Open Access. Powered by Scholars. Published by Universities.®

Mechanical Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Old Dominion University

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 1 - 30 of 368

Full-Text Articles in Mechanical Engineering

Loading Orientation Dependence On The Compressive Response Of Ice-Templated Ceramic-Polymer Composites, Sashanka Akurati, Justine Marin, Dipankar Ghosh Apr 2020

Loading Orientation Dependence On The Compressive Response Of Ice-Templated Ceramic-Polymer Composites, Sashanka Akurati, Justine Marin, Dipankar Ghosh

College of Engineering & Technology (Batten) Posters

Natural materials are made from weak constituents, yet exhibit an excellent synergy of high stiffness, strength, and damage-tolerance. They consist of alternate layers of the hard and soft phases with a complex hierarchical structural organization. The ice-templating technique provides an approach to fabricate multilayered architectures for engineering applications. In this technique, an aqueous ceramic suspension is solidified unidirectionally leading to phase separation into alternating layers of ice-crystals and ceramic particles. Ice-crystals are sublimated by freeze-drying process and resultant ceramic foams are sintered to impart strength. The fabricated sintered ceramic foams contain alternate layers of oriented ceramic lamella walls and pores ...


A Study Of The Aeroacoustics Of Swept Propellers For Small Unmanned Aerial Vehicles, Arthur David Wiedemann Apr 2020

A Study Of The Aeroacoustics Of Swept Propellers For Small Unmanned Aerial Vehicles, Arthur David Wiedemann

Mechanical & Aerospace Engineering Theses & Dissertations

In recent years, small unmanned aerial vehicles (UAVs) have increased in availability and use in both public and commercial sectors. This increased use of small UAVs or “drones” has the unfortunate consequence of introducing excessive noise into communities where they operate. Implementation of noise reduction methods is necessary if we wish to see expanded use of drones in public areas. With electric propulsion, the primary source of noise is the rotor/propeller used in contemporary multi-rotor configurations. In this thesis, the aerodynamics and acoustic behavior of various swept propellers is examined with computational and experimental methods.

A family of propeller ...


Compaction And Residual Stress Modeling In Composite Manufactured With Automated Fiber Placement, Von Clyde Jamora Apr 2020

Compaction And Residual Stress Modeling In Composite Manufactured With Automated Fiber Placement, Von Clyde Jamora

Mechanical & Aerospace Engineering Theses & Dissertations

Automated fiber placement is a state-of-the-art manufacturing process that allows for complex layup patterns and can quickly place, cut, and restart composite tows. However, with this type of manufacturing process layup defects are inevitable, and manufacturing defects propagate after curing. Process modeling is the considered approach for exploring the defect prediction. Two different but related works were conducted, which are the thermochemical and hyperelastic model and the residual deformation model. For the model before cooling, a hyperelastic model and a thermo-chemical were made to simulate the compaction and heat transfer. Temperature dependent properties that are a function of degree of ...


Role Of Anisometric Particles In Ice-Templated Porous Ceramic Structure And Mechanical Properties, Mahesh Banda Apr 2020

Role Of Anisometric Particles In Ice-Templated Porous Ceramic Structure And Mechanical Properties, Mahesh Banda

Mechanical & Aerospace Engineering Theses & Dissertations

Open-cell macroporous ceramics have a significant impact on advancing various engineering endeavors such as bone-tissue engineering, lithium-ion batteries, filtration, thermal insulation, impact protection, etc. While pore orientation in conventional open-cell foams is random, in recent years, significant interest has grown in utilizing directionally porous ceramics in these applications to enhance performance. Ice-templating has emerged as a versatile technique that can synthesize directionally macroporous ceramics with low pore tortuosity. Although the fabrication is relatively straightforward, the challenge is that there are numerous variables associated with this technique, which can have significant effects on the final structure and macroscopic properties. As a ...


Thermal Contact Resistance Measurement And Related Uncertainties, Amanda Elizabeth Stark Apr 2020

Thermal Contact Resistance Measurement And Related Uncertainties, Amanda Elizabeth Stark

Mechanical & Aerospace Engineering Theses & Dissertations

Thermal contact resistance is an important parameter in detailed thermal analysis and design of aerospace systems. The ability to determine thermal contact resistance reliably can have a significant impact on the fidelity of thermal models—particularly for space applications. The 2004 NASA Langley Research Center thermal contact resistance test apparatus has been employed to evaluate two methods for inferring estimated interface surface temperatures so that thermal contact resistance can be calculated more accurately. The traditional method of extrapolation is a steady-state approach, while the new method utilizes inverse heat transfer techniques to account for inherent unsteadiness in these quasi-steady-state measurements ...


