Biomedical Engineering and Bioengineering Commons^™

Characterizing Intervertebral Disc Strain Under Dynamic Loading Conditions Using Ultrasound Texture Analysis, Radhika Kulkarni

Discovery Undergraduate Interdisciplinary Research Internship

Herniated discs in the spine are a significant patient burden, with potential links to lower back and leg discomfort and a considerable impact on daily life. These discs, located between spinal vertebrae, are comprised of the annulus fibrosus (AF) and the nucleus pulposus (NP). Herniations happen when the NP protrudes through a full-thickness annular tear, possibly compressing spinal nerves. The mechanical factors underlying herniated discs are poorly understood, necessitating research into these mechanisms and accessible diagnostic techniques. Our study employs high-resolution ultrasound and texture correlation to quantify strain patterns in intervertebral discs during dynamic loading.

A motion segment from the …

An Automated, Deep Learning Approach To Systematically & Sequentially Derive Three-Dimensional Knee Kinematics Directly From Two-Dimensional Fluoroscopic Video, Viet Dung Nguyen

Doctoral Dissertations

Total knee arthroplasty (TKA), also known as total knee replacement, is a surgical procedure to replace damaged parts of the knee joint with artificial components. It aims to relieve pain and improve knee function. TKA can improve knee kinematics and reduce pain, but it may also cause altered joint mechanics and complications. Proper patient selection, implant design, and surgical technique are important for successful outcomes. Kinematics analysis plays a vital role in TKA by evaluating knee joint movement and mechanics. It helps assess surgery success, guides implant and technique selection, informs implant design improvements, detects problems early, and improves patient …

Effect Of Dorsal Quadrant Or Ventral Quadrant Spinal Cord Injury On Gait Features During Locomotion., Anya Nicole Trell

Electronic Theses and Dissertations

In the Unites States, approximately 1.5 million people currently have a spinal cord injury and suffer permanent sensory and motor loss due to the disruption of the spinal cord. Due to the significant morbidity, it is vital to understand the functional impact of disrupting neural descending pathways that modulate spinal neurons involved in intermuscular coordination critical for gait behaviors. Tasks that are more difficult require additional input from these neural pathways; therefore, fourteen feline subjects were familiarized with level overground locomotion and stair descent gait tasks. After collection of baseline kinematic data, the subjects received either a dorsal or ventral …

Utilization Of Finite Element Analysis Techniques For Adolescent Idiopathic Scoliosis Surgical Planning, Michael A. Polanco

Mechanical & Aerospace Engineering Theses & Dissertations

Adolescent Idiopathic Scoliosis, a three-dimensional deformity of the thoracolumbar spine, affects approximately 1-3% of patients ages 10-18. Surgical correction and treatment of the spinal column is a costly and high-risk task that is consistently complicated by factors such as patient-specific spinal deformities, curve flexibility, and surgeon experience. The following dissertation utilizes finite element analysis to develop a cost-effective, building-block approach by which surgical procedures and kinematic evaluations may be investigated. All studies conducted are based off a volumetric, thoracolumbar finite element (FE) model developed from computer-aided design (CAD) anatomy whose components are kinematically validated with in-vitro data. Spinal ligament stiffness …

Biomechanical Investigation Of Complete And Partial Medial Collateral Ligament Injuries, Callahan Doughty

Electronic Thesis and Dissertation Repository

The medial collateral ligament (MCL) is composed of two major components: the deep MCL (dMCL) and superficial MCL (sMCL). Recent indications have raised questions as to the validity of previous descriptions of the MCL’s role in knee stability. Despite the relative likelihood of partial injuries to the sMCL, as opposed to complete tears, the impact of these injuries remains largely misunderstood. This thesis set out to (1) interpret the roles of the sMCL and dMCL; and (2) investigate the effect of partial sMCL injuries on knee stability.

