Biomedical Engineering and Bioengineering Commons^™

Calibration And Validation Of An In Vitro Ultrasound Device To Deliver Targeted Thermal Enhancement Of Hmsc Osteogenesis, Dionne Dawkins

Dissertations and Theses

Osteoarthritis (OA) is a disease that affects millions of people annually, often the elderly, and limits their physical abilities. Current methods of treating OA are often very invasive, and expensive, costing the Medicare system billions of dollars annually. A minimally invasive therapy that can be localized to the affected area that provides both relief and a short recovery time is optimal for treating the disease. For targeted therapy and clinical use, therapeutic ultrasound in the 0.7 MHz to 3 MHz frequency range can provide relief and is convenient, portable and localized. Low-intensity pulsed ultrasound (LIPUS) has been proven in clinical …