Investigating The Feasibility And Stability For Modeling Acoustic Wave Scattering Using A Time-Domain Boundary Integral Equation With Impedance Boundary Condition, Michelle E. Rodio Apr 2020

Investigating The Feasibility And Stability For Modeling Acoustic Wave Scattering Using A Time-Domain Boundary Integral Equation With Impedance Boundary Condition, Michelle E. Rodio

Mathematics & Statistics Theses & Dissertations

Reducing aircraft noise is a major objective in the field of computational aeroacoustics. When designing next generation quiet and environmentally friendly aircraft, it is important to be able to accurately and efficiently predict the acoustic scattering by an aircraft body from a given noise source. Acoustic liners are an effective tool for aircraft noise reduction and are characterized by a frequency-dependent impedance. Converted into the time-domain using Fourier transforms, an impedance boundary condition can be used to simulate the acoustic wave scattering by geometric bodies treated with acoustic liners

This work considers using either an impedance or an admittance (inverse ...


Through-Thickness Reinforcement And Repair Of Carbon Fiber Based Honeycomb Structures Under Flexure And Tension Of Adhesively Bonded Joints, Aleric Alden Sanders Apr 2020

Through-Thickness Reinforcement And Repair Of Carbon Fiber Based Honeycomb Structures Under Flexure And Tension Of Adhesively Bonded Joints, Aleric Alden Sanders

Mechanical & Aerospace Engineering Theses & Dissertations

Repair and reinforcement of composite honeycomb structures is an area of concern as higher demands are being placed on high strength, lightweight structural materials, such as carbon fiber reinforced plastics and corresponding honeycomb structures. A common issue with these structures is when a delamination in the facesheet may form and spread, leading to a failure scenario. An investigation of adding a through thickness reinforcement (TTR) to these structures at the sample level that undergo four-point-bending, tension, and joining methods is conducted throughout this thesis. The embedding of pultruded carbon fiber rods is found to be an ideal addition to composite ...


Energy Conservation And Heat Transfer Enhancement For Mixed Convection On The Vertical Galvanizing Furnace, Dan Mei, Yuzheng Zhu, Xuemei Xu, Futang Xing Jan 2020

Energy Conservation And Heat Transfer Enhancement For Mixed Convection On The Vertical Galvanizing Furnace, Dan Mei, Yuzheng Zhu, Xuemei Xu, Futang Xing

Mechanical & Aerospace Engineering Faculty Publications

The alloying temperature is an important parameter that affects the properties of galvanized products. The objective of this study is to explore the mechanism of conjugate mixed convection in the vertical galvanizing furnace and propose a novel energy conservation method to improve the soaking zone temperature based on the flow pattern and heat transfer characteristics. Herein, the present study applied the k-ε two-equation turbulence model to enclose the Navier-Stokes fluid dynamic and energy conservation equations, and the temperature distributions of the steel plate and air-flow field in the furnace were obtained for six Richardson numbers between 1.91 ⋅ 105 ...


Editorial For The Special Issue On Micro/Nano-Chip Electrokinetics, Volume Iii, Shizhi Qian, Xiangchun Xuan Jan 2020

Editorial For The Special Issue On Micro/Nano-Chip Electrokinetics, Volume Iii, Shizhi Qian, Xiangchun Xuan

Mechanical & Aerospace Engineering Faculty Publications

No abstract provided.


Electroosmotic Flow Of Viscoelastic Fluid In A Nanochannel Connecting Two Reservoirs, Lanju Mei, Shizhi Qian Nov 2019

Electroosmotic Flow Of Viscoelastic Fluid In A Nanochannel Connecting Two Reservoirs, Lanju Mei, Shizhi Qian

Mechanical & Aerospace Engineering Faculty Publications

Electroosmotic flow (EOF) of viscoelastic fluid with Linear Phan-Thien–Tanner (LPTT) constitutive model in a nanochannel connecting two reservoirs is numerically studied. For the first time, the influence of viscoelasticity on the EOF and the ionic conductance in the micro-nanofluidic interconnect system, with consideration of the electrical double layers (EDLs), is investigated. Regardless of the bulk salt concentration, significant enhancement of the flow rate is observed for viscoelastic fluid compared to the Newtonian fluid, due to the shear thinning effect. An increase in the ionic conductance of the nanochannel occurs for the viscoelastic fluid. The enhancement of the ionic conductance ...