A joint motion simulator was used to determine the role of the dMCL …

Youth Pitching Kinematics: Associations With Body Overweight Parameters, Christina K. Fong

Master's Theses

The objective of this study was to investigate associations between injury-related kinematic parameters and overweight measures for youth baseball pitchers. The injury-related kinematic parameters considered were measurements 1) at foot contact: stride length, front foot position, shoulder external rotation, shoulder abduction, and elbow flexion; 2) between FC and ball release: peak knee extension; and 3) at BR: shoulder abduction. Data from three separate collection sites examined pitching mechanics of 18 10- to 11-year-old pitchers, 11 14- to 16-year-old pitchers, and 104 16- to 18-year-old pitchers Linear regression analyses were performed to determine significant correlations between kinematic parameters and body mass …

Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery

Electronic Thesis and Dissertation Repository

Previous studies have demonstrated that satisfaction and revision rates following total knee arthroplasty (TKA) are lower than those of comparable surgeries such as total hip replacements. A leading cause for these revisions is joint instability which may be due to improper ligament balancing or poorly aligned surgical implants. One of the methods used to investigate biomechanical forces and kinematics is computational modelling of the post-operative TKA knee.

A unique knee model was used to investigate the biomechanical and kinematic effects of ligament model complexity, as well as the effects of simulating ligament wrapping versus ignoring ligament wrapping. We then used …

The Use Of Ct To Assess Shoulder Kinematics And Measure Glenohumeral Arthrokinematics, Baraa Daher

Electronic Thesis and Dissertation Repository

Recently, studies have started employing dynamic four-dimensional computed tomography (4DCT) imaging as a biomechanical assessment tool. These studies would benefit from the valuable work that has been done in the past using three-dimensional computed tomography (3DCT). Thus, a structured review was conducted to examine the extent and range of methods employing CT imaging to measure shoulder kinematics. The findings of the review were utilized to conduct a study that employed 4DCT imaging to measure glenohumeral joint congruency and arthrokinematics during internal rotation to the back in a population of healthy individuals. The results of this work show the importance of …

4dct Analysis Of In-Vivo Carpal Kinematics During Fem, Manisha R. Mistry

Electronic Thesis and Dissertation Repository

A consensus, detailed understanding of carpal kinematics remains elusive. 4-dimensional CT (4DCT) is a validated modality capable of accurately studying in-vivokinematic motion. The objective of this work is to quantify normal, in-vivo kinematic motion of the carpus through a flexion-extension arc of motion using 4DCT. Ten healthy, un-injured volunteers underwent a 4DCT scanning protocol through a complete arc of flexion-extension motion. Kinematic changes in motion were quantified using helical axis motion data for each carpal bone. Helical axes were compared between bones and statistical analysis performed using repeated-measures ANOVA to identify difference in kinematic motion between bones (p<0.05). The carpus can be divided into four main kinematic blocks: the distal carpal block, the proximal carpal block and individual scaphoid and trapezial blocks. This work supports an additional segmentation of the trapezium from the distal carpal row, which suggests some modulation between the scaphoid and distal carpal row.

4dct To Examine Carpal Motion, Sydney M. Robinson

Electronic Thesis and Dissertation Repository

Four-dimensional computed tomography (4DCT) is a novel imaging modality initially used in cardiac imaging but recently applied to the musculoskeletal system; although its methodology has been developed, it is still in its infancy as a powerful clinical tool. Currently, scapholunate interosseous ligament (SLIL) tears, whose early symptoms are elucidated through dynamic movement, are diagnosed with static techniques that cannot visualize dynamic motion; hence, a tool is needed that is responsive and dynamic to visualize subtle abnormal carpal movements indicative of SLIL tears. It is hypothesized that 4DCT can visualize subtle dynamic carpal movements to define uninjured motion as well as …

Kinematic And Kinetic Changes After Total Hip Arthroplasty During Sit-To-Stand Transfers: Systematic Review, Junsig Wang, Safeer F. Siddicky, Michael P. Dohm, C. Lowry Barnes, Erin M. Mannen

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Background: Total hip arthroplasty (THA) is a common and effective surgical procedure that allows patients with hip osteoarthritis to restore functional ability and relieve pain. Sit-to-stand transfers are common demanding tasks during activities of daily living and are performed more than 50 times per day. The purpose of this systematic review is to obtain a comprehensive understanding of biomechanical changes during sit-to-stand transfers after THA.

