Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Humans

Royal College of Surgeons in Ireland

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production By Osteoblasts In Vitro., Orlaith Brennan, Fergal J. O'Brien, Laoise M. Mcnamara Jan 2012

Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production By Osteoblasts In Vitro., Orlaith Brennan, Fergal J. O'Brien, Laoise M. Mcnamara

Anatomy Articles

In early postmenopausal women, estrogen withdrawal is associated with increased bone turnover leading to bone loss and increased risk of fracture. Recent studies have suggested that the remaining bone tissue is significantly stronger, stiffer and has an increased tissue-level mineral content. Such changes may occur to compensate for bone loss or as a direct result of estrogen deficiency. To date many details of the physiology of osteoblastic cells during estrogen deficiency are vague. In this study we test the hypothesis that osteoblastic matrix mineralisation is altered at the onset of estrogen deficiency. In vitro cell culture experiments were carried out ...