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University of Pennsylvania

Biomedical

Myocardial Infarction

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Injectable Hydrogels For Local Protein Delivery To Engineer Myocardial Remodeling, Brendan Patrick Purcell Jan 2013

Injectable Hydrogels For Local Protein Delivery To Engineer Myocardial Remodeling, Brendan Patrick Purcell

Publicly Accessible Penn Dissertations

The endogenous tissue remodeling events that occur following a myocardial infarction (MI) are inadequate to maintain left ventricular (LV) function, and the progression towards heart failure is often inevitable. Our increased understanding of protein regulators of post MI remodeling provides the opportunity to intervene and engineer tissue remodeling through exogenous protein delivery. The global hypothesis of this dissertation was that the local delivery of therapeutic proteins (SDF-1alpha and TIMP-3) from injectable hyaluronic acid (HA) hydrogels attenuates adverse post MI remodeling processes by providing sustained concentrations of bioactive signals within the remodeling myocardium.

To test this hypothesis, HA based hydrogels were ...