Methods: Relevant articles were selected through MEDLINE, Scopus, Embase, and Web of Science. Articles were included if they met the following inclusion criteria: 1) participants underwent total hip arthroplasty without restriction on the arthroplasty design, …

In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly

Electronic Thesis and Dissertation Repository

Optimal management of the hip capsule during arthroscopic surgery has not been established. The impact of incisions made to the capsule during minimally invasive procedures on joint biomechanics, and whether repair provides any benefit, continue to be debated. The effectiveness of capsular repair to restore native kinematics may be insufficient. Therefore, a better understanding of joint behavior during various capsule conditions is needed. A new robotic system was used to analyze the effect of progressive capsulotomy incision and repairs on the behavior of a normal hip within range of motion (ROM) limits with respect to the intact joint. Complete repairs …

Accurate Measurement Of Healthy Joint Kinematics To Inform Diagnosis And Treatment, Vasiliki Kefala

Electronic Theses and Dissertations

The description of human motion has a primary importance in different scientific areas such as medicine, sports, physical therapy. Kinematics specifically studies pure motion without reference to the causes of motion such as forces. Understanding the kinematics of human movement is of critical importance in medicine and biology. Motion measure­ment can be used in order to to evaluate functional performance of limbs under normal and abnormal conditions. Kinematic knowledge is also important for diagnosis and surgi­cal treatment of joint disease and the design of implants to rehabilitate function. Accurate joint kinematics is essential to protect articular functionality. An alteration may …

Biomechanical Comparison Of The Validity Of Two Configurations Of Simulators For Body-Powered Hand Prostheses, Camille Bennett, Amanuel Matias, Brendan Smith, Jenevieve Roper, Stephen Estelle

Honors Thesis

Simulators are often used in prosthesis research to evaluate new devices or characterize aspects of prosthesis use, so as to recruit participants without amputations. Simulators, in general, must locate the prosthesis somewhere other than where the intact biological limb exists. In this study, we compared two configurations of simulators for hand prostheses to determine which leads to more natural elbow and shoulder kinematics, and in turn, which is the more valid simulator. One configuration located the prosthesis in-line with the forearm, beyond the biological hand; the other located it beside the hand. We measured the kinematics of 12 non-amputee participants …

Utilizing Neural Networks And Wearables To Quantify Hip Joint Angles And Moments During Walking And Stair Ascent, Megan V. Mccabe

ENGS 88 Honors Thesis (AB Students)

Wearable sensors were leveraged to develop two methods for computing hip joint angles and moments during walking and stair ascent that are more portable than the gold standard. The Insole-Standard (I-S) approach replaced force plates with force-measuring insoles and achieved results that match the curvature of results from similar studies. Peaks in I-S kinetic results are high due to error induced by applying the ground reaction force to the talus. The Wearable-ANN (W-A) approach combines wearables with artificial neural networks to compute the same results. Compared against the I-S, the W-A approach performs well (average rRMSE = 18%, R^{2 …}

The Development Of A Viscoelastic Ellipsoidal Model For Use In Measuring Plantar Tissue Material Properties During Walking, Jessica Lee Deberardinis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: The mechanical characteristics of the plantar tissues during walking is not well understood as most of the current research focuses on testing specific plantar regions in cadavers or while the feet of the participants are raised. In this work, it is hypothesized that a viscoelastic geometric ellipsoid model used to assess multiple structures of the foot would be accurate and robust. This model would be participant-specific and applicable to the entire stance phase of gait.

Methods: The proposed viscoelastic ellipsoid model would represent several key anatomical areas: Heel, Posterior Midfoot, Anterior Midfoot, Metatarsals 1-2, Metatarsals 3-5, Toe 1, Toe …

Kinematics During Knee Extension, Lunge, And Chair Rise, Center For Orthopaedic Biomechanics, Kevin Shelburne, Phd, Michael D. Harris, Phd, Vasiliki Kefala, Donald R. Hume, Bradley S. Davidson, A. J. Cyr, R. H. Kim, A. A. Ali, E. M. Mannen

Living Kinematics of the Knee

No abstract provided.

