Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (116)
- Biomedical Devices and Instrumentation (86)
- Life Sciences (80)
- Electrical and Computer Engineering (60)
- Biological Engineering (56)
-
- Mechanical Engineering (52)
- Bioimaging and Biomedical Optics (51)
- Biomechanics and Biotransport (47)
- Biomaterials (43)
- Chemical Engineering (41)
- Physical Sciences and Mathematics (39)
- Molecular, Cellular, and Tissue Engineering (37)
- Medical Specialties (34)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (33)
- Other Biomedical Engineering and Bioengineering (33)
- Diseases (32)
- Biomedical (29)
- Bioelectrical and Neuroengineering (28)
- Vision Science (26)
- Medical Sciences (23)
- Other Analytical, Diagnostic and Therapeutic Techniques and Equipment (22)
- Biochemical and Biomolecular Engineering (21)
- Nanoscience and Nanotechnology (21)
- Eye Diseases (20)
- Materials Science and Engineering (20)
- Optometry (20)
- Biochemistry, Biophysics, and Structural Biology (17)
- Biology (16)
- Institution
-
- Engineering Conferences International (245)
- Marquette University (50)
- Purdue University (50)
- Virginia Commonwealth University (36)
- University of Arkansas, Fayetteville (32)
-
- Utah State University (30)
- University of Nebraska - Lincoln (28)
- University of Kentucky (27)
- Wright State University (27)
- Western University (24)
- Old Dominion University (23)
- California Polytechnic State University, San Luis Obispo (22)
- Universidad de La Salle (21)
- University of South Florida (21)
- City University of New York (CUNY) (18)
- Selected Works (17)
- New Jersey Institute of Technology (16)
- Wayne State University (13)
- Florida Institute of Technology (12)
- Missouri University of Science and Technology (12)
- Santa Clara University (12)
- University of Tennessee, Knoxville (12)
- Louisiana Tech University (10)
- Michigan Technological University (10)
- University of Louisville (10)
- University of Massachusetts Amherst (9)
- University of Denver (8)
- University of South Carolina (7)
- Clemson University (6)
- Florida International University (6)
- Keyword
-
- Applied sciences (35)
- CHO (19)
- Biomedical engineering (18)
- Biological sciences (13)
- Biomedical Sciences (11)
-
- Perfusion (11)
- CHO cells (9)
- Department of Biomedical, Industrial & Human Factors Engineering (9)
- Product quality (9)
- Biomaterials (8)
- Biomechanics (8)
- Microfluidics (8)
- Nanoparticles (8)
- Scale-down (8)
- Cancer (7)
- Daniel Felix Ritchie School of Engineering and Computer Science (7)
- Glycosylation (7)
- Health and environmental sciences (7)
- Imaging (7)
- Machine learning (7)
- Rehabilitation (7)
- Retina (7)
- Scale-up (7)
- Transcriptomics (7)
- Biomedical Engineering (6)
- Metabolism (6)
- Bioengineering (5)
- Electrospinning (5)
- Fed-batch (5)
- High-throughput (5)
- Publication
-
- Cell Culture Engineering XV (245)
- Biomedical Engineering Faculty Research and Publications (40)
- Theses and Dissertations (34)
- Doctoral Dissertations (25)
- The Summer Undergraduate Research Fellowship (SURF) Symposium (22)
-
- Browse all Theses and Dissertations (20)
- Ciencia y Tecnología para la Salud Visual y Ocular (20)
- Electronic Thesis and Dissertation Repository (20)
- Electronic Theses and Dissertations (19)
- USF Tampa Graduate Theses and Dissertations (19)
- Biomedical Engineering Undergraduate Honors Theses (18)
- Capstone Design Expo Posters (14)
- Open Access Dissertations (14)
- Master's Theses (12)
- Bioelectrics Publications (10)
- College of Engineering News (10)
- Publications and Research (10)
- Theses (10)
- UCARE Research Products (10)
- Bioengineering Senior Theses (9)
- Chemical and Biochemical Engineering Faculty Research & Creative Works (9)
- Kevin Hallinan (9)
- Wayne State University Dissertations (9)
- Masters Theses (8)
- Biological Engineering Faculty Publications (7)
- Biomedical, Industrial & Human Factors Engineering Faculty Publications (7)
- Dissertations (7)
- Graduate Theses and Dissertations (7)
- Theses and Dissertations--Biomedical Engineering (7)
- Articles (6)
- Publication Type
Articles 1 - 30 of 920
Full-Text Articles in Biomedical Engineering and Bioengineering
Shear Driven Micro-Fluidic Pump, Nihad E. Daidzic
Shear Driven Micro-Fluidic Pump, Nihad E. Daidzic
Aviation Department Publications
United States Patent, Patent Number US 9,528,503 B2, Date of Patent December 27, 2016.
An example includes an apparatus to pump a fluid. The apparatus includes a housing extending along a length defining an elongate interior, an actuator in the housing, conforming to the elongate interior, the actuator including a plurality of lumens, each having a length extending substantially parallel to the elongate interior, each from around 10 to 200 micrometers across and an actuator configured to oscillate the actuator in the actuator houslng along the length of the elongate interior with a rate differential between movement in a first …
Mannequin Challenge | Biological Engineering, Usu College Of Engineering
Mannequin Challenge | Biological Engineering, Usu College Of Engineering
College of Engineering News
Who says that learning about the various properties of Biomaterials is boring? Clearly, they haven't taken Dr. Yu Huang's BENG 2330 Properties of Biomaterials course. Not only do these students know how to distinguish the differences between natural and synthetic biomaterials.They know how to have a good time bringing the mannequin challenge into their lab clean up.
Overexpression Of Timp-3 In Chondrocytes Produces Transient Reduction In Growth Plate Length But Permanently Reduces Adult Bone Quality And Quantity, Blandine Poulet, Ke Liu, Darren A. Plumb, Phoung Vo, Mittal Shah, Katherine Ann Staines, Alexandra Sampson, Hiroyuke Nakamura, Hideaki Nagase, Alessandra Carriero, Sandra J. Shefelbine, Andrew A. Pitsillides, George Bou-Gharios
Overexpression Of Timp-3 In Chondrocytes Produces Transient Reduction In Growth Plate Length But Permanently Reduces Adult Bone Quality And Quantity, Blandine Poulet, Ke Liu, Darren A. Plumb, Phoung Vo, Mittal Shah, Katherine Ann Staines, Alexandra Sampson, Hiroyuke Nakamura, Hideaki Nagase, Alessandra Carriero, Sandra J. Shefelbine, Andrew A. Pitsillides, George Bou-Gharios
Biomedical Engineering and Sciences Faculty Publications
Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal development. As such, the control of MMP activity is vital in the complex process of bone formation and growth. We generated a transgenic mouse line to overexpress TIMP3 in mouse chondrocytes using the Col2a1-chondrocyte promoter. This overexpression in cartilage resulted in a transient shortening of growth plate in homozygote mice but bone length was restored at eight weeks …
Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
McKelvey School of Engineering Theses & Dissertations
Antibody-antigen recognition enables antibody-conjugated nanostructures to serve as plasmonic biosensors with tunable specificity. However due to the instability of antibodies, these biosensors are susceptible to changes in the environment such as heat and aridity, leading to constraints on the transportation and handling of these sensors. Here we establish a method using a metal-organic framework crystal to preserve biosensor activity under severe environmental conditions, including exposure to high temperatures, an organic solvent and a proteolytic agent. After zeolitic imidazolate framework-8 (ZIF-8) crystals formed for 12 hours on a biosensor of gold nanorods conjugated with a model antibody, rabbit IgG, 80% of …
The Quantum Biology Of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics, Robert J. Usselman, Cristina Chavarriaga, Pablo R. Castello, Maria Procopio, Thorsten Ritz, Edward A. Dratz, David John Singel, Carlos F. Martino
The Quantum Biology Of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics, Robert J. Usselman, Cristina Chavarriaga, Pablo R. Castello, Maria Procopio, Thorsten Ritz, Edward A. Dratz, David John Singel, Carlos F. Martino
Biomedical Engineering and Sciences Faculty Publications
Quantum biology is the study of quantum effects on biochemical mechanisms and biological function. We show that the biological production of reactive oxygen species (ROS) in live cells can be influenced by coherent electron spin dynamics, providing a new example of quantum biology in cellular regulation. ROS partitioning appears to be mediated during the activation of molecular oxygen (O2) by reduced flavoenzymes, forming spin-correlated radical pairs (RPs). We find that oscillating magnetic fields at Zeeman resonance alter relative yields of cellular superoxide (O2•−) and hydrogen peroxide (H2O2) ROS products, indicating coherent singlet-triplet mixing at the point of ROS formation. Furthermore, …
The Challenge Of Regulatory Excellence, Cary Coglianese
