Open Access. Powered by Scholars. Published by Universities.®

Mechanical Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Nanoscience and Nanotechnology

2016

Active stiffening

Articles 1 - 1 of 1

Full-Text Articles in Mechanical Engineering

Active Stiffening Of F-Actin Network Dominated By Structural Transition Of Actin Filaments Into Bundles, Shengmao Lin, Xinwei Han, Gary C.P. Tsui, David Hui, Linxia Gu Jan 2016

Active Stiffening Of F-Actin Network Dominated By Structural Transition Of Actin Filaments Into Bundles, Shengmao Lin, Xinwei Han, Gary C.P. Tsui, David Hui, Linxia Gu

Mechanical & Materials Engineering Faculty Publications

Molecular motor regulated active contractile force is key for cells sensing and responding to their mechanical environment, which leads to characteristic structures and functions of cells. The F-actin network demonstrates a two-order of magnitude increase in its modulus due to contractility; however, the mechanism for this active stiffening remains unclear. Two widely acknowledged hypotheses are that active stiffening of F-actin network is caused by (1) the nonlinear force-extension behavior of cross-linkers, and (2) the loading mode being switched from bending to stretching dominated regime. Direct evidence supporting either theory is lacking. Here we examined these hypotheses and showed that a ...