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University of Pennsylvania

Biomedical

Roughness

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Non-Specific Interactions Between Cationic Nanoparticle-Polymer Composites And Biomolecules, Matthew Alexander Caporizzo Jan 2014

Non-Specific Interactions Between Cationic Nanoparticle-Polymer Composites And Biomolecules, Matthew Alexander Caporizzo

Publicly Accessible Penn Dissertations

This dissertation describes the consequences of non-specific binding between cationic nanoparticles (NPs) and biological materials ranging from persistence length reduction of single actin filaments, to modified kinetics of myosin V motility, and culminating with correlating THP-1 cell metabolic stress to viscoelastic changes. The bulk of the thesis (chapters 3-5), utilizes optically transparent polymer-NP composites with controllable hierarchical roughness to tune the interaction strength between actin filaments and the surface and impact myosin V kinetics. To generate hierarchical roughness, precise control over the thermodynamics and dynamics of NH2-functionalized NPs in polystyrene-ran-acrylic acid (SAA) is demonstrated in chapter 3. In ...