Mechanical Engineering Commons^™

Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb

Theses and Dissertations

Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …

Analyzing Heat Generated From Electro-Osmotic Flow Utilizing Computational Fluid Dynamics, Jordan Elizabeth Grothe

Honors Thesis

Without extensive vascularization, the transfer of fluid and nutrients through human tissue is limited to diffusion and weak interstitial flow. Electroosmosis, or the flow of fluid driven by an electrical field, has become a promising solution. Scientists have begun applying electricity to human tissue to promote stronger interstitial flow; however, optimization of this process has proven to be a challenge due to ohmic heating. Cells function within a small range of temperatures and exposure to voltages exceeding the threshold will cause cells to degrade and die prematurely. This research seeks to better understand and quantify the range of voltage where …

Theory Of Development And Improvement Of The Mathematical Model Of The Methodology Of Public Control In The Management Of Occupational Safety And Industrial Risks, Aliakbar Khamidullaevich Rasulev, Sunnatilla Suleymanovich Suleymanov, Nodira Bakhadirzhanovna Gaibnazarova

Technical science and innovation

The article develops and analyzes a mathematical model based on a logical flowchart of the methodology of public control in the management of occupational safety and industrial risks and probability theory, according to the model, the results of compliance with the requirements of social cooperation on occupational safety lead to a sharp increase in the probability of reliability, management efficiency becomes higher. Analysis of the mathematical model of the developed logical flowchart based on probability theory has shown that when the parties cooperate to monitor the results of compliance with labor protection requirements, they lead to a sharp increase in …

Solving Water Resources Problems - Water Saving In The Republic Of Uzbekistan, Rustam Muxammatdjanovich Raximov

Technical science and innovation

In this article we will talk about the problems of water resources in the Republic of Uzbekistan. The problem of drinking water supply, solutions to provide drinking water to the population of Uzbekistan. The largest consumers of fresh water in Uzbekistan are farmers. Due to outdated infrastructure, 40% of water is wasted. Rising food prices and the risk of spreading disease are the first signs of water shortages that we may experience in the coming еars. Uzbekcosmos told how to solve the problem. Water is an invaluable resource used not only in the home, but also in the production and …

Selective Oxidation Of Iron In Chalcopyrite For Enhanced Copper Recovery, Khojiakbar Shuxrat O'G'Li Sultonov, Shokhrukh Toshpulatovich Khojiev, Gulnoza Berdiyor Qizi Beknazarova, Malika Sayfullayevna Saidova

Technical science and innovation

This study explores the thermodynamic feasibility of selectively oxidizing iron contained in chalcopyrite mineral while preventing the oxidation of copper sulphide, with the ultimate goal of enhancing the copper concentration in the sulphide concentrate. A redox reaction in the solid phases between chalcopyrite and copper (I) oxide was constructed and subjected to thermodynamic analysis. The research identifies a crucial temperature range of 498-598 K (225-325 °C) as the most favourable for the redox reaction. The equilibrium constants at the selected optimal temperatures, 1.152 for chalcopyrite and 1.137 for copper (I) oxide, indicate that the redox reaction adheres to the expected …

Modelling Of Heat Transfer In An Air Solar Collector, Shakhnoza Abduvaxitovna Sultanova, Jasur Esirgapovich Safarov, A.A. Mambetsheripova

Technical science and innovation

This study is the prediction, depending on time and different geographical and climatic situations, of different operating parameters: solar radiation, ambient and outlet coolant temperature, heat exchange coefficients and losses. All these determine, in the absence of measurements, the efficiency of the system modelled with existing models with respect to these parameters. These models are usually compared with experimental results. Before modelling, it is necessary to investigate the different heat transfer and exchange regimes that exist between the different elements of this system in order to eventually have a system of equations governing this exchange. The modelling principle is to …

Implementing A Solar Photovoltaic Station In Watering Systems Utilizing Complex Software, Akbarxon Sarvar O'G'Li Uroqov, Faxriddin Jaylovovich Nosirov, G'Olibjon Pardayevich Arzikulov, Zarina Amriddin Qizi Sayfutdinova

Technical science and innovation

This article explores the benefits of transitioning from traditional agricultural irrigation systems to more cost-effective alternatives powered by renewable energy sources. By integrating solar photovoltaic technology into irrigation processes, significant reductions in resource wastage, estimated at 45-50%, are achievable through the implementation of drip irrigation techniques. This results in enhanced agricultural productivity. Moreover, the utilization of solar panels in green zones mitigates surface temperature increases, contributing to a 2-5% boost in electricity production. Currently, irrigation facilities primarily rely on the main energy grid. However, transitioning to renewable energy sources decreases reliance on non-renewable fuels, reduces greenhouse gas emissions, and fosters …