Dynamic Response Modeling Of High-Speed Planing Craft With Enforced Acceleration, Gene Hou, Brain Johnson, Jonathan Degroff, Steven Trenor, Jennifer Michaeli Oct 2019

Dynamic Response Modeling Of High-Speed Planing Craft With Enforced Acceleration, Gene Hou, Brain Johnson, Jonathan Degroff, Steven Trenor, Jennifer Michaeli

Mechanical & Aerospace Engineering Faculty Publications

An approach is investigated in this study for structural dynamic analysis of a high-speed planing hull, in which the pointwise acceleration data collected from sea trials are enforced as base excitation. The paper first performed the full boat analysis of an 11-meter high speed craft for a period of one wave impact selected from each of nine seakeeping runs. The sea trial acceleration data collected from 11 accelerometers placed close to the centerline and the keel are enforced as input, while those from 3 accelerometers placed around the pilot cabin are selected for validation. The substructure dynamic analysis of the ...


Effect Of The Physical Micro-Environment On Cell Adhesion And Force Exertion, Mohamad Eftekharjoo Oct 2019

Effect Of The Physical Micro-Environment On Cell Adhesion And Force Exertion, Mohamad Eftekharjoo

Mechanical & Aerospace Engineering Theses & Dissertations

Physical characteristics of the microenvironment, such as geometry and stiffness, influence cell adhesion and contractile forces. Here, we determined how these physical factors influenced cell force exertion and adhesion in two specific contexts that have broad relevance.

Fibroblasts are cells in connective tissues that interact with a fibrous extracellular matrix (ECM) that have a predominantly one-dimensional (1D) (fibrillar) geometry. However, it has been unclear as to how the 1D nature of the fibrillar ECM influences the forces exerted by fibroblasts. Here, we used fibroblast cells adherent on fibronectin lines on polyacrylamide (PAA) gels of stiffness 13 and 45 kPa to ...


Extension Of A Penalty Method For Numerically Solving Constrained Multibody Dynamic Problems, Troy Newhart Oct 2019

Extension Of A Penalty Method For Numerically Solving Constrained Multibody Dynamic Problems, Troy Newhart

Mechanical & Aerospace Engineering Theses & Dissertations

Numerical analysis of constrained static and multibody dynamic systems has become an integral part of engineering analysis with the continued improvements in technology and software availability. Many methods currently exist for numerically solving constrained static and dynamic systems. The applicability of a penalty method for constrained static solutions is observed in many academic texts and papers. The appeal for using a penalty method in statics pertains to its ease of implementation, computational suitability, and accuracy. This thesis extends a static penalty method for use with constrained multibody dynamics to observe if the penalty method’s benefits are similar for a ...


Numerical Modeling Of Shoreline Response To Storm Tides And Sea Level Rise, Akash Sahu Oct 2019

Numerical Modeling Of Shoreline Response To Storm Tides And Sea Level Rise, Akash Sahu

Civil & Environmental Engineering Theses & Dissertations

In this study, an integrated hydrodynamic, wave, and sediment transport modeling approach is developed for predicting the spatiotemporal variation of erosion of a sandy shoreline due to storm surge, wave action, tidal variations, and relative sea level rise (RSLR). The study site is located at the northern most portion of the city of Norfolk, Virginia, and it is of importance to the city, both in terms of tourism and for the protection that it provides for upland properties against storms. The region, in general, experiences the highest rate of RSLR on the U.S. East Coast which should result in ...


Gesture Based Control Of Semi-Autonomous Vehicles, Brian Sanders Oct 2019

Gesture Based Control Of Semi-Autonomous Vehicles, Brian Sanders

Computational Modeling and Simulation Engineering Theses & Dissertations

The objective of this investigation is to explore the use of hand gestures to control semi-autonomous vehicles, such as quadcopters, using realistic, physics based simulations. This involves identifying natural gestures to control basic functions of a vehicle, such as maneuvering and onboard equipment operation, and building simulations using the Unity game engine to investigate preferred use of those gestures. In addition to creating a realistic operating experience, human factors associated with limitations on physical hand motion and information management are also considered in the simulation development process. Testing with external participants using a recreational quadcopter simulation built in Unity was ...


