Biomedical Engineering and Bioengineering Commons^™

Pulmonary Particle Deposition In Relation To Age, Body Weight, And Species, Lisa M. Weber

Electronic Theses and Dissertations

As a result of dissimilarity in lung morphometry and physiological conditions, therapeutic aerosol particles deposit differently in humans of various ages and body weights. These particles also deposit differently in non-human species that are often utilized in inhalation and dosing studies. The focus of this work is to determine the optimal particle size and deposition (traditional efficiency and volume-weighted) of therapeutic particles in humans of both genders ranging in age from 3 months old to 21 years old and three non-human species (B6C3F₁ mouse, Long-Evans hooded rat, and Beagle dog). This study finds that in humans, both optimal …

Organization And Signal Processing Of The Descending Tracts In The Cervical Spinal Cord, Yanmei Tie

Doctoral Dissertations

This dissertation addresses the research for the development of spinal cord-computer interface (SCCI). The main objective of SCCI is to generate voluntary motor control signals for individuals with spinal cord injury (SCI).

In the neuroscience aspect, organization of the fibers in the descending tracts of the dorsolateral funiculus of the cervical spinal cord was investigated in cats. The spinal cord was penetrated with silicon substrate microelectrodes at 400 μm intervals in the medio-lateral direction at the C5/C6 and C6/C7 segmental borders. The stimulus consisted of a 20 ms train of charge-balanced biphasic pulses at 330 Hz. The evoked activities from …