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University of Pennsylvania

Kinesiology

Rheology

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The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten Jan 2015

The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten

Publicly Accessible Penn Dissertations

In the past decades it has become clear that the mechanical properties of tissues are important for healthy functioning. The mechanical properties of tissues and their load-bearing components found in the extracellular matrix (ECM) have been tested mechanically to provide more insight. However, there is a discrepancy between tissue and ECM mechanics. In this thesis this discrepancy is investigated with a novel multiaxial rheology method, which addresses a physiologically relevant combination of shear and axial strains. Blood clots are used to study the effect of cell traction and cell packing on ECM mechanics.

The results show that ECM networks compression ...