Computational Analysis And Design Optimization Of Convective Pcr Devices, Jung Il Shu Jul 2019

Computational Analysis And Design Optimization Of Convective Pcr Devices, Jung Il Shu

Mechanical & Aerospace Engineering Theses & Dissertations

Polymerase Chain Reaction (PCR) is a relatively novel technique to amplify a few copies of DNA to a detectable level. PCR has already become common in biomedical research, criminal forensics, molecular archaeology, and so on. Many have attempted to develop PCR devices in numerous types for the purpose of the lab-on-chip (LOC) or point-of-care (POC). To use PCR devices for POC lab testing, the price must be lower, and the performance should be comparable to the lab devices. For current practices with the existing methods, the price is pushed up higher partially due to too much dependence on numerous developmental ...


Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote Jul 2019

Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote

Mechanical & Aerospace Engineering Theses & Dissertations

Innovations in computer technology made way for Computational Fluid Dynamics (CFD) into engineering, which supported the development of new designs by reducing the cost and time by lowering the dependency on experimentation. There is a further need to make the process of development more efficient. One such technology is Artificial Intelligence. In this thesis, we explore the application of Artificial Intelligence (AI) in CFD and how it can improve the process of development.

AI is used as a buzz word for the mechanism which can learn by itself and make the decision accordingly. Machine learning (ML) is a subset of ...


Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali Jul 2019

Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali

Mechanical & Aerospace Engineering Theses & Dissertations

In epithelial tissues, epithelial cells adhere to each other as well as to the underlying extra-cellular matrix (ECM). E-cadherin-based intercellular junctions play an important role in tissue integrity. These junctions experience cell-generated mechanical forces via apparent adaptor proteins such as beta (β) catenin, alpha (α) catenin and vinculin. Abnormalities in these junctions may result in skin related diseases and cancers. Here, I devised methods to determine the endogenous intercellular force within cell pairs as well as in large epithelial islands. I further ascertained the factors that affect the level of inter-cellular tension.

Experiments with pairs of epithelial cells exogenously expressing ...


Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles Jul 2019

Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles

Mechanical & Aerospace Engineering Theses & Dissertations

The aim of this thesis is to explore methods to reduce the noise impact of unmanned aerial vehicles operating within acoustically sensitive environments by flight control system augmentation. Two methods are investigated and include: (i) reduction of sound generated by vehicle speed control while flying along a nominal path and (ii) reduction of acoustic exposure by vehicle path control while flying at a nominal speed. Both methods require incorporation of an acoustic model into the flight control system as an additional control objective and an acoustic metric to characterize primary noise sources dependent on vehicle state. An acoustic model was ...


Off Axis Compressive Response Of Ice-Templated Ceramics, Rahul Kumar Jujjavarapu Apr 2019

Off Axis Compressive Response Of Ice-Templated Ceramics, Rahul Kumar Jujjavarapu

Mechanical & Aerospace Engineering Theses & Dissertations

The off-axis compressive behavior of ice-templated ceramic was analyzed using experimental results and micro-mechanical model simulation. Ice-templated ceramics is a versatile processing technique used to manufacture anisotropic ceramic foam by exploiting the anisotropic growth characteristics and lamellar morphology. The ice-templating process results in processing-structure-property relationships determined by the microstructure. The processed alumina samples which were later manufactured by water jet machine from the freeze casting were tested under quasi-static off-axis loading conditions and were used to determine the mechanical properties of the material. Digital image correlation (DIC) was used to measure the strain response of ice-templated ceramic under off-axis loading ...


Characterization And Optimization Of A Propeller Test Stand, Colin Bruce Leighton Benjamin Apr 2019

Characterization And Optimization Of A Propeller Test Stand, Colin Bruce Leighton Benjamin

Mechanical & Aerospace Engineering Theses & Dissertations

In recent history, there has been a rapid rise in the use of drones, and they are expanding in popularity each year. The widespread use and future capabilities of these unmanned aerial vehicles (UAVs) will call for increased study and classification of propellers to maximize their performance. As a result, it is necessary to have continuity in the development, maximization, and optimization of propeller test stand’s capability to collect accurate and precise measurements. It is of significant advantage to have the capability of accurately characterizing a propeller based on its thrust and torque. In this study, a propeller test ...


