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Engineering Science and Materials Commons

Open Access. Powered by Scholars. Published by Universities.®

2015

Other Engineering Science and Materials

University of Nebraska - Lincoln

Gene therapy

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Full-Text Articles in Engineering Science and Materials

Mammalian Synthetic Biology: Emerging Medical Applications, Zoltan Kis, Hugo Sant'ann Pereira, Takayuki Homma, Ryan M. Pedrigi, Rob Krams Jan 2015

Mammalian Synthetic Biology: Emerging Medical Applications, Zoltan Kis, Hugo Sant'ann Pereira, Takayuki Homma, Ryan M. Pedrigi, Rob Krams

Mechanical & Materials Engineering Faculty Publications

In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology.We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and posttranslational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks ...