Biomedical Engineering and Bioengineering Commons^™

Reversibly Switching Adhesion Of Smart Adhesives Inspired By Mussel Adhesive Chemistry, Ameya R. Narkar

Dissertations, Master's Theses and Master's Reports

Catecholic groups in mussel adhesive proteins transition from being strongly adhesive in a reduced state under acidic conditions to being weakly adhesive in an oxidized state under basic conditions. Here, we exploit this pH responsive behavior of catechol and demonstrate that its oxidation state can be manipulated by incorporation of boronic acid to facilitate reversible transitions between strong and weak adhesion. Our first approach involved the addition of 3- acrylamido phenylboronic acid (APBA) to dopamine methacrylamide (DMA) containing adhesives. The synthesized adhesives showed strong adhesion to quartz surface in an acidic medium (pH 3), while weak adhesion was observed on …

An Injectable Thermosensitive Biodegradable Hydrogel Embedded With Snap Containing Plla Microparticles For Sustained Nitric Oxide (No) Delivery For Wound Healing, Nikhil Mittal

Dissertations, Master's Theses and Master's Reports

After injury, wound healing is a complex sequential cascade of events essential for the proper recovery of the wound without the scar formation. Nitric oxide (NO) is a small, endogenous free-radical gas with antimicrobial, vasodilating and growth factor stimulating properties. NO has wide biomedical application especially in wound healing however, its usability is hindered due its administration problem as it is highly unstable.

In this work, poly (l-lactic acid) microparticles encapsulated with NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) were prepared using water-in-oil-water double emulsion solvent evaporation method for controlled delivery for NO at the specific site. The NO release from SNAP-PLLA microparticles …

A Bluetooth Low-Energy Wireless Sensor Platform For Continuous Monitoring Of A Bioreactor Environment During Cell Manufacturing, Brad Nelson

Dissertations, Master's Theses and Master's Reports

A wireless sensor platform based on Bluetooth Low-Energy (BLE) technology was designed and prototyped for continuous monitoring of physical conditions and chemical analytes, which could be applied to bioreactors during the cell manufacturing process. Controlling environmental conditions such as pH, oxygen, glucose, temperature, and pressure is vital to ensure the consistency of the manufactured cells and maintain the potency of the product. Current methods to control bioreactor conditions focus only on monitoring the cell culture environment during cell growth, but there is a lack of direct quantification of cell properties to provide an integrated feedback system that can also maintain …

Studying Mass And Mechanical Property Changes During The Degradation Of A Bioadhesive With Mass Tracking, Rheology And Magnetoelastic (Me) Sensors, Zhongtian Zhang

Dissertations, Master's Theses and Master's Reports

In this research, the degradable polymer 4-arm poly (ethylene glycol)-glutaric acid-dopamine (PEG-GA-DM₄) was synthesized. The degradation behavior of crosslinked PEG-GA-DM₄ bioadhesive was studied with mass tracking, oscillatory rheology, and magnetoelastic (ME) sensors. Changes in mechanical properties were correlated with both dry mass and wet mass changes during the degradation. The results indicate that the loss of mechanical property in the bioadhesive can take place without losing the dry mass. The mass loss profile cannot describe the degradation behavior completely. In addition to studying the degradation of PEG-GA-DM₄, this research also confirms the application of ME …