Research Of The Influence Of Dust On Photovoltaic Modules, Anvarjon Mirolimov, Xalmurat Iliev

Technical science and innovation

The influence of dust concentrations on the current-voltage characteristics (voltampere characteristics) of photovoltaic modules (PVM) based on crystalline silicon in laboratory conditions. It was investigated how an uncleaned panel affects the output power. The tests were carried out in the city of Tashkent on the territory of the “National Research Institute of Renewable Energy Sources”. The objects were located co-plurally as specified in GOST R 60904-1 Photoelectric devices. Part 1. Measurement of current-voltage characteristics. Measurements of a cleaned photovoltaic module with a maximum power of 330 W and not a cleaned one of 236 W were obtained. Based on the …

Use Of Mathematical Skills For Technical Condition Assessment Of Power Autotransformers, Dilafruz Rustamjon Qizi Abdullabekova, Nurali Berdiyorovich Pirmatov

Technical science and innovation

In this paper, we review innovative approaches to assess the technical condition of autotransformers using mathematical methods. The main purpose of these methods is to increase the efficiency of diagnostics and prevent possible failures in power systems. The developed mathematical expression is based on complex data analysis, application of statistical methods and machine learning technologies. This makes it possible to achieve more accurate and earlier detection of potential problems. As a result of these innovative approaches, the possibilities for early detection and prevention of faults are significantly increased. This is important for ensuring the smooth operation of power systems and …

Quantitative Assessment And Characterization Of Tool Wear Phenomena In Advanced Manufacturing Processes, Oybek Valijonovich Tuyboyov

Technical science and innovation

This paper explores the quantitative assessment and characterization of tool wear phenomena in advanced manufacturing processes, employing a multifaceted approach encompassing traditional measurements, image processing, machine learning, and predictive modeling. The study emphasizes the intricate dynamics of tool wear and its direct impact on cutting tool performance, addressing challenges in real-time monitoring and optimization of machining operations. Traditional methods like VBmax measurement are juxtaposed with advanced techniques such as the improved conditional generative adversarial net with a high-quality optimization algorithm (CGAN-HQOA), efficient channel attention destruction and construction learning (ECADCL), and shape descriptors based on contour, moments, orientations, and texture. Artificial …

A Study On The Influence Of Cutting Parameters On Surface Roughness And Visualization Through Contour Plots And 3d Surface Profiles, Zayniddin Nosirovich Muxiddinov

Technical science and innovation

This research investigates the intricate relationship between cutting parameterscutting speed, feed rate, and depth of cut and surface roughness in machining processes. Surface roughness is a key determinant of machined surface quality, and optimizing cutting parameters is crucial for achieving superior finishes. Employing advanced visualization techniques, including contour plots and 3D surface profiles, the study offers a comprehensive exploration of surface topography dynamics. Statistical analyses and regression modeling enhance the quantitative understanding of how cutting parameters interact to shape surface roughness. The research affirms the significant influence of cutting speed, feed rate, and depth of cut, providing practical insights for …

Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of Gait, Timothy S. Jain

Master's Theses

Total ankle replacement (TAR) implants are an effective option to restore the range of motion of the ankle joint for arthritic patients. An effective tool for analyzing these implants’ mechanical performance and longevity in-silico is finite element analysis (FEA). ABAQUS FEA was used to statically analyze the von Mises stress and contact pressure on the articulating surface of the bearing component in two newly installed fixed-bearing total ankle replacement implants (the Wright Medical INBONE II and the Exactech Vantage). This bearing component rotates on the talar component to induce primary ankle joint motion of plantarflexion and dorsiflexion. The stress response …

Effect Of Foot Additional Mass On The Clinical Angles Of Knee Extension Exercise, Dumitru I. Caruntu, Alfirio Trejo, Eric Rodriguez, Camila T. Alvarez B

Mechanical Engineering Faculty Publications and Presentations

This study investigates the effect of foot additional mass on the abduction and internal rotation knee angles during knee extension exercise. Three subjects (two male and one female) performed four sets of ten repetitions of the knee extension exercise for the right leg. For the first set, the subject performed the exercise with no additional weight. For each set after, weight was added around the subject’s right foot and the subject was allowed a rest period before beginning the next set. The weights for sets 1, 2, 3, and 4 were 0.00kg (no additional weight) ,0.82kg, 1.64kg, and 2.27kg respectively. …

Left Ventricle Function And Post-Transcriptional Events With Exercise Training In Pigs, Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Traci L. Jones, Marlee Poole, Mark A. Sarzynski, Michael R. Zile, Tarek Shazly, Francis G. Spinale

Faculty Publications

Background

Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microRNAs (miRs)) are poorly understood. This project tested the central hypothesis that adaptive LV remodeling resulting from a large animal exercise training protocol, would be directly associated with specific miRs responsible for regulating pathways relevant to LV myocardial stiffness and geometry.