The Challenge Of Regulatory Excellence, Cary Coglianese
All Faculty Scholarship
Regulation is a high-stakes enterprise marked by tremendous challenges and relentless public pressure. Regulators are expected to protect the public from harms associated with economic activity and technological change without unduly impeding economic growth or efficiency. Regulators today also face new demands, such as adapting to rapidly changing and complex financial instruments, the emergence of the sharing economy, and the potential hazards of synthetic biology and other innovations. Faced with these challenges, regulators need a lodestar for what constitutes high-quality regulation and guidance on how to improve their organizations’ performance. In the book Achieving Regulatory Excellence, leading regulatory experts …
Finite Element Simulation And Additive Manufacturing Of Stiffness-Matched Niti Fixation Hardware For Mandibular Reconstruction Surgery, Ahmadreza Jahadakbar, Narges Shayesteh Moghaddam, Amirhesam Amerinatanzi, David Dean, Haluk E. Karaca, Mohammad Elahinia
Finite Element Simulation And Additive Manufacturing Of Stiffness-Matched Niti Fixation Hardware For Mandibular Reconstruction Surgery, Ahmadreza Jahadakbar, Narges Shayesteh Moghaddam, Amirhesam Amerinatanzi, David Dean, Haluk E. Karaca, Mohammad Elahinia
Mechanical Engineering Faculty Publications
Process parameters and post-processing heat treatment techniques have been developed to produce both shape memory and superelastic NiTi using Additive Manufacturing. By introducing engineered porosity, the stiffness of NiTi can be tuned to the level closely matching cortical bone. Using additively manufactured porous superelastic NiTi, we have proposed the use of patient-specific, stiffness-matched fixation hardware, for mandible skeletal reconstructive surgery. Currently, Ti-6Al-4V is the most commonly used material for skeletal fixation devices. Although this material offers more than sufficient strength for immobilization during the bone healing process, the high stiffness of Ti-6Al-4V implants can cause stress shielding. In this paper, …
Design Of A Modified Stewart Platform Manipulator For Misalignment Correction, Adekunle Ayoko
Design Of A Modified Stewart Platform Manipulator For Misalignment Correction, Adekunle Ayoko
Master of Technology Management Plan II Graduate Projects
This thesis work is about the design of a modified Stewart platform manipulator for misalignment correction. The common version of the Stewart platform uses six actuators. The traditional Stewart platform of this kind has a moving top plate and a fixed base plate. However, in this research, the modified design of the traditional Stewart platform is studied. It is designed to be an easy connect-disconnect platform that can wrap around different structures with different cross sections and symmetrically designed. It is able to adjust position easily by using four identical but independent linear actuators populated evenly in two parts fastened …
The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker
The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker
Electronic Thesis and Dissertation Repository
Hemiarthroplasty procedures replace the diseased side of the joint with an implant to maximize bone preservation while maintaining more native anatomy than a total joint replacement. Even though hemiarthroplasty procedures have been clinically successful, they cause progressive cartilage damage over time due to the use of relatively stiff metallic implant materials. This work investigates the role of low moduli implant material on implant-cartilage contact mechanics and early in vitro cartilage wear. A finite element simulation was developed to assess the effect of low moduli implants in the range of 0.015-0.288 GPa on contact mechanics. Higher contact area and lower peak …
Multimodal Imaging Of Photoreceptor Structure In Choroideremia, Lynn W. Sun, Ryan D. Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V. Weinberg, Kimberly E. Stepien, Gerald A. Fishman, Joseph Carroll
Multimodal Imaging Of Photoreceptor Structure In Choroideremia, Lynn W. Sun, Ryan D. Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V. Weinberg, Kimberly E. Stepien, Gerald A. Fishman, Joseph Carroll
Biomedical Engineering Faculty Research and Publications
Purpose
Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions.
Methods
Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques.
Results
Eleven CHM gene mutations (3 novel) were identified; three subjects had the same mutation and one …
The Role Of Scapular Morphology In Reverse Shoulder Arthroplasty, Ashish Gupta
The Role Of Scapular Morphology In Reverse Shoulder Arthroplasty, Ashish Gupta
Electronic Thesis and Dissertation Repository
Baseplate fixation in a reverse shoulder arthroplasty depends on adequate bone stock. In cases of severe glenoid bone loss and revision shoulder arthroplasty, deficiency of the glenoid vault compels the surgeon to attain screw fixation in the three columns of the scapula. The relationship of these columns demonstrated that the coracoid is closer to the lateral scapular pillar in females than in males. Significant gender dimorphism exists between the orientations of the three columns. The gender dimorphism is further evaluated by anthropometric measurements of the scapular body and the glenoid. The clinical significance lies in the ability to reconstruct the …
Miniature Implantable Telemetry System For Pressure-Volume Cardiac Monitoring, Kyle G. Fricke
Miniature Implantable Telemetry System For Pressure-Volume Cardiac Monitoring, Kyle G. Fricke
Electronic Thesis and Dissertation Repository
Safety Pharmacology is becoming an increasingly important field to pharmaceutical companies in order to determine if medical treatments (drugs) are safe for use in human subjects. In the pre-clinical phase, test models, most commonly small rodents, undergo various gene alterations to affect, for example, their cardiovascular system in order to emulate human diseases. Pharmaceutical companies rely on these models to determine the drug efficacy and to ensure minimal side effects and safety for human subjects. Currently, no fully implantable left-ventricle pressure--volume (PV) telemetry systems have been implemented for Safety Pharmacology assessment applications. A fully implantable PV telemetry system would not …
Quantitative Optical Studies Of Oxidative Stress In Rodent Models Of Eye And Lung Injuries, Zahra Ghanian
Quantitative Optical Studies Of Oxidative Stress In Rodent Models Of Eye And Lung Injuries, Zahra Ghanian
Theses and Dissertations
Optical imaging techniques have emerged as essential tools for reliable assessment of organ structure, biochemistry, and metabolic function. The recognition of metabolic markers for disease diagnosis has rekindled significant interest in the development of optical methods to measure the metabolism of the organ.
The objective of my research was to employ optical imaging tools and to implement signal and image processing techniques capable of quantifying cellular metabolism for the diagnosis of diseases in human organs such as eyes and lungs. To accomplish this goal, three different tools, cryoimager, fluorescent microscope, and optical coherence tomography system were utilized to study the …
Stem Cell And Tissue Engineering Research, Feng Zhao
Stem Cell And Tissue Engineering Research, Feng Zhao
TechTalks
My research focuses on stem cell and tissue engineering. By combining stem cell biology and engineering tools, the Zhao Lab seeks strategies to biofabricate completely biological tissues to regenerate or repair damaged tissues or organs. The function of engineered tissues is being strengthened by recapitulating the in vivo environment of natural tissues. The underlying mechanism is being explored through investigating the interaction of cells with environmental factors such as topographical cues, biophysical forces, and oxygen tensions. We also prompt stem cell research at Michigan Tech to meet the progress and advance of the outside scientific society. Training opportunities are consistently …
Final Design Report: Polymer Fatigue Characterization Test Method, Wyatt Ayling, Tyler Price, Brandon Stell, Michela Upson
Final Design Report: Polymer Fatigue Characterization Test Method, Wyatt Ayling, Tyler Price, Brandon Stell, Michela Upson
Mechanical Engineering
Polylogix is a team dedicated to the design, build, and testing of a fatigue machine to simulate cyclic loading on a biomedical polymer. This project is sponsored by Endologix, Inc. to provide test data characterizing mechanical material properties of various formulations of polymer used in abdominal aortic aneurysm surgeries. With this project goal, the machine must be able to test the polymer at body conditions; these include a testing temperature of 37°C and a cycling frequency ranging from 1 Hz to 10 Hz. This report proposes the following solution to this design challenge: an AC motor-driven mechanism utilizing a planetary …
An Emg-Based Patient Monitoring System Using Zynq Soc Device, Farhad Fallahlalehzari
An Emg-Based Patient Monitoring System Using Zynq Soc Device, Farhad Fallahlalehzari
UNLV Theses, Dissertations, Professional Papers, and Capstones
This thesis describes the design, development, and testing of an EMG-based patient monitoring system using the Zynq device. Zynq is a system on chip device designed by Xilinx which consists of an ARM dual cortex-A9 processor as well as an FPGA integrated into one chip. This work also analyzes the performance of image-processing algorithms on this system and compares that performance to more traditional PC-based systems. Image processing algorithms, such as Sobel edge detection, dilation and erosion, could be used in conjunction with a camera for the patient monitoring purposes. These algorithms often perform sub-optimally on processors because of their …
Radiation Therapy And Dosing Material Transport Methodology, Robert O'Brien
Radiation Therapy And Dosing Material Transport Methodology, Robert O'Brien
UNLV Theses, Dissertations, Professional Papers, and Capstones
A technique is examined here that utilizes high energy beta decays from a short lived radioisotope to treat medical conditions such as shallow cancerous lesions. A major benefit of beta particle interaction in tissue is a fixed penetration depth for the charged particle, with dose limited to the ultimate range of the beta particle. This method improves on some current techniques of radioactive brachytherapy, where "seeds" are placed inside patients through temporary or permanent implantation in order to kill cancerous cells or inhibit growth of tissue. The use of low energy gamma-rays is the most common method of treatment currently …
The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells, Allison Elaine Tomlin
The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells, Allison Elaine Tomlin
UNLV Theses, Dissertations, Professional Papers, and Capstones
Many studies have demonstrated clinical applications for the use of dental pulp stem cells (DPSC) for the treatment of various conditions. This has driven medical and scientific interest in the collection, isolation and banking of DPSC tissues for research into these potential therapies. Few studies to date have evaluated the viability of DPSC following long-term cryopreservation. The purpose of this study is to evaluate the effects of cryopreservation on dental pulp-derived stem cells (DPSC) viability over a period of three years. Dental pulp-derived stem cells were isolated and cultured from thirty-one healthy teeth. DPSC isolates were assessed for doubling-time and …
Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff
Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff
Department of Computer Science and Engineering: Dissertations, Theses, and Student Research
Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from the …
Tunneling Nanotubes: An Alternate Route For Propagation Of The Bystander Effect Following Oncolytic Viral Infection, Justin Ady, Venugopal Thayanithy, Kelly Mojica, Phillip Wong, Joshua Carson, Prassanna Rao, Yuman Fong, Emil Lou
Tunneling Nanotubes: An Alternate Route For Propagation Of The Bystander Effect Following Oncolytic Viral Infection, Justin Ady, Venugopal Thayanithy, Kelly Mojica, Phillip Wong, Joshua Carson, Prassanna Rao, Yuman Fong, Emil Lou
Biomedical Engineering and Sciences Faculty Publications
Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions which form spontaneously to connect cells at short and long-range distances. We have previously described long-range intercellular communication via TNTs connecting mesothelioma cells in vitro and demonstrated TNTs in intact tumors from patients with mesothelioma. Here, we investigate the ability of TNTs to mediate a viral thymidine kinase based bystander effect after oncolytic viral infection and administration of the nucleoside analog ganciclovir. Using confocal microscopy we assessed the ability of TNTs to propagate enhanced green fluorescent protein (eGFP), which is encoded by the herpes simplex virus NV1066, from infected to uninfected …
Device Design Factors For Enhancing The Functionality Of Chronic Intracortical Microelectrodes, Heui Chang Lee
Device Design Factors For Enhancing The Functionality Of Chronic Intracortical Microelectrodes, Heui Chang Lee
Open Access Dissertations
Intracortical microelectrodes are devices used in brain-computer interfaces (BCI) to help regain lost motor, sensory, and cognitive functions of individuals with neurological disorders. However, the long-term performance of microelectrode arrays is hampered by a series of inflammatory tissue responses. The consequence of the inflammatory response is the formation of a dense astroglial sheath around the vicinity of the electrode, impeding the electrical conduction between the electrode and neurons. Furthermore, due to the cascade of neuroinflammatory events, the number of neurons is significantly reduced near the electrode, manifested by decrease in signal-to-noise ratio (SNR) and the yield of electrodes. Over time, …
Characterizing The Effects Of Repetitive Head Trauma In Female Soccer Athletes For Prevention Of Mild Traumatic Brain Injury, Diana Otero Svaldi
Characterizing The Effects Of Repetitive Head Trauma In Female Soccer Athletes For Prevention Of Mild Traumatic Brain Injury, Diana Otero Svaldi
Open Access Dissertations
As participation in women’s soccer continues to grow and the longevity of female athletes’ careers continues to increase, prevention of mTBI in women’s soccer has become a major concern for female athletes as the long-term risks associated with a history of mTBI are well documented. Among women’s sports, soccer exhibits the highest concussion rates, on par with those of men’s football at the collegiate level. Head impact monitoring technology has revealed that “concussive hits” occurring directly before symptomatic injury are not predictive of mTBI, suggesting that the cumulative effect of repetitive head impacts experienced by collision sport athletes should be …
Dynamic Holography In Semiconductors And Biomedical Optics, Hao Sun
Dynamic Holography In Semiconductors And Biomedical Optics, Hao Sun
Open Access Dissertations
Three-dimensional scanning and display are rapidly-advancing new technologies with important commercial drivers such as 3D printing and remote imaging for big data applications. Holography is a natural approach to recording and displaying three-dimensional information because it uses phase-sensitive interferometry to record interference patterns when a reference beam encounters coherent light arriving from an object. The 3D information is contained in the values of wave optics. Holography is a broad field that goes beyond recording and displaying. For instance, holographic optical elements, which take advantage of holographic imaging principles, perform the functions of lenses, gratings or mirrors. Holographic interferometry is also …
Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo
Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo
Open Access Theses
Bone morphogenetic proteins (BMPs) drive a range of cellular processes especially in the early stages of embryonic development. This family of proteins acts as one of the most important extracellular signals in development pattern formation across the animal kingdom. Cells in embryos differentiate into different cell types in response to the concentration level of BMP. This complex process is regulated by multiple regulators that serve to tune the signal response.