Effects Of Spinal Fusion For Idiopathic Scoliosis On Lower Body Kinematics During Gait, Karen M. Kruger, Christina R. Garman, Joseph J. Krzak, Adam Graf, Sahar Hassani, Sergey Tarima, Peter F. Sturm, Kim W. Hammerberg, Purnendu Gupta, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Objectives

The purpose of this study was to compare gait among patients with scoliosis undergoing posterior spinal fusion and instrumentation (PSFI) to typically developing subjects and determine if the location of the lowest instrumented vertebra impacted results.

Summary of Background Data

PSFI is the standard of care for correcting spine deformities, allowing the preservation of body equilibrium while maintaining as many mobile spinal segments as possible. The effect of surgery on joint motion distal to the spine must also be considered. Very few studies have addressed the effect of PSFI on activities such as walking and even fewer address …

Inverse Kinematic Assessment Of Rehabilitative Therapy In Children Using Orthotics, Michael P. Murphy, Jacob R. Rammer, Kaleb L. Vinohout, Meghan R. Caballero, Christy M. Cornwell, Jessica M. Fritz, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Pathologic movement patterns are characterized by abnormal kinematics that alter how muscles support the body during walking. Individual muscles are often the target of interventions with physical therapy and surgery alike, yet the tools to assess individual muscles clinically remain limited. The aim of this study is to assess OpenSim as a clinical tool for individualized rehabilitative evaluation of children using orthotics. This anatomic and kinematic modeling study was focused on pre- and post-treatment assessment of gait characteristics in fourteen children using orthotic devices. A range of four to twelve acceptable gait capture trials was collected for each child before …

Development Of An Active Finger Motion Simulator: With In-Vitro Assessments Of Tendon Loads And Joint Kinematics, Mohammad Haddara

Electronic Thesis and Dissertation Repository

Musculoskeletal injuries of the finger far outnumber those of other joints, and while in-vitro motion simulators are useful for studying joint biomechanics and evaluating surgical repairs, considerably less simulator development has been reported for the finger compared to other joints. Replication of active musculoskeletal movement during in-vitro testing has been shown to be more representative of in-vivo motion patterns, and closed-loop motion controllers are the current state-of-the-art for in-vitro kinematics studies. However, an in-vitro motion simulator with closed-loop tendon load control and simultaneous tendon excursion control has not yet been reported for the finger. This thesis outlines the design and …

The Development Of A Platform Interface With The Use Of Virtual Reality To Enhance Upper-Extremity Prosthetic Training And Rehabilitation, Ashley D. Knight

USF Tampa Graduate Theses and Dissertations

This dissertation focuses on the investigation and development of an effective prosthetic training and rehabilitation platform with the use of virtual reality to facilitate an effective process to return amputees to the highest level of independence and functioning possible.

It has been reported that approximately 10 million people live with a limb loss worldwide, with around 30% being an upper-extremity amputee. The sudden loss of a hand or arm causes the loss of fine, coordinated movements, reduced joint range of motion (ROM), proprioceptive feedback and aesthetic appearance, all which can be improved with the use of a prosthesis and proper …

Six Degrees Of Freedom: Kinematics Of The Healthy Ankle Syndesmosis Joint, Veronica A. Hogg-Cornejo

Electronic Theses and Dissertations

Syndesmotic injury, more commonly known as a "high ankle sprain", accounts for over 12% of all ankle sprain incidents in the US; of which, over 25% occur during a sporting activity. Typically, harm to the syndesmosis occurs in sports such as football, soccer, lacrosse, and hockey where it is common for an athlete to experience rapid and extreme dorsiflexion-external rotations of the foot. Severe syndesmotic sprains have been noted by clinicians as the most difficult ankle injury to accurately diagnose and treat, require the most recuperation time, and often results in life-long dysfunction. Even more problematic, 40% of patients suffering …

Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa

The Summer Undergraduate Research Fellowship (SURF) Symposium

Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known …

Functional Comparison Of Conventional Afos With The Dynamic Response Afo, Mitchell Ruble

Master's Theses (2009 -)

Ankle foot orthoses (AFOs) are commonly prescribed to provide stability and foot clearance for patients with weakened or injured musculature. The Dynamic Response AFO (DRAFO) was designed to improve proprioception at heel strike. The design includes a rigid outer shell with a cut out heel and a soft inner lining; it is typically aligned in plantarflexion and may incorporate external heel wedges. The objective of this study was to investigate the effects of the DRAFO design features and contrast its biomechanical function with that of conventional locked and articulating AFOs. The research hypotheses were: 1) DRAFO-assisted gait parameters (e.g. ankle …

Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon

Electronic Thesis and Dissertation Repository

The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.