Methods and results

Pigs (n = 9; 25 Kg) underwent a 4 week exercise training protocol (10 degrees elevation, 2.5 mph, 10 min, 5 days/week) whereby LV chamber stiffness (KC) …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications, Part 2

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction-a measure of …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications, Part 2

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction—a measure of …

Research On An Improved Cotton Cleaner Unit, Muzaffar Djurayev, Sherqul Hakimov, Ilhom Abbazov, Rashid Kaldybaev

Technical science and innovation

This article analyzes the results of changes to the working parts of a cotton cleaning unit from small and large impurities. It is known that the UXK installation uses continuous cleaning technology, that is, the cotton entering the purifier is cleaned in all its cleaning sections and then transferred to another process. In these sections, pieces of cotton wool from the separated waste are regenerated in a separate drum. Existing purifier suppliers use a manually operated mechanical system to monitor its performance. These factors do not make it possible to control the cleaning process when the quality indicators of cotton …

Polymerizing Actin Regulates Myosin-Independent Mechanosensing By Modulating Actin Elasticity And Flow Fluctuation, Nikhil Mittal, Etienne Michels, Kathleen Pakenas, Shaina P. Royer-Weeden, Sangyoon J. Han

Michigan Tech Publications, Part 2

The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has stronger contribution than Arp2/3. Interestingly, we report a four-fold reduction in traction of cells when both Arp2/3 and myosin were inhibited, compared to cells with only myosin inhibition, while there was only a slight …

Myosin-Independent Stiffness Sensing By Fibroblasts Is Regulated By The Viscoelasticity Of Flowing Actin, Nikhil Mittal, Etienne B. Michels, Andrew E. Massey, Yunxiu Qiu, Shaina P. Royer-Weeden, Bryan R. Smith, Alexander X. Cartagena-Rivera, Sangyoon J. Han

Michigan Tech Publications, Part 2

The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions, triggering differential mechanoresponses. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has a stronger contribution than Arp2/3 to both traction and actin flow. Intriguingly, despite only slight changes in F-actin flow speed observed in cells with the combined inhibition of Arp2/3 and myosin …

Mathematical Modeling Of Fruit Drying And System Analysis Of The Process (On The Example Of Persimmon), Gani Dadayev, Jasur Safarov, Shakhnoza Sultanova, Qobiljon Muxiddinov

Technical science and innovation

Vegetable raw materials, as an object of drying, are characterized by a large amount of water and a low content of dry substances. Vegetable raw materials have a capillary-porous structure. Food products contain both bound and free moisture at the same time. The removal of moisture from the material during drying depends on the total moisture content and the form of connection of moisture with the material. Adsorption and osmotic - bound moisture is retained at the interface of colloidal particles with the environment. Food products contain both bound and free moisture at the same time. The quantitative ratio between …

Improvement Of Convective Drying Equipment, A Ponasenko, Jasur Safarov, Shaxnoza Sultanova

Technical science and innovation

Drying of agricultural raw materials is an energy-consuming but integral process. Therefore, increasing the efficiency of drying and improving the quality indicators of dried material at minimum material and energy costs is relevant for producers of agricultural products. By present time numerous researches on improvement of constructions and processes of work of dryers providing satisfactory parameters of energy saving have been carried out. In some scientific materials it is shown that the use of generative gas and straw as fuel allows to reduce energy costs for the drying process in the fluidised bed dryer by 10-30%, the quality of seeds …

Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov

Technical science and innovation

The article discusses the errors associated with the moisture measuring transducer that is based on the cylindrical electrode, along with their sources and calculation formulas for error elimination. The initial capacitance of the capacitive electrode humidity converter is dependent on its geometric parameters, such as the radii of the electrodes and their length. Accurate calculation of these geometric parameters enables the reduction of regular measurement errors in the input and switching circuit of the moisture converter to a minimum value, resulting in a significant increase in the informativeness and accuracy of the output signal. Consequently, some sources of measurement errors …

Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova

Technical science and innovation

autotransformers, methods, diagnostics, efficiency, monitoring.Particular attention is given to analyzing the gas composition of transformer oil, which is a sensitive indicator of various defects such as thermal breakdown and heating. In addition, methods based on the measurement of external magnetic field strength are discussed. This technique provides a unique opportunity to detect magnetic anomalies associated with possible defects in the structural components of the transformer. The article emphasizes that successful monitoring requires an integrated approach, combining different techniques. The authors analyze the advantages and limitations of each method and offer practical recommendations for integrating these methods into maintenance systems. In …

Influence Of Foil Stamping Parameters On Image Quality, Khalima Abishevna Babakhanova, Mukhlisa Ergashevna Khasanova, Aziz Azimjonovich Soadatov, Nigora Junaydullaevna Sadriddinova

Technical science and innovation

The paper evaluates the influence of technological process parameters, namely die temperature and pressure force, on the quality of foil stamping, which is one of the types of finishing having a wide range of applications due to giving unique decorative and protective elements to printed products. When evaluating the influence of process parameters on the linearity and coverability of the image, it was found that the pressure force has less influence on the result than the temperature. According to the data of the study, it can be concluded that the maximum percentage of completeness of covering is achieved at a …

Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu

Engineering Technology Faculty Publications

This paper thoroughly examines the advancements and challenges in the field of additively manufactured Functionally Graded Materials (FGMs). It delves into conceptual approaches for FGM design, various manufacturing techniques, and the materials employed in their fabrication using additive manufacturing (AM) technologies. This paper explores the applications of FGMs in diverse fields, including structural engineering, automotive, biomedical engineering, soft robotics, electronics, 4D printing, and metamaterials. Critical issues and challenges associated with FGMs are meticulously analyzed, addressing concerns related to production and performance. Moreover, this paper forecasts future trends in FGM development, highlighting potential impacts on diverse industries. The concluding section summarizes …

Instantaneous Generation Of Subject-Specific Finite Element Models Of The Hip Capsule, Ahilan Anantha-Krishnan, Casey A. Myers, Clare K. Fitzpatrick, Chadd W. Clary

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Subject-specific hip capsule models could offer insights into impingement and dislocation risk when coupled with computer-aided surgery, but model calibration is time-consuming using traditional techniques. This study developed a framework for instantaneously generating subject-specific finite element (FE) capsule representations from regression models trained with a probabilistic approach. A validated FE model of the implanted hip capsule was evaluated probabilistically to generate a training dataset relating capsule geometry and material properties to hip laxity. Multivariate regression models were trained using 90% of trials to predict capsule properties based on hip laxity and attachment site information. The regression models were validated using …

Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail

Theses and Dissertations

Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …

Indicators Affecting Passenger Service Processes And Their Scientific Interpretation, Maxliyoxon Madaminova Maxamatjon Qizi, Saidazim Amanullayevich Ganihodjayev

Technical science and innovation

Many traffic flow parameters affect the performance of the road network at high voltage. These are low vehicle speeds, high vehicle distances relative to road capacity, and density per unit time (lane occupancy). In turn, a number of factors affect the decrease in traffic speed: the presence of slow-moving vehicles in the stream; pedestrians crossing the road irregularly; increase in traffic flow, etc. The issues of public transportation depend on many factors, each of which requires a separate approach and a complex solution. In large cities around the world, the quality indicators of public transport services, including the issues of …

Multi-Mode Regulation Of The Drying Process Of Industrial Gas, Isamidin Xakimovich Sidikov Pr, Nashvandova Gulruxsor Murot Qizi Phd

Technical science and innovation

Currently, much attention is paid to the issue of energy efficiency of gas processing enterprises. The continuous growth of world prices for energy resources requires constant improvement of the management system, providing the most optimal conditions for the flow of technological processes. A conceptual model of the heat-mass transfer process occurring in the absorber as an object of research has been developed, which characterizes the relationship of the variables involved in the drying process of natural gas, control, measurable and immeasurable, as well as controlled parameters have been selected, which are used to develop and study a mathematical model of …

The Interaction Of The Cotton Piece With The Piles Of The Scrabble Cotton Drum, Fazliddin Egamberdiev, Ilkhom Abbazov, Oybek Kholmuratov, Rashid Kaldybaev

Technical science and innovation

This article presents the results of an analytical study of the process of loosening and cleaning raw cotton from small debris by pileging working bodies of purifiers, on the basis of which directions for further research were chosen to optimize the parameters of the developed pile drum with spherical piles and rubber strips. Cotton entering production contains impurities. The processes of loosening and cleaning the fiber shreds are key in the initial stages of ginning, as they prepare the raw cotton for ginning and directly affect the reliability, productivity of these processes and the quality of the resulting fiber. Weed …