Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Allergy and Immunology (2)
- Biochemistry (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Biological Phenomena, Cell Phenomena, and Immunity (2)
- Cancer Biology (2)
-
- Cell and Developmental Biology (2)
- Disease Modeling (2)
- Diseases (2)
- Genetics (2)
- Genetics and Genomics (2)
- Immunity (2)
- Immunology and Infectious Disease (2)
- Immunoprophylaxis and Therapy (2)
- Life Sciences (2)
- Medical Immunology (2)
- Medical Specialties (2)
- Oncology (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Biomaterials (1)
- Biomedical (1)
- Biomedical Devices and Instrumentation (1)
- Computer Engineering (1)
- Electrical and Computer Engineering (1)
- Electrical and Electronics (1)
- Equipment and Supplies (1)
- Keyword
-
- Aging (2)
- Antigen (2)
- Cancer (2)
- Epitope (2)
- Immune response (2)
-
- Immunoediting (2)
- Immunosurveillance (2)
- Mutation (2)
- Transgenic mouse model of cancer (2)
- Drug delivery (1)
- Horseradish peroxidase (1)
- Hydrogel (1)
- Hydrogel ejector (1)
- Hydrogen peroxide (1)
- Live cell entrapment (1)
- Nanofiber mat (1)
- Regenerative medicine (1)
- Tissue engineering (1)
- Wound healing (1)
Articles 1 - 3 of 3
Full-Text Articles in Biological Engineering
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Honors Scholar Theses
Hydrogels are useful in wound healing, drug delivery, and tissue engineering applications, but the available methods of injecting them quickly and noninvasively are limited. The medical industry does not yet have access to an all-purpose device that can quickly synthesize hydrogels of different shapes and sizes. Many synthesis procedures that have been developed result in the formation of amorphous hydrogels. While generally useful, amorphous hydrogels exhibit limited capability in tissue engineering applications, especially due to their viscous properties. This endeavor aims to modulate the appropriate gelation parameters, optimize the injection process, and create a prototype that allows for the extrusion …
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
University Scholar Projects
Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Modeling The Adaptive Immune Response To Mutation-Generated Antigens, Rory J. Geyer
Honors Scholar Theses
Somatic mutations may drive tumorigenesis or lead to new, immunogenic epitopes (neoantigens). The immune system is thought to represses neoplastic growths through the recognition of neoantigens presented only by tumor cells. To study mutations as well as the immune response to mutation-generated antigens, we have created a conditional knockin mouse line with a gene encoding, 5’ to 3’, yellow fluorescent protein (YFP), ovalbumin (which is processed to the immunologically recognizable peptide, SIINFEKL), and cyan fluorescent protein (CFP), or, YFP-ovalbumin-CFP. A frame shift mutation has been created at the 5’ end of the ovalbumin gene, hence YFP should always be expressed, …