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Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Bone Quality In Animal Models Of Osteoporosis, Marc Grynpas, Debbie Chachra, Kathleen Lundon
Bone Quality In Animal Models Of Osteoporosis, Marc Grynpas, Debbie Chachra, Kathleen Lundon
Debbie Chachra
The use of animal models is a very powerful tool for the preclinical assessment of potential therapies for osteoporosis. However, the effective use of animal models has two prerequisites. The first is the use of appropriate techniques to assess the overall effects of therapy on bone. As spontaneous fractures do not occur in any species other than humans, the efficacy of a therapy cannot be assessed by its impact on fracture incidence. Instead, a suite of parameters (collectively referred to as ‘bone quality’), including bone architecture, mineralization and mechanical properties, is examined. While techniques such as histomorphometry and dual-energy x-ray …
Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich
Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich
ETD Archive
No abstract provided.
Quantification Of Collagen Organization Using Fractal Dimensions And Fourier Transforms, Kayt E. Frisch, Sarah E. Duenwald-Kuehl, Hirohito Kobayashi, Connie S. Chamberlain, Roderic S. Lakes, Ray Vanderby Jr.
Quantification Of Collagen Organization Using Fractal Dimensions And Fourier Transforms, Kayt E. Frisch, Sarah E. Duenwald-Kuehl, Hirohito Kobayashi, Connie S. Chamberlain, Roderic S. Lakes, Ray Vanderby Jr.
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
Collagen fibers and fibrils that comprise tendons and ligaments are disrupted or damaged during injury. Fibrillogenesis during healing produces a matrix that is initially quite disorganized, but remodels over time to resemble, but not replicate, the original roughly parallel microstructure. Quantification of these changes is traditionally a laborious and subjective task. In this work we applied two automated techniques, fast Fourier transformation (FFT) and fractal dimension analysis (FA) to quantify the organization of collagen fibers or fibrils. Using multi-photon images of collagen fibers obtained from rat ligament we showed that for healing ligaments, FA differentiates more clearly between the different …
Alignment And Composition Of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, Edward A. Botchwey
Alignment And Composition Of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, Edward A. Botchwey
Medical Diagnostics & Translational Sciences Faculty Publications
Peripheral nerve transection occurs commonly in traumatic injury, causing deficits distal to the injury site. Conduits for repair currently on the market are hollow tubes; however, they often fail due to slow regeneration over long gaps. To facilitate increased regeneration speed and functional recovery, the ideal conduit should provide biochemically relevant signals and physical guidance cues, thus playing an active role in regeneration. To that end, laminin and lamininpolycaprolactone (PCL) blend nanofibers were fabricated to mimic peripheral nerve basement membrane. In vitro assays established 10% (wt) laminin content is sufficient to retain neurite-promoting effects of laminin. In addition, modified collector …