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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Developing A Small-Footprint Bioengineering Program, Alisha Sarang-Sieminski, Debbie Chachra
Developing A Small-Footprint Bioengineering Program, Alisha Sarang-Sieminski, Debbie Chachra
Alisha L. Sarang-Sieminski
The field of bioengineering is rapidly changing and expanding to include not only more traditional bioengineering applications (e.g. device-focused areas such as prosthetics, imaging) but also more recent sub-fields and technologies(e.g. more biologically-focused areas such as those enabled by tissue engineering and microfluidics). This rapid change, coupled with the intrinsically interdisciplinary nature of bioengineering, presents a unique challenge to the developers of academic programs, as they need to both select relevant content and strike a balance between depth and breadth. We, the architects of the bioengineering program at the undergraduate-only Franklin W. Olin College of Engineering, which enrolled its first …
Measuring The Mechanical Properties Of Living Cells Using Atomic Force Microscopy, Nancy Burnham, Gawain Thomas, Terri Camesano, Qi Wen
Measuring The Mechanical Properties Of Living Cells Using Atomic Force Microscopy, Nancy Burnham, Gawain Thomas, Terri Camesano, Qi Wen
Nancy A. Burnham
Mechanical properties of cells and extracellular matrix (ECM) play important roles in many biological processes including stem cell differentiation, tumor formation, and wound healing. Changes in stiffness of cells and ECM are often signs of changes in cell physiology or diseases in tissues. Hence, cell stiffness is an index to evaluate the status of cell cultures. Among the multitude of methods applied to measure the stiffness of cells and tissues, micro-indentation using an Atomic Force Microscope (AFM) provides a way to reliably measure the stiffness of living cells. This method has been widely applied to characterize the micro-scale stiffness for …
Directed Cellular Self-Assembly To Fabricate Cell-Derived Tissue Rings For Biomechanical Analysis And Tissue Engineering, Kristen Billiar, Tracy Gwyther, Jason Hu, Marsha Rolle
Directed Cellular Self-Assembly To Fabricate Cell-Derived Tissue Rings For Biomechanical Analysis And Tissue Engineering, Kristen Billiar, Tracy Gwyther, Jason Hu, Marsha Rolle
Kristen L. Billiar
Each year, hundreds of thousands of patients undergo coronary artery bypass surgery in the United States.1 Approximately one third of these patients do not have suitable autologous donor vessels due to disease progression or previous harvest. The aim of vascular tissue engineering is to develop a suitable alternative source for these bypass grafts. In addition, engineered vascular tissue may prove valuable as living vascular models to study cardiovascular diseases. Several promising approaches to engineering blood vessels have been explored, with many recent studies focusing on development and analysis of cell-based methods.2-5 Herein, we present a method to rapidly self-assemble cells …