Although this generic …

A Study Of Kinematics And Kinetics In Time-Constrained Arm Movements, Oyindamola Owoeye

Theses

Several studies such as the equilibrium point hypothesis (EPH) purport that the motor signals that descend from the brain instead of encoding muscle torques, influence an existing relationship between muscle torque and body configuration.

In the present study, the possibility of torque depending explicitly on position was tested using a task in which subjects (N=5) moved a simulated weightless frictionless mass through a small (<8 degree) elbow extension in order to move a cursor on a screen to a target location. Each subject completed 720 trials. On ~10% of trials the simulated mass was increased unknown to the subject. The relationship between the cursor’s position and the torque applied to the system was held constant even when the simulated mass was increased. Thus, any change in torque produced was neither due the subjects’ perception of the mass nor due to their perception of the cursor. The time at which the subjects torque changed direction was seen to be significantly different (p<0.005) during trials which the mass changed. This change in torque is concluded to be position-dependent. However the possibility of this being a merely mechanical effect could not be ruled out by due to poor EMG collection.

A post-hoc analysis of different position-dependent motor control models, was done. Particularly, an exponential spring model, a linear spring model, and a linear spring with relative damping model were each tested to see how well …

Biomechanical Investigation Of Elite Place-Kicking, Chase M. Pfeifer

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Many studies aim to understand the fundamentals of kicking commonly displayed by soccer players [4,6,10,16,17,18,24,25,28,29,30,34,36,38,40]. Of those studies, most are limited to a two-dimensional (2D) analysis using high-speed cameras for position tracking or utilizing electromyography to observe the activity of select muscles [4,6,18,25,29,36]. The few studies that investigate kicking using a three-dimensional (3D) model are limited in their position tracking capabilities and focus mainly on joint flexion potentials and foot speed.

This dissertation is a comprehensive biomechanical analysis (kinematic and EMG) of the field-goal place-kicking techniques of four elite kickers in American football. Data were compared and contrasted with ball …

Hockey Skating Kinematics And The Effect Of Skate Design And Technique Training, Rebecca Mae Tidman

Master's Theses (2009 -)

The purpose of this study was to investigate the effects of technique training and hockey skate design on hockey skating performance. Fourteen male subjects, aged 12-16 years, with no recent skate treadmill experience completed ten training sessions on a skating treadmill. Instruction emphasized maximizing stride width by pushing laterally with the skate pointed anteriorly. Subjects were randomly placed into one of two experimental groups based on initial skate type: traditional or Easton Mako. After completion of five sessions, skate type was switched so that skate design effects could be assessed. In contrast to a traditional hockey skate design, the Easton …

Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation, Janelle Ann Cross

Dissertations (1934 -)

The overall goal of this project was to develop and validate a biplanar fluoroscopic system and integrated software to assess hindfoot kinematics. Understanding the motion of the foot and ankle joints may lead to improved treatment methods in persons with foot and ankle pathologies. During gait analysis, skin markers are placed on the lower extremities, which are defined as four rigid-body segments with three joints representing the hip, knee and ankle. This method introduces gross assumptions on the foot and severely limits the analysis of in depth foot mechanics. Multi-segmental models have been developed, but are susceptible to skin motion …

Characterization Of Motor Adaptation And Limb Posture Regulation During Arm Reaching Movements Following Stroke, Robert Scheidt, Tina Stoeckmann

Robert Scheidt

Whether attempting to pour water into a handheld glass, or simply trying to hold a young child's hand, many activities of daily living require interaction with unpredictable or uncertain mechanical environments. Here we describe a systems identification study that used a planar manipulandum to characterize how hemiparetic stroke survivors adapt reaching movements to novel mechanical environments. By analyzing trial-by-trial variations in hand path kinematics, we found that stroke survivors are less likely than neurologically-intact subjects to adjust motor commands for upcoming movements based on hand trajectory errors experienced on previous trials. This ability is most significantly compromised in subjects with …