Open Access. Powered by Scholars. Published by Universities.®

Engineering Science and Materials Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 5 of 5

Full-Text Articles in Engineering Science and Materials

A New Approach To Multiplanar, Real-Time Simulation Of Physiological Knee Loads And Synthetic Knee Components Augmented By Local Composition Control In Fused Filament Fabrication, Joshua Taylor Green Jan 2018

A New Approach To Multiplanar, Real-Time Simulation Of Physiological Knee Loads And Synthetic Knee Components Augmented By Local Composition Control In Fused Filament Fabrication, Joshua Taylor Green

Open Access Theses & Dissertations

Despite numerous advances in biomedical engineering, few developments in surgical simulation have been made outside of computational models. Cadavers remain the primary media on which surgical research and simulation is conducted. Most attempts to quantify the effects of orthopedic surgical methods fail to achieve statistical significance due to limited quantities of cadaver specimen, large variations among the cadaver population, and a lack of repeatability among measurement techniques. The general purpose of the research covered in this dissertation is to develop repeatable simulation of physiological loads and develop techniques to fabricate a synthetic-based replacement of cadaver specimens. Future work applying this ...


Mechanics Of Fluctuating Elastic Plates And Fiber Networks, Xiaojun Liang Jan 2017

Mechanics Of Fluctuating Elastic Plates And Fiber Networks, Xiaojun Liang

Publicly Accessible Penn Dissertations

Lipid membranes and fiber networks in biological systems perform important mechanical functions at the cellular and tissue levels. In this thesis I delve into two detailed problems -- thermal fluctuation of membranes and non-linear compression response of fiber networks. Typically, membrane fluctuations are analysed by decomposing into normal modes or by molecular simulations. In the first part of my thesis, I propose a new semi-analytic method to calculate the partition function of a membrane. The membrane is viewed as a fluctuating von Karman plate and discretized into triangular elements. Its energy is expressed as a function of nodal displacements, and then ...


The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten Jan 2015

The Effect Of Cell Contractility And Packing On Extracellular Matrix And Soft Tissue Rheology, Anne Sofieke Geertruide Van Oosten

Publicly Accessible Penn Dissertations

In the past decades it has become clear that the mechanical properties of tissues are important for healthy functioning. The mechanical properties of tissues and their load-bearing components found in the extracellular matrix (ECM) have been tested mechanically to provide more insight. However, there is a discrepancy between tissue and ECM mechanics. In this thesis this discrepancy is investigated with a novel multiaxial rheology method, which addresses a physiologically relevant combination of shear and axial strains. Blood clots are used to study the effect of cell traction and cell packing on ECM mechanics.

The results show that ECM networks compression ...


The Particle Based Moving Interface Method For Soft Matter Mechanics And Fluid/Membrane Interactions With Applications To Biological Cells, Louis Cyrille Foucard Jan 2014

The Particle Based Moving Interface Method For Soft Matter Mechanics And Fluid/Membrane Interactions With Applications To Biological Cells, Louis Cyrille Foucard

Civil Engineering Graduate Theses & Dissertations

The mechanics of the interaction between a fluid and a soft interface (such as an elastic membrane or shell) undergoing large deformations appears in many places, such as in biological systems or industrial processes. We present here an Eulerian approach that describes the mechanics of an interface and its interactions with a surrounding fluid via the so-called Navier boundary condition. The interface is modeled as a curvilinear surface with arbitrary mechanical properties across which discontinuities in pressure and tangential fluid velocity can naturally be enforced using a modified version of the extended finite element method. The tracking and evolution of ...


Fish Skin: A Thin, Flexible, Protective Membrane, Natasha Elaine Funk Jan 2014

Fish Skin: A Thin, Flexible, Protective Membrane, Natasha Elaine Funk

Civil Engineering Graduate Theses & Dissertations

Although there have been recent efforts to characterize the important structural characteristics of fish scales and fish skin (e.g., the tensile strength [9], puncture strength [19], bending rigidity [10]), attempts to fabricate materials that mimic natural fish skins have remained limited. This thesis presents a synthetic fish skin material designed to replicate the structural, dimensional, mechanical, and functional aspects of natural teleost fish skin comprised of leptoid-like scales. The material design and fabrication has been simplified to include (i) a low modulus elastic mesh or dermis layer that holds (ii) relatively (in comparison to the mesh) rigid, plastic scales ...