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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Tunable Blood Shunt For Neonates With Complex Congenital Heart Defects, Ellen Garver, Christopher B. Rodell, Kristen Shema, Krianthan Govender, Samantha E. Cassel, Bryan Ferrick, Gabriella Kupsho, Ethan Kung, Kara L. Spiller, Randy Stevens, Amy L. Throckmorton
Tunable Blood Shunt For Neonates With Complex Congenital Heart Defects, Ellen Garver, Christopher B. Rodell, Kristen Shema, Krianthan Govender, Samantha E. Cassel, Bryan Ferrick, Gabriella Kupsho, Ethan Kung, Kara L. Spiller, Randy Stevens, Amy L. Throckmorton
Publications
Despite advancements in procedures and patient care, mortality rates for neonatal recipients of the Norwood procedure, a palliation for single ventricle congenital malformations, remain high due to the use of a fixed-diameter blood shunt. In this study, a new geometrically tunable blood shunt was investigated to address limitations of the current treatment paradigm (e.g., Modified Blalock-Taussig Shunt) by allowing for controlled modulation of blood flow through the shunt to accommodate physiological changes due to the patient’s growth. First, mathematical and computational cardiovascular models were established to investigate the hemodynamic requirements of growing neonatal patients with shunts and to inform design …
Scratch Damage Evolution On Metals In Total Joint Replacements, Caleb Eljach
Scratch Damage Evolution On Metals In Total Joint Replacements, Caleb Eljach
All Theses
The goal of total joint replacement (TJR) is to replace nonfunctioning joint components and relieve pain, improve quality of life, and to improve joint function. Although TJR is a successful procedure, more than 54,000 knee revisions occur each year due to factors, such as wear, loosening, infection, fracture, instability, and patient related factors (Ranawat, 2010). TJRs consist of components typically composed of polyethylene and a metallic counterface (Navarro, 2008). The sliding contact that occurs between the metal and polyethylene components has been well studied and is shown to produce both surface damage and wear of the implant components (Barbour, 1997; …
Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen
Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen
All Dissertations
Trauma diagnostics and management are major aims of research for implantable amperometric enzyme biosensor technology. Biosensors are capable of monitoring metabolic variables in a minimally invasive manner and have great potential to augment current wireless vital sign monitoring technologies in order to make a more robust physiologic status monitoring platform. The dual responsive Electrochemical Cell-on-a-Chip Microdisc Electrode Array (ECC MDEA 5037) is a recently developed electrochemical transducer for use in a wireless, implantable biosensor system for the continuous measurement of interstitial glucose and lactate. Hyperglycemia arising from insulin resistance and hyperlactatemia arising from anaerobic metabolism both occur following trauma and …
Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion
Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion
All Dissertations
It is estimated that this year more than 200,000 women in the United States will be diagnosed with breast cancer. Treatment for most occurrences of breast cancer will often include surgical removal of the tumorigenic tissue, resulting in a soft tissue defect within the subcutaneous tissue of the skin. Post-surgical reconstruction methods are often sought by patients to restore the aesthetic function of the breast via cellular or non-cellular methods; however, because of complications associated with currently used methods for breast reconstruction, researchers are investigating tissue engineering methods to produce viable autologous adipose tissue for breast reconstruction.
Previous research in …
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
All Dissertations
Despite over three decades of research in blood-material interactions, the biomaterials field has been unsuccessful in developing a truly non-thrombogenic biomaterial. This is due to an incomplete understanding of the factors underlying biomaterial-associated thrombosis, especially the mechanisms mediating the interactions of platelets with the adsorbed plasma protein layer(s) on the implant surface. The work presented here is motivated by the primary goal of delineating these mechanisms, and understanding the platelet receptors involved, as well as the domains/amino acid sequences they bind to in the protein molecules.
It is critical to differentiate between the amount and the conformation of the adsorbed …
Covalent Immobilization Of L1 Neural Cell Adhesion Molecule To Acrylated Tetronicâ® Hydrogels For Neural Regeneration, Rebecca Cribb
Covalent Immobilization Of L1 Neural Cell Adhesion Molecule To Acrylated Tetronicâ® Hydrogels For Neural Regeneration, Rebecca Cribb
All Dissertations
Spinal cord injuries cost the United States $20 billion per year, with an existing patient population of 256,000 growing by an estimated 12,000 each year. Current clinical therapies for spinal cord injury are limited to spinal immobilization and realignment via traction, surgery, administration of methylprednisolone sodium succinate (MPSS) within eight hours post-injury, and rehabilitation exercises. While these therapies are important and may minimize damage and restore limited function, there is a dire clinical need for treatments to address the growing population of chronically-injured patients.
Varying degrees of axonal regeneration and functional recovery following spinal cord injury have been achieved in …
Spatial Sensors For Quantitative Assessment Of Retrieved Arthroplasty Bearings, Melinda Harman
Spatial Sensors For Quantitative Assessment Of Retrieved Arthroplasty Bearings, Melinda Harman
All Dissertations
Evaluation of retrieved joint arthroplasty bearings provides unique evidence related to the physiological environment in which bearing materials are expected to perform. This dissertation describes the development of novel spatial sensors and measurement strategies for standardized, quantitative assessments of arthroplasty bearings, including total knee replacements, unicompartmental knee replacements, and total hip replacements. The approach is to assess bearings that endured a finite duration of function in patients, with particular emphasis on expanding our understanding of the biomechanical conditions specific to bearing function and wear in the physiological environment. Several quantifiable parameters are identified that prove comparable to pre-clinical in vitro …