Extensive experimental and computational research has been performed to analyze BMP regulation in Drosophila, a widely studied model organism, and has advanced our understanding of animal development. Because of …
Concurrent Detection And Isolation Of Cellular And Molecular Biomarkers, Wanfeng Huang
Concurrent Detection And Isolation Of Cellular And Molecular Biomarkers, Wanfeng Huang
Open Access Dissertations
Detection of cancer markers such as protein biomolecules and cancer cells in bodily fluids is of great importance in early diagnosis, prognosis as well as evaluation of therapy efficacy. Numerous devices have been developed for detecting either cellular or molecular targets, however there has not yet been a system that can simultaneously detect both cellular and molecular targets effectively. Molecule and cell-based assays are important because each type of target can tell a different story about the state of the disease and the two types of information can potentially be combined and/or compared for more accurate biological or clinical assessments. …
Laser-Processed Parchment Paper For Fabrication Of Chronic Wound Dressings With Selective Oxygenation, Manuel Ochoa
Laser-Processed Parchment Paper For Fabrication Of Chronic Wound Dressings With Selective Oxygenation, Manuel Ochoa
Open Access Dissertations
Chronic non-healing wounds (e.g., diabetic foot ulcers and bed sores) impact over 6.5 million Americans per year, costs in excess of $25 billion to treat on an annual basis, and are on the rise due to increasing levels of obesity and diabetes compounded by an aging population. A major inhibitor of healing is suboptimal oxygenation of the wound bed. Unlike acute injuries that receive sufficient oxygen via a functional blood vessel network, chronic wounds often suffer from the lack of a proper vascular network; thus being incapable of providing sufficient oxygen for tissue growth. Typical medical treatment of hypoxic chronic …
Knee Joint Internal Forces During Squat Jump Exercise, Ricardo Moreno
Knee Joint Internal Forces During Squat Jump Exercise, Ricardo Moreno
Theses and Dissertations
The purpose of this research is to investigate muscular ligament and joint contact forces produced during squat jump exercise. An inverse dynamics, two dimensional, leg model is used to describe the motion in the sagittal plane. The lower extremity model includes two bones, tibia and femur, tibio-femoral ligaments, and muscles such as quadriceps, hamstrings, and gastrocnemius. The ligaments are anatomically modeled as nonlinear strings, but the femoral condyle is modeled as a circle and the tibial plateau as a straight line. Experimental squat jump exercises are conducted to obtain the ground reaction forces, the angular accelerations, and centroid linear acceleration …
Nanoindentation Techniques For The Evaluation Of Silicon Nitride Thin Films, Weston T. Mangin
Nanoindentation Techniques For The Evaluation Of Silicon Nitride Thin Films, Weston T. Mangin
Master's Theses
Silicon nitride thin films are of interest in the biomedical engineering field due to their biocompatibility and favorable tribological properties. Evaluation and understanding of the properties of these films under diverse loading and failure conditions is a necessary prerequisite to their use in biomedical devices. Three wafers of silicon nitride-coated silicon were obtained from Lawrence Livermore National Laboratory and used to create 96 samples. Samples were subjected to nanoindentation testing to evaluate the mechanical properties of the film. Samples were subjected to nanoimpact testing to compare the damage resistance of the film to separate nanoimpact types. Samples were subjected to …
Functional 3-D Cellulose And Nitrocellulose Paper-Based, Microfluidic Device Utilizing Elisa Technology For The Detection/Distinction Between Hemorrhagic And Ischemic Strokes, Alicia Leanne Holler
Functional 3-D Cellulose And Nitrocellulose Paper-Based, Microfluidic Device Utilizing Elisa Technology For The Detection/Distinction Between Hemorrhagic And Ischemic Strokes, Alicia Leanne Holler
Master's Theses
The purpose of this thesis project is to demonstrate and evaluate an enzyme-linked immunosorbent assay (ELISA) on a paper microfluidic device platform. The integration of ELISA technology onto paper microfluidic chips allows for a quantitative detection of stroke biomarkers, such as glial fibrillary acidic protein (GFAP). Dye experiments were performed to confirm fluid connectivity throughout the 3D chips. Several chip and housing designs were fabricated to determine an optimal design for the microfluidic device. Once this design was finalized, development time testing was performed. The results confirmed that the paper microfluidic device could successfully route fluid throughout its channels at …
Hollow Fiber Membranes For Artificial Lung Applications, Lauren Reed
Hollow Fiber Membranes For Artificial Lung Applications, Lauren Reed
Chemical Engineering Undergraduate Honors Theses
Artificial lungs are in use, but difficult issues remain in the field of membrane development related to fouling issues. Currently there are external artificial lungs circulating blood outside the body, taking out the carbon dioxide, and inserting oxygenated blood back into the body. An example of this type of machine is the ExtraCorporeal Membrane Oxygenation (ECMO) machine currently used in hospitals. The ECMO takes over the functions for both the lungs and the heart but is only available for short term use by patients with respiratory failure due to infections [1]. The fibers in the machine develop fouling due to …