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Full-Text Articles in Biomedical Engineering and Bioengineering
The Effect Of Various Pathologies On Bone Quality, Daniel S. Porter
The Effect Of Various Pathologies On Bone Quality, Daniel S. Porter
Theses and Dissertations--Biomedical Engineering
Bone’s ability to resist fracture is often ignored until a low-energy fracture occurs. Patients with Chronic Kidney Disease (CKD) or osteoporosis are at an increased risk of low-energy fracture. Generally, fracture risk is evaluated by using a bone mineral density (BMD) test. BMD values; however, do not fully predict bone’s ability to resist fracture. This suggests that other parameters may be involved. Bone quality is the term used to describe these parameters, which are categorized into three groups: structural, material, and microdamage. The aim of this dissertation research was to examine whether bone quality was altered in patients who: 1) …
Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward
Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward
Theses and Dissertations--Biomedical Engineering
Oral bisphosphonate drug therapy is a common and effective treatment for osteoporosis. Little is known about the long-term effects of bisphosphonates on bone quality. This study examined the structural and mechanical properties of trabecular bone following 0-16 years of bisphosphonate treatment. Fifty-three iliac crest bone samples of Caucasian women diagnosed with low turnover osteoporosis were identified from the Kentucky Bone Registry. Forty-five were treated with oral bisphosphonates for 1 to 16 years while eight were treatment naive. A section of trabecular bone was chosen from a micro-computed tomography (Scanco µCT 40) scan of each sample for a uniaxial linearly elastic …