Design And Manufacture Of An Inertial Cascade Impactor For Industrial Hygiene Purposes, Hector Joel Gortaire Apr 2019

Design And Manufacture Of An Inertial Cascade Impactor For Industrial Hygiene Purposes, Hector Joel Gortaire

Mechanical & Aerospace Engineering Theses & Dissertations

Inertial cascade impactors are devices commonly used for industrial hygiene and pharmaceutical studies. Their main purpose is to separate particulate matter suspended in aerosols according to their sizes, which can vary from over 10 µm to 0.5 µm. Their versatility and ease of operation make them suitable for on-site sampling; however, designing them requires a careful consideration of the different geometric parameters that characterize them.

In this thesis, a 5-stage inertial cascade impactor was designed, modelled, constructed, and tested. The main design parameter was the volumetric flow rate, 40 l/min, which was provided by a vacuum pump. By ...


Comparison Of Support Methods For Static Aerodynamic Testing And Validation Of A Magnetic Suspension And Balance System, Cameron K. Neill Apr 2019

Comparison Of Support Methods For Static Aerodynamic Testing And Validation Of A Magnetic Suspension And Balance System, Cameron K. Neill

Mechanical & Aerospace Engineering Theses & Dissertations

Magnetic suspension wind tunnels offer an alternative to traditional physical support methods. They allow for the collection of support interference free data and broader dynamic test capabilities than existing methods. Determination of dynamic aerodynamic characteristics is a crucial portion of the design of new re-entry capsules. A NASA initiative restored the 6-inch Magnetic Suspension and Balance System to support the design of a new MSBS for a supersonic wind tunnel. Before a new MSBS can be constructed, the characteristics of the current MSBS must be examined.

This thesis discusses the calibration and validation of the 6-inch MSBS. After calibration, three ...


Bayesian Model Averaging Based Storage Lifetime Assessment Method For Rubber Sealing Rings, Di Liu, Shaoping Wang, Chao Zhang, Mileta M. Tomovic Jan 2019

Bayesian Model Averaging Based Storage Lifetime Assessment Method For Rubber Sealing Rings, Di Liu, Shaoping Wang, Chao Zhang, Mileta M. Tomovic

Engineering Technology Faculty Publications

Rubber sealing ring is one of the most widely used seals. It is always stored for a period of time before put into use, especially in aeronautic and aerospace applications. It is necessary to evaluate the storage lifetime of rubber sealing rings. However, due to the long storage lifetime of rubber sealing rings, two issues need to be handled, including model uncertainty and lack of storage lifetime data. A Bayesian model averaging based storage lifetime assessment method for rubber sealing rings is proposed in this article. The Gamma distribution model and Weibull distribution model are selected as the candidate models ...


Numerical Study On The Dynamic Process Of Single Plume Flow In Thermal Convection With Polymers, Jian-Ping Cheng, Wei-Hua Cai, Hong-Na Zhang, Feng-Chen Li, Lian Shen, Shi-Zhi Qian Jan 2019

Numerical Study On The Dynamic Process Of Single Plume Flow In Thermal Convection With Polymers, Jian-Ping Cheng, Wei-Hua Cai, Hong-Na Zhang, Feng-Chen Li, Lian Shen, Shi-Zhi Qian

Mechanical & Aerospace Engineering Faculty Publications

A direct numerical simulation of single plume flow in thermal convection with polymers was carried out in a domain with 1:3 as the width to height ratio. The heat transport ability is weakened by adding polymers within the here-investigated governing parameter range. However, it is promoted when the maximum polymer extension L is increased. The distribution of vertical velocity and temperature indicates that the plume in the polymer solution case is speeded up and widens bigger as compared to that in the Newtonian fluid case. Inside the plume, polymer chains tend to release energy at the position where the ...


Interface Model Of Pem Fuel Cell Membrane Steady-Dtate Behavior, Russell L. Edwards, Ayodeji Demuren Oct 2018

Interface Model Of Pem Fuel Cell Membrane Steady-Dtate Behavior, Russell L. Edwards, Ayodeji Demuren

Mechanical & Aerospace Engineering Faculty Publications

Modeling works which simulate the proton-exchange membrane fuel cell with the computational fluid dynamics approach involve the simultaneous solution of multiple, interconnected physics equations for fluid flows, heat transport, electrochemical reactions, and both protonic and electronic conduction. Modeling efforts vary by how they treat the physics within and adjacent to the membrane-electrode assembly (MEA). Certain approaches treat the MEA not as part of the computational domain, but rather an interface connecting the anode and cathode computational domains. These approaches may lack the ability to consistently model catalyst layer losses and MEA ohmic resistance. This work presents an upgraded interface formulation ...


