Mechanical Engineering Commons^™

Label-Free Mapping Of Near-Field Transport Properties Of Micro/Nano-Fluidic Phenomena Using Surface Plasmon Resonance (Spr) Reflectance Imaging, Iltai Kim

Doctoral Dissertations

My doctoral research has focused on the development of surface plasmon resonance (SPR) reflectance imaging technique to detect near-field transport properties such as concentration, temperature, and salinity in micro/nano fluidic phenomena in label-free, real-time, and full-field manner. A label-free visualization technique based on surface plasmon resonance (SPR) reflectance sensing is presented for real-time and full-field mapping of microscale concentration and temperature fields. The key idea is that the SPR reflectance sensitivity varies with the refractive index of the near-wall region of the test mixture fluid. The Fresnel equation, based on Kretschmann’s theory, correlates the SPR reflectance with the refractive index …

Development And Implementation Of Mathematical Modeling, Vibration And Acoustic Emission Technique To Correlate In Vivo Kinematics, Kinetics And Sound In Total Hip Arthroplasty With Different Bearing Surfaces, Diana Andreeva Glaser

Doctoral Dissertations

The evaluation of Total Hip Arthroplasty (THA) outcome is difficult and invasive methods are often applied. Fluoroscopy has been used as an in vivo diagnostic technique to determine separation which may lead to vibration propagation and audible interactions. The objective of this study was to develop a new, non-invasive technique of digitally capturing vibration and sound emissions at the hip joint interface and to correlate those with the hip kinematics derived from fluoroscopy. Additionally, an examination of the role of hip mechanics on walking performance in THA subjects of various bearings surfaces was performed.

In vivo kinematics, kinetics, corresponding vibration …

Characterization Of Dynamic Response Of Afm Cantilevers For Microscale Thermofluidic And Biophysical Sensors, Seonghwan Kim

Doctoral Dissertations

My doctoral research has focused on the characterization of dynamic response of atomic force microscope (AFM) cantilevers for thermofluidic and biophysical sensors, a novel scanning thermal microscopy technique development using a tipless microcantilever to investigate micro/nanoscale transport properties in liquid, and the characterization of the surface nanomechanical properties of biocompatible polyelectrolyte hydrogels with AFM for biomedical applications.

The temperature effects on Sader‟s viscous model for multilayered microcantilevers immersed in an aqueous medium were experimentally verified as a preliminary work. Next, temperature dependence of the near-wall oscillation of microcantilevers submerged in an aqueous medium was investigated to explore the possibility of …

From Nearfield Nanoparticle Tracking To Intracellular Vesicle Tracking, Charles H. Margraves

Doctoral Dissertations

The initial goal of this research was to measure the hindered Brownian motion of nanoparticles (100 nm to 500 nm in radii), in varying salinities of water, in order to compare the normal and tangential motion with existing theory. Using techniques developed from this work, brain cancer cells containing vesicles loaded with Nonsteroidal anti-inflammatory drug-Activated Gene-1 (NAG-1), tagged with a Green Fluorescent Protein (GFP), were examined to see what effect the glass cover slip played in hindering their motion.

Several microscopy techniques have been used in this work including Total Internal Reflection Fluorescent Microscopy (TIRFM) and Differential Interference Reflection Microscopy …

Bandwidth On Demand For Laser Communications Satellites, Alexander M. Melin

Doctoral Dissertations

Narrow beamwidth satellites such as laser communication or imaging satellites present a unique problem in control and scheduling. The narrow beamwidth limits the sources of information avail- able to the satellite. This is especially true for laser communication satellites who can only point the laser at one user at a time. For the most part, this restricts the use of laser communications satellites to fixed connections or dedicated temporary connections. However, some classes of users can benefit from the speed and security of the lasercom connection. For example, a Globalhawk unmanned aerial vehicle with time sensitive battlefield imaging would be …

Nonlinear Unsteady Combustion Of A Solid Propellant, Mark William Olles

Doctoral Dissertations

A nonlinear burning model is developed, valid across a wide range of frequencies, to allow for the incorporation of an admittance function into a nonlinear combustion instability (CI) framework. This is accomplished by extending two existing models to incorporate the effects of nonlinearity, the QSHOD ( Α Β ) model as described by Culick in his 1968 review paper and the 1973 T’ien model. The classical QSHOD model is marred by major limitations due to the simplifications and assumptions made. The most evident is the exclusion of the unsteady gas phase eliminating the high frequency response. The less recognized T’ien …