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Full-Text Articles in Biomedical Engineering and Bioengineering
Nonlinear Optical Microscopy Assessment Of Tissue Structure And Chondrocyte Viability Of Articular Cartilage, Michael Le
Nonlinear Optical Microscopy Assessment Of Tissue Structure And Chondrocyte Viability Of Articular Cartilage, Michael Le
All Theses
Articular cartilage functions to protect the ends of bones by providing a surface that can withstand compressive forces and minimize friction during movement. Collagen fibers form the organizational backbone of the extracellular matrix (ECM) in cartilage. Proteoglycans within the ECM function to retain water and provide the tissue with the swelling pressure needed to withstand compressional forces. Chondrocytes, the only type of cell found in articular cartilage, produces these collagen fibers and proteoglycans to maintain the tissue structure and function. Significant injuries to articular cartilage can damage the chondrocytes and disrupt their ability to maintain homeostasis in the tissue. Therefore, …
Neomycin Enhances Glutaraldehyde Crosslinking And Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Vincent Friebe
Neomycin Enhances Glutaraldehyde Crosslinking And Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Vincent Friebe
All Theses
The native heart valve will open and close an astonishing 3 billion times in the average lifetime, implicating immense biomechanical ramifications that necessitate near-flawless structure and functional behavior. Deviations from this idyllic function as a result of heart valve disease (HVD) affect millions of individuals worldwide and result in over 275,000 heart valve replacements worldwide every year. Glutaraldehyde (GLUT) cross-linked porcine aortic heart valves, a common type of bioprosthetic heart valve (BHV), are used frequently in these valve replacement surgeries. The native valve leaflets entail a tri-composite design of type I collagen, elastin and glycosaminoglycans (GAGs), each of which are …