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Full-Text Articles in Biomedical Engineering and Bioengineering

High-Resolution/High-Contrast Mri Of Human Articular Cartilage Lesions., Shadi F. Othman, Jun Li, Osama Abdullah, Jessy J. Moinnes, Richard L. Magin, Carol Muehleman Aug 2007

High-Resolution/High-Contrast Mri Of Human Articular Cartilage Lesions., Shadi F. Othman, Jun Li, Osama Abdullah, Jessy J. Moinnes, Richard L. Magin, Carol Muehleman

School of Engineering and Computer Science Faculty Articles

BACKGROUND: Magnetic resonance microscopy (MRM) is an important experimental tool in the identification of early cartilage lesions.

METHODS: Normal and degenerated cartilage samples were imaged at 11.74 T using a standard spin echo sequence. Quantitative MR measurements for T1, T2, and ADC were obtained and mapping for T2 and ADC was performed. The bi-exponential model for T2 relaxation was also explored. Histology was carried out for comparison with MR images.

RESULTS: MR images of cartilage samples displaying early stages of degeneration were positively correlated to their histological appearance in 23-microm high-resolution images and also with much shorter imaging times ...


Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph Apr 2007

Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph

Neuroscience Faculty Publications

Reward-seeking behavior depends critically on processing of positive and negative information at various stages such as reward anticipation, outcome monitoring, and choice evaluation. Behavioral and neuropsychological evidence suggests that processing of positive (e.g., gain) and negative (e.g., loss) reward information may be dissociable and individually disrupted. However, it remains uncertain whether different stages of reward processing share certain neural circuitry in frontal and striatal areas, and whether distinct but interactive systems in these areas are recruited for positive and negative reward processing. To explore these issues, we used a monetary decision-making task to investigate the roles of frontal ...