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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 11 of 11
Full-Text Articles in Biomedical Engineering and Bioengineering
When 1 + 1 > 2: Nanostructured Composites For Hard Tissue Engineering Applications, Vuk Uskoković
When 1 + 1 > 2: Nanostructured Composites For Hard Tissue Engineering Applications, Vuk Uskoković
Pharmacy Faculty Articles and Research
Multicomponent, synergistic and multifunctional nanostructures have taken over the spotlight in the realm of biomedical nanotechnologies. The most prospective materials for bone regeneration today are almost exclusively composites comprising two or more components that compensate for the shortcomings of each one of them alone. This is quite natural in view of the fact that all hard tissues in the human body, except perhaps the tooth enamel, are composite nanostructures. This review article highlights some of the most prospective breakthroughs made in this research direction, with the hard tissues in main focus being those comprising bone, tooth cementum, dentin and enamel. …
Cellular Events Under Flow States Pertinent To Heart Valve Function, Glenda L. Castellanos
Cellular Events Under Flow States Pertinent To Heart Valve Function, Glenda L. Castellanos
FIU Electronic Theses and Dissertations
Heart valve disease (HVD) or a damaged valve can severely compromise the heart's ability to pump efficiently. Balloon valvuloplasty is preferred on neonates with aortic valve stenosis. Even though this procedure decreases the gradient pressure across the aortic valve, restenosis is observed soon after balloon intervention. Tissue engineering heart valves (TEHV), using bone marrow stem cells (BMSCs) and biodegradable scaffolds, have been investigated as an alternative to current non-viable prosthesis. By observing the changes in hemodynamics following balloon aortic valvuloplasty, we could uncover a potential cause for rapid restenosis after balloon intervention. Subsequently, a tissue engineering treatment strategy based on …
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
The Summer Undergraduate Research Fellowship (SURF) Symposium
The field of regenerative medicine seeks to create replacement tissues and organs, both to repair deficiencies in biological function and to treat structural damage caused by injury. Scaffoldings mimicking extracellular matrix (ECM), the structure to which cells attach to form tissues, have been developed from synthetic polymers and also been prepared by decellularizing adult tissue. However, the structure of ECM undergoes significant remodeling during natural tissue repair, suggesting that ECM-replacement constructs that mirror developing tissues may promote better regeneration than those modeled on adult tissues. This work investigated the effectiveness of a method of viewing the extracellular matrix of developing …
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Electronic Theses and Dissertations
Biomaterials used for tissue engineering, specifically polymers, come from either naturally occurring, like gelatin or collagen, or synthetic sources, such as polyesters. Often times, it is advantageous to combine biomaterials in order to maximize certain material properties, such as cellular adhesion and degradation. The purpose of this study is to provide direction for the synthesis, characterization, and a combination of a combination biomaterial between fish glue (FG), a natural source polymer, and poly-lactic-co-glycolic acid (PLGA), a synthetically made polyester. First, FG is characterized for molecular weight via Gel Permeation Chromatography, GPC. Two combination methods to mix FG/PLGA solutions are then …
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Masters Theses
Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …
Piezoelectric Scaffolds For Osteochondral Defect Repair, Sita Mahalakshmi Damaraju
Piezoelectric Scaffolds For Osteochondral Defect Repair, Sita Mahalakshmi Damaraju
Dissertations
Osteoarthritis is one of the most prevalent causes of disability affecting nearly 27 million Americans. Osteoarthritis is caused when extensive damage occurs to the articular cartilage later spreading to the underlying subchondral bone, resulting in osteochondral defects. The current clinical therapies aim at regenerating the hyaline cartilage, but instead fibrocartilage forms at the osteochondral defect site, which is inferior in structure and function and fails to integrate with the surrounding tissue. A biomimetic scaffold, which can provide cues similar to the native extracellular matrix, may facilitate osteochondral defect repair. Articular cartilage and bone extracellular matrix have been shown to produce …
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Honors Scholar Theses
Hydrogels are useful in wound healing, drug delivery, and tissue engineering applications, but the available methods of injecting them quickly and noninvasively are limited. The medical industry does not yet have access to an all-purpose device that can quickly synthesize hydrogels of different shapes and sizes. Many synthesis procedures that have been developed result in the formation of amorphous hydrogels. While generally useful, amorphous hydrogels exhibit limited capability in tissue engineering applications, especially due to their viscous properties. This endeavor aims to modulate the appropriate gelation parameters, optimize the injection process, and create a prototype that allows for the extrusion …
Finite Element Analysis Of The Application Of Ultrasound-Generated Acoustic Radiation Force To Biomaterials, Nicole J. Piscopo
Finite Element Analysis Of The Application Of Ultrasound-Generated Acoustic Radiation Force To Biomaterials, Nicole J. Piscopo
Honors Scholar Theses
While most bone fractures can heal simply by being stabilized, others can take a longer time to rejoin or they could fail to merge back together completely. Numerous studies have shown the positive effects that ultrasonic therapy have had on delayed-union and non-union bone fracture repair but little is known as to what specific biological mechanisms are at play. Ultrasound may be a valuable tool for bone tissue regeneration at these fracture sites using a tissue engineering approach, however, more must be understood about its impact on stimulating tissues to heal before this can be a reality. For that reason, …
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche
3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche
Legacy Theses & Dissertations (2009 - 2024)
Among ocular pathologies, glaucoma remains the second leading cause of blindness. The molecular mechanisms that lead to glaucoma have been attributed to damage of the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm's canal, regulate and maintain homeostatic responses of aqueous humor outflow. In glaucoma, drainage of aqueous humor into the Schlemm's canal is hindered, leading to an increase in intraocular pressure (IOP). That increase in IOP is directly correlated with retinal ganglion cell death, eliminating the relay of visual information to the thalamus and visual cortex, leading to blindness. Although disturbance in …
Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser
Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser
Legacy Theses & Dissertations (2009 - 2024)
The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. However, brown adipocytes are difficult to transplant in vivo due to the instability of fat, in terms of necrosis and neovascularization, once injected. Thus, 3D cell culture systems that have the potential to mimic adipogenic microenvironments are needed, not only to advance brown fat implantation, but also to better understand the role of brown adipocytes …