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Full-Text Articles in Engineering Science and Materials
Characterization Of Novel Akermanite:Poly-E-Caprolactone Scaffolds For Bone Tissue Engineering Aapplications Combined With Human Adipose-Derived Stem Cells, Andre S. Zanetti
Characterization Of Novel Akermanite:Poly-E-Caprolactone Scaffolds For Bone Tissue Engineering Aapplications Combined With Human Adipose-Derived Stem Cells, Andre S. Zanetti
LSU Doctoral Dissertations
The development of porous materials useful as scaffolds for the sustained three-dimensional (3D) growth of human adipose-derived stem cells (hASC) is of particular interest to facilitate healing after musculoskeletal injuries. In this study, a composite porous material obtained by blending akermanite with poly-e-caprolactone (PCL) is proposed as novel alternative to bone tissue regeneration. The objectives of this study are (1) to characterize the akermanite:PCL scaffold properties; (2) to investigate the in vitro osteogenic potential of hASC loaded to optimal akermanite:PCL scaffolds; (3) to assess the metabolic activity and osteogenesis of hASC loaded to optimal akermanite:PCL scaffolds post-thawing using optimal cryopreservation …