covers the entire desired binary edge for IPA system. On the other hand, even though CCR does not cover the entire desired binary edge of the EA system completely, internal reflux ratio (IRR) analysis does not allow the production of the pure product via reactive distillation for EA production system. To overcome the restraints, external entrainers are utilized to take advantage of …
Investigation Of Blood Pressure Measurement Using A Hydraulic Occlusive Cuff, Kusha R. Bhattarai
Investigation Of Blood Pressure Measurement Using A Hydraulic Occlusive Cuff, Kusha R. Bhattarai
Dissertations and Theses
This thesis presents an improved oscillotonometric system for the measurement of human blood pressure. The study included:
1. The design of a hydraulic occlusive cuff,
2. The investigation of the wave forms taken from the blood pressure measurements, and
3. The design of a mechanism for the simulation of human blood pressure pulse.
In this study, an experimental system consisting of a rigid shell occlusive cuff, a constant volume displacement pump, a transducer, and a chart recorder was designed and used for data collection.