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Computational Framework For Small Animal Spect Imaging: Simulation And Reconstruction, Sang Hyeb Lee
Computational Framework For Small Animal Spect Imaging: Simulation And Reconstruction, Sang Hyeb Lee
Doctoral Dissertations
Small animal Single Photon Emission Computed Tomography (SPECT) has been an invaluable asset in biomedical science since this non-invasive imaging technique allows the longitudinal studies of animal models of human diseases. However, the image degradation caused by non-stationary collimator-detector response and single photon emitting nature of SPECT makes it difficult to provide a quantitative measure of 3D radio-pharmaceutical distribution inside the patient. Moreover, this problem exacerbates when an intra-peritoneal X-ray contrast agent is injected into a mouse for low-energy radiotracers.
In this dissertation, we design and develop a complete computational framework for the entire SPECT scan procedure from the radio-pharmaceutical …