Electrochemical Hydrogenation Of Acetone To Produce Isopropanol Using A Polymer Electrolyte Membrane Reactor, Chen Li, Ashanti M. Sallee, Xiaoyu Zhang, Sandeep Kumar Oct 2018

Electrochemical Hydrogenation Of Acetone To Produce Isopropanol Using A Polymer Electrolyte Membrane Reactor, Chen Li, Ashanti M. Sallee, Xiaoyu Zhang, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

Electrochemical hydrogenation (ECH) of acetone is a relatively new method to produce isopropanol. It provides an alternative way of upgrading bio-fuels with less energy consumption and chemical waste as compared to conventional methods. In this paper, Polymer Electrolyte Membrane Fuel Cell (PEMFC) hardware was used as an electrochemical reactor to hydrogenate acetone to produce isopropanol and diisopropyl ether as a byproduct. High current efficiency (59.7%) and selectivity (>90%) were achieved, while ECH was carried out in mild conditions (65 degrees C and atmospheric pressure). Various operating parameters were evaluated to determine their effects on the yield of acetone and ...


Accurate Flexible Refinement Of Atomic Models Against Medium-Resolution Cryo-Em Maps Using Damped Dynamics, Julio A. Kovacs, Vitold E. Galkin, Willy Wriggers Sep 2018

Accurate Flexible Refinement Of Atomic Models Against Medium-Resolution Cryo-Em Maps Using Damped Dynamics, Julio A. Kovacs, Vitold E. Galkin, Willy Wriggers

Mechanical & Aerospace Engineering Faculty Publications

Background: Dramatic progress has recently been made in cryo-electron microscopy technologies, which now make possible the reconstruction of a growing number of biomolecular structures to near-atomic resolution. However, the need persists for fitting and refinement approaches that address those cases that require modeling assistance.

Methods: In this paper, we describe algorithms to optimize the performance of such medium-resolution refinement methods. These algorithms aim to automatically optimize the parameters that define the density shape of the flexibly fitted model, as well as the time-dependent damper cutoff distance. Atomic distance constraints can be prescribed for cases where extra containment of parts of ...


A Stepwise Compression-Relaxation Testing Method For Tissue Characterization And Tumor Detection Via A Two-Dimensional Tactile Sensor, Yichao Yang Jul 2018

A Stepwise Compression-Relaxation Testing Method For Tissue Characterization And Tumor Detection Via A Two-Dimensional Tactile Sensor, Yichao Yang

Mechanical & Aerospace Engineering Theses & Dissertations

This dissertation presents a stepwise compression-relaxation (SCR) testing method built upon a two-dimensional (2D) tactile sensor for mechanical characterization of soft tissues and tumor detection. The core of the 2D sensor entails one whole polydimethylsiloxane (PDMS) microstructure embedded with a 3×3 sensing-plate/transducer array. A soft sample was compressed by the 2D sensor with a step incremental depth at a ramp speed, and then relaxed for certain hold time. When a soft sample was compressed by the 2D sensor, the sensing-plates translated the sample response at different tissue sites to the sensor deflections, which were registered as resistance changes ...


Epithelial Sheet Response To External Stimuli, Yashar Bashirzadeh Jul 2018

Epithelial Sheet Response To External Stimuli, Yashar Bashirzadeh

Mechanical & Aerospace Engineering Theses & Dissertations

Mechanical communication of adherent cells with their micro-environment is mediated by cytoskeletal and adhesion proteins. These mechanical links aid tissues in maintaining their coherence in the context of the surrounding extra cellular matrix (ECM). Epithelial tissues exert force on the ECM through integrin-based junctions and maintain their coherency through E-cadherin-based cell-cell junctions while dynamically undergoing collective migration. Such a complex network of communication involving the cell cytoskeleton and adhesion proteins modulates the tissue's response to external cues. Two distinct forms of such external stimuli are those of electrical and mechanical origin.

Epithelial tissues quickly respond to physiologically relevant electric ...