Open Access. Powered by Scholars. Published by Universities.®

Engineering Science and Materials Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 5 of 5

Full-Text Articles in Engineering Science and Materials

Influence Of Flow Rate, Nozzle Speed, Pitch And The Number Of Passes On The Thickness Of S1805 Photoresist In Suss Microtec As8 Spray Coater, Rohan Sanghvi, Gyuseok Kim Oct 2019

Influence Of Flow Rate, Nozzle Speed, Pitch And The Number Of Passes On The Thickness Of S1805 Photoresist In Suss Microtec As8 Spray Coater, Rohan Sanghvi, Gyuseok Kim

Tool Data

S1805 positive photoresist has been deposited on single crystalline Si wafers using a Suss MicroTec Alta Spray. The influence of flow rate, nozzle speed, pitch and number of passes on the thickness of the photoresist was studied. Results show that the thickness of S1805 is linearly proportional to the flow rate and number of passes, and inversely proportional to the nozzle speed and pitch.


Engineering Extracellular Matrix Signals Into Fibrous Hyaluronic Acid Hydrogels, Ryan Joseph Wade Jan 2015

Engineering Extracellular Matrix Signals Into Fibrous Hyaluronic Acid Hydrogels, Ryan Joseph Wade

Publicly Accessible Penn Dissertations

Hydrogels have gained widespread use in biomedical applications for their ability to mimic certain features of the natural extracellular matrix (ECM) including tissue-like mechanics, water-swollen environments, and biodegradability. Despite these advantages, hydrogels typically do not present the fibrous architecture of natural ECM, even though this structure can guide cell behavior and tissue function. With this in mind, the overall goal of this dissertation is the translation of hydrogels from hyaluronic acid (HA) macromers into more complex, fibrous networks with spatiotemporal control. First, HA macromers that contain protease-cleavable and fluorescent peptides were synthesized and shown to form both isotropic hydrogels and ...


The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten Jan 2015

The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten

Publicly Accessible Penn Dissertations

In the past decades it has become clear that the mechanical properties of tissues are important for healthy functioning. The mechanical properties of tissues and their load-bearing components found in the extracellular matrix (ECM) have been tested mechanically to provide more insight. However, there is a discrepancy between tissue and ECM mechanics. In this thesis this discrepancy is investigated with a novel multiaxial rheology method, which addresses a physiologically relevant combination of shear and axial strains. Blood clots are used to study the effect of cell traction and cell packing on ECM mechanics.

The results show that ECM networks compression ...


Non-Specific Interactions Between Cationic Nanoparticle-Polymer Composites And Biomolecules, Matthew Alexander Caporizzo Jan 2014

Non-Specific Interactions Between Cationic Nanoparticle-Polymer Composites And Biomolecules, Matthew Alexander Caporizzo

Publicly Accessible Penn Dissertations

This dissertation describes the consequences of non-specific binding between cationic nanoparticles (NPs) and biological materials ranging from persistence length reduction of single actin filaments, to modified kinetics of myosin V motility, and culminating with correlating THP-1 cell metabolic stress to viscoelastic changes. The bulk of the thesis (chapters 3-5), utilizes optically transparent polymer-NP composites with controllable hierarchical roughness to tune the interaction strength between actin filaments and the surface and impact myosin V kinetics. To generate hierarchical roughness, precise control over the thermodynamics and dynamics of NH2-functionalized NPs in polystyrene-ran-acrylic acid (SAA) is demonstrated in chapter 3. In ...


Injectable Hydrogels For Local Protein Delivery To Engineer Myocardial Remodeling, Brendan Patrick Purcell Jan 2013

Injectable Hydrogels For Local Protein Delivery To Engineer Myocardial Remodeling, Brendan Patrick Purcell

Publicly Accessible Penn Dissertations

The endogenous tissue remodeling events that occur following a myocardial infarction (MI) are inadequate to maintain left ventricular (LV) function, and the progression towards heart failure is often inevitable. Our increased understanding of protein regulators of post MI remodeling provides the opportunity to intervene and engineer tissue remodeling through exogenous protein delivery. The global hypothesis of this dissertation was that the local delivery of therapeutic proteins (SDF-1alpha and TIMP-3) from injectable hyaluronic acid (HA) hydrogels attenuates adverse post MI remodeling processes by providing sustained concentrations of bioactive signals within the remodeling myocardium.

To test this hypothesis, HA based